作用于血管的

The resultsdemonstrate:(1) GABA causes a decrease of blood pressure and heart rate by inhibiting sympathetic nerve in the part of the diencephalon, mesencephalon and medulla.

氨基丁酸在心血管活动中起着重要的调节作用。实验结果表明：(1)GABA可以作用于部分间脑、中脑和延髓而抑制交感神经，产生降低血压，减慢心率的作用。

VEGF and its receptor are highly expressed in most malignant tumors, through para/autoendocrine reaction, promoted endothelial cell division, proliferation and induced vascular neogenesis, directly affecting tumor cell and provoking it to grow.

在绝大多数恶性肿瘤中均呈现VEGF及其受体的高表达，以旁／自分泌作用机制，促进内皮细胞分裂、增殖、诱导血管新生，并可直接作用于肿瘤细胞，刺激肿瘤细胞生长。

The promise of these drugs is also connected to the fact that we have begun to understand that rennin may have effects independently on the formation of angiotensin II to the traditional pathways.

之所以说这种新药很有前景还有一部分原因是，我们已经开始懂得肾素对血管紧张素II的形成有一定的作用，且这种作用不依赖于传统的作用途径。

The promise of these drugs is also connected to the fact that we hae begun to understand that rennin may hae effects independently on the formation of angiotensin II to the traditional pathways.

之所以说这种新药很有前景还有一部分原因是，我们已经开始懂得肾素对血管紧张素II的形成有一定的作用，且这种作用不依赖于传统的作用途径。

The pressor effect of adenosine was due to carotid body cheoreceptor activation. However, a slight increase of ABP induced by intracarotid bolus injection of adenosine following the section of carotid sinus nerves was observed in a few rats, which implied that the central effect might be involved in the pressor effect of adenosine. The delayed effect of adenosine may be attributed to the direct actions (including the negative chronotropic action, thenegative dromotropic action, the negative inotropic action and the vasodilator effect) of adenosine on the heart and blood vessels.

前一效应主要与颈动脉体化学感受器的激活有关，但在少数动物，颈动脉内注射腺苷的升压效应在切除窦神经后并未完全消除，表明腺苷有可能进入神经中枢而发挥作用；后一效应可能由腺苷直接作用于心脏和血管，通过其负性变力、变时、变传导和血管扩张等作用，导致心脏自律性降低，输出量减少和外周阻力下降。

Elastic fibers were well-distributed,and vascular endothelial cell did not immigrate.We suggested that expression of ectogenic VEGF triggered paracrine and autocrine of VEGF of chondrocyte and co-acted with VEGF receptor 2 to enhance permeability of chondrocyte and improve internal construct of engineering cartilage,and prevent vascularize proceed.

转VEGF基因软骨细胞作为组织工程的种子细胞与pluronic F-127复合后可于裸鼠体内形成转基因组织工程软骨，与对照组相比，转VEGF基因组织工程软骨具良好的生物学特性，结构均一且与正常软骨组织相似，软骨ECM的GAG、COLⅡ、COLⅩ增多，RunX2、Sox9表达增高，细胞处于增生期的肥大状态，初步分析其原因可能是转染后外源性的VEGF持续表达触发了软骨细胞VEGF自分泌，并通过VEGFR-2作用于软骨细胞，提高了软骨细胞活性，促进其存活与增殖，但未在软骨组织内引起血管内皮细胞的迁移及小血管形成。

Maximum tolerable dose and lowdose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells ［J］.

在肿瘤的新生血管形成过程中，内皮细胞起决定性的作用，这些内皮细胞一部分直接来自肿瘤组织内原有血管的内皮细胞的芽生生长，一部分来自于骨髓内的内皮祖细胞的动员和释放［2］。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Cardiac hypertrophy and extracellular matrix remodeling happened as a result of chronic overrange of pressure in heart and hypervolaemia which lead to damage of relaxation and compliance of heart.Drugs including renin-angiotensin converting enzyme inhibitor,angiotensin receptor blocker,aderergic receptor blocker,aldrosteron antagonism,tatins endothelin receptor blocker pancreatic kiniogenase and calcalium channel blocker,can delay or reverse the remodeling by several mechanisms.

主要表现为心脏在慢性超负荷的压力、容量作用下发生的病理改变致使左室肥厚组织胶原结构发生改变，导致心肌顺应性降低，舒张功能受到损害；作用于肾素-血管紧张素系统的药物及肾上腺素受体阻滞剂、醛固酮拮抗剂、他汀类药物、内皮素受体拮抗剂、胰激肽原酶、钙通道阻滞剂等药物通过不同途径和机制延缓和逆转左心室重构。

Objectives In order to investigate how does King's Brain pill work or mechanism of King's Brain pill effective in treating AD clinically, we observed effects of extract of King's Brain on neuronal and vascular lesions induced by Aβ combining with praxiology and neuropathology.

目的 运用现代分子神经病理学和行为学技术，围绕炎症假说、淀粉样蛋白瀑布流假说，以神经元和脑血管为保护目标，着眼于AD的关键病理机制Aβ（β淀粉样蛋白沉积和淀粉样血管病变）及其代谢，开展中药补肾活血化痰复方制剂金思维对损伤的神经元和血管的保护作用机理研究，从而探讨其防治老年性痴呆的机理。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失