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RESULTS:After pinealectomized mice was irradiated WBI with 75 mGy X-rays,we found levels of plasma corticosterone increased obviously,and the effects of the proliferative reaction of splenocytes to ConA and spontaneous proliferation of thymocytes was found to be decrease. But injecting melatonin into pinealectomized mice or putting melatonin in the cultured cell,its immune functions might renew the enhancement.CONCLUSION:Melatonin of pineal gland might regulate the immunoenhancement induced by low dose radiation.MeSH Pineal body; Melatonin; Radiation; Corticosterone; Immunity,cellular

低剂量辐射(low dose radiation,LDR)全身照射(whole body irradiation,WBI)可引起免疫系统的兴奋效应,主要表现在以T淋巴细胞功能激活为主的细胞免疫和体液免疫功能的增强并可提高机体的抗瘤作用[4,5],在LDR诱发免疫功能增强的同时伴有下丘脑-垂体-肾上腺皮质系统功能下调等神经内分泌功能的改变,神经内分泌对免疫系统的调节可能是LDR免疫兴奋效应发生的必要条件,松果腺MLT与辐射免疫兴奋效应的关系值得研究。

Plutella xylostella larvae of a strain highly resistant to spinosad were used as hosts to rear the parasitoid Cotesia plutellae. When the parasitoids had developed to the stage of early instar larva, the host larvae were treated with 50 mg/L spinosad on the terga by topical application and then fed with cabbage leaves treated with 50 mg/L spinosad to allow the host larvae and the parasitoid larvae to develop. Three days after treatment, the parasitoid larvae inside the host were collected by dissecting the host larvae. The body fluid of P. xylostella and the bodies of parasitoid larvae were then analyzed with HPLC. Both of the active components, spinosyn A and spinosyn D, of spinosad were detected in the body fluid of host larvae and in the bodies of parasitoid larvae, and the residue concentrations were 2.79 mg/L and 0.94 mg/L in the host and the parasitoid respectively.

以对多杀菌素高抗的小菜蛾Plutella xylostella幼虫作为菜蛾绒茧蜂Cotesia plutellae的寄主,待绒茧蜂发育到1龄幼虫时,将浓度为50 mg/L的多杀菌素点滴到寄主幼虫背板上,随后让寄主幼虫取食经50 mg/L多杀菌素处理过的甘蓝叶片,寄主幼虫和其体内的蜂幼虫再发育3天后,将寄主幼虫解剖取出蜂幼虫,用高效液相色谱法对经多杀菌素处理的小菜蛾幼虫体液以及绒茧蜂幼虫匀浆液进行检测,结果多杀菌素的2个活性成分spinosyn A和spinosyn D均被检测到,两者的多杀菌素残留浓度分别是2.79 mg/L和0.94 mg/L。

Compared with control,①the mean tumor weight of H22 of SXKA Granules three dose groups were decreased significantly(P.01,P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 30%;②the mean tumor weight of S180 of SXKA Granules three dose groups were decreased significantly(P.01),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;③the mean tumor weight of EAC of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20 g/kg dose groups were above 38%;④the mean tumor weight of Lewis carcinoma of SXKA Granules three dose groups were decreased significantly(P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10、5 g/kg dose groups were above 36%;⑤the mean tumor weight of W256 of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;⑵Compared with control,SXKA Granules 20、10 g/kg dose groups had extended the survial time of the P388-bearing mice respectively(P.01),and the mean prolong rates of SXKA Granules 20、10 g/kg dose groups were above 50%;⑶Compared with S180-bearing group, SXKA Granules 20、10 g/kg dose groups could increase the weight of thymus and spleen, Spleen index and thymus index were increased, SXKA Granules 5 g/kg dose group could increase thymus index(P.05);⑷As Compared with control group, SXKA Granules 20、10 g/kg dose groups could improve mouse serum half hemolysis value depressed by transplanted tumor dramatically(P.01), which revealed the SXKA granules could improve the mouse humoral immunity system;⑸SXKA Granules 20 g/kg dose group could increase of englobe indexαon S180-bearing mice remarkably(P.01), which indicated the SXKA Granules could improve their cellular immunity system.

对荷W256大鼠,生兴克癌冲剂20、10、5 g / kg三组的平均瘤重明显低于对照组(P.01,P.05),生兴克癌冲剂20、10 g / kg组的平均肿瘤抑制率均大于32 %;⑵与空白对照组相比,生兴克癌冲剂20、10 g/ kg能显著地延长移植小鼠白血病P388小鼠的存活天数(P.01),生兴克癌冲剂20、10 g/ kg对荷白血病P388小鼠生命延长率均在50%以上;⑶与S180荷瘤组相比,生兴克癌冲剂对荷瘤鼠的免疫器官重量、胸腺指数和脾指数有一定的提高趋势,其中生兴克癌冲剂5 g / kg组对荷瘤小鼠的胸腺指数有一定的提高作用(P.05);⑷与S180荷瘤组相比,生兴克癌冲剂20、10 g /kg组可提高由荷瘤引起的小鼠血清半数溶血素值的降低(P.01),表明其可提高荷瘤小鼠体液免疫功能;⑸与对照组相比,生兴克癌冲剂20 g /kg组可提高荷S180肉瘤小鼠的免疫吞噬系数α值(P.01),表明其可提高荷瘤小鼠细胞免疫功能。

Thus our study indicates that impaired immunity against nontyphoidal Salmonella bacteremia in HIV infection results from excess inhibitory antibodies against Salmonella LPS whereas serum killing of Salmonella is induced by antibodies against outer membrane proteins.

他们的发现意味着HIV所造成的缺陷不止是细胞介导的免疫,而体液免疫(是由分泌的抗体所介导的)在以LPS蛋白为标靶的免疫反应中也受到了相当大的损害。

Though the primary stimulator of 1H is not clear, it is related to physical, cell and body fluid IH is a chronic process involving multiple faction injury and blood flowing abnormal are revamped as the main reason, the proliferation level depend on the length and width of the injure of vessel large amount research illustrate injury cause many growth factor infolded in IH, for example: template derived growth factor, fibroblast growth factor, transmission growth factor , endothelin (ET-1) et al, some early responsive gene such as c-fos、c-jun c-myc also take part in SMC proliferation after vessel injury.

虽然IH的确切起始刺激因子并未阐明,但已知与物理、细胞和体液因子有关。IH是一个多因素参与的慢性过程,损伤和血液动力学异常一真被认为是IH的主要因素。内膜增殖的程度有赖于血管损伤的长度和深度。近年来大量的实验研究结果表明,损伤等刺激引起的众多的生长因子样物质在IH中起关键作用。如血小板源性生长因子、碱性纤维母细胞生长因子、转化生长因子β、内皮素-1(ET-1)等诸如C-fos、C-jun、C-myc等早期应答基因也参与了血管损伤后SMC的增殖。

I can feel the blackness of every male taking root within my body, palpitating my soul.

如果有人问我,我会说,当晚上一个人独处房间,当把灯光熄灭,点起菸,你可以听见一些些微弱的声音,那像男人的喘息,像呻吟,像翻身床垫发出的声音,而你的毛孔将会放大,你可以感觉的到那黑色的雨从身体里流出,在每一个汗毛之间流动,从每一个毛细孔里流了出来,那是他的柑橘调香水,那是他汗湿的背心,那是他黏滑的体液,我可以感觉到每个男人的黑,在我体内扎根,在我灵魂里磨擦,当你发现自己再也不是一片白水而是阵黑雨,你会发现自己的生命像颗地球,在黑雨的沾染中温室化,在整片的火海中失去温度,你只能尖叫,发现自己的身体早已不是自己,被别人的回忆与习性占满而崩毁,世界只剩满满的无法忘怀与不能割舍,只剩下找寻另一个相似物另一个填充另一片黑雨,没有人逃的过这场浩劫,上帝终要人们复杂的互相侵蚀,在最后消灭回归。

I can feel the blackness of every male taking root within my body, palpitating my soul.

妳怕黑吗?』如果有人问我,我会说,当晚上一个人独处房间,当把灯光熄灭,点起菸,你可以听见一些些微弱的声音,那像男人的喘息,像呻吟,像翻身床垫发出的声音,而你的毛孔将会放大,你可以感觉的到那黑色的雨从身体里流出,在每一个汗毛之间流动,从每一个毛细孔里流了出来,那是他的柑橘调香水,那是他汗湿的背心,那是他黏滑的体液,我可以感觉到每个男人的黑,在我体内扎根,在我灵魂里磨擦,当你发现自己再也不是一片白水而是阵黑雨,你会发现自己的生命像颗地球,在黑雨的沾染中温室化,在整片的火海中失去温度,你只能尖叫,发现自己的身体早已不是自己,被别人的回忆与习性占满而崩毁,世界只剩满满的无法忘怀与不能割舍,只剩下找寻另一个相似物另一个填充另一片黑雨,没有人逃的过这场浩劫,上帝终要人们复杂的互相侵蚀,在最后消灭回归。

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With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务,乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐,因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。

Closes the eye, the deep breathing, all no longer are the dreams as if......

关闭眼睛,深呼吸,一切不再是梦想,犹如。。。。。。