体大

Results:(1) Progesterone-treated models showed intact nasal mucosa, regular ciliary lining and inactive glands;(2) Untreated or normal saline treated models showed disrupted mucosa, inverted cilia and massive mucosal infiltration of neutrophils;(3) Smearing of nasal discharge revealed limited vs abundant number of neutrophils in SD models treated with progesterone vs untreated or treated with normal saline.(4) Hoechst stain: significantly fewer apoptotic cells per field were found in progesterone-treated models (1.583 ± 0.28) compared with untreated or normal saline treated models (2.85 ± 0.285 and 4.8 ± 0.715, respectively).

结果：(1)用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮完整，纤毛整齐，腺体开放不多；(2)用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔黏膜上皮纤毛倒伏，上皮结构散乱，上皮层大量中性粒细胞浸润；(3)鼻腔分泌物涂片示黄体酮滴鼻液治疗的SD大鼠有少许中性粒细胞，而用或不用生理盐水滴鼻液治疗的SD大鼠鼻腔分泌物含有大量中性粒细胞；(4)Hoechst染色：用黄体酮滴鼻液治疗的SD大鼠鼻腔黏膜上皮凋亡细胞数［(1.583±0.28)/视野］明显少于用或不用生理盐水滴鼻液治疗的SD大鼠［分别是(2.85±0.285)/视野和(4.8±0.715)/视野］。

In Late Jurassic period (159-135Ma), when the orientation of maximum principal compressive stress was NW direction, the Wuzhangshan granite intruded to upward, accompanied the formation of NW trending Sanrenchang and Huangshuian breccia pipe belts; In the Early Cretaceous period (135-120Ma), when the orientation of maximum principal compressive stress was NNW trending, the second stage of Huashan granite intruded to upward, accompanied the formation of NW trending Qiyugou breccia pipe belts; In 120-105 Ma, when the orientation of maximum principal compressive stress changed to NE direction, the gold-bearing quartz veins and gold orebodies in breccia pipes were formed along the NE trending fractures; In the Middle Cretaceous period (105-85 Ma), when the orientation of maximum principal compressive stress was NEE, the NEE trending Leimengou granite porphyry intruded to upward, accompanied the formation of NEE trending Leimengou breccia pipe belts.

在晚侏罗世(159～135Ma)，构造应力场最大压应力方向为NW向，形成了NW走向的五丈山岩体以及NW向展布三人场、黄水庵两个角砾岩带；在白垩纪早期(135～120Ma)，最大压应力为NNW向，形成了花山岩体第二期上侵，并伴有NW向的祁雨沟角砾岩带；其后(120～100Ma)，构造应力场最大压应力方向变为NE向，形成了NE向含金石英脉及角砾岩体中金矿体；最后(100～80Ma)，形成了雷门沟花岗斑岩以及NEE向展布的雷门沟-杨河沟角砾岩带(区域构造应力场的最大主压应力方向为NEE向)。

Type B is found in chlorophyta, high plant chloroplasts and cyanobacteria with two exceptions, Prochlorococcus marinus and Synechococcus sp.

RubisCO可分为三种类型：Ⅰ型存在于植物和一些光合细菌中，是由8个大亚基和8个小亚基形成的16聚体L_8S_8；Ⅱ型存在于甲藻和某些光合细菌中，通常由大亚基形成2聚体L_2；而Ⅲ型存在于一些古细菌中，先由2个大亚基形成2聚体L_2，再由5个2聚体形成10聚体(L_2)_5。

Based on investigating the short and intermittent structural plane, surrounding rockmass of the huge underground powerhouse in Three Gorge has been divided into five statistical similar areas according to its characteristic of rockmass structure by applying structure plane network simulation. Distributed characteristic of structural plane has been studied and based on it mechanics macrocharacteristic has been studied:(1) It is the first time that based on the result of structural plane network simulation rockmass quality of every structure area has been studied with applying blurred information optimum seeking technique and be compared with and RQD method. The result indicated that it has better effect to evaluate rock quality with blurred information optimum seeking technique.(2) It is the first time that the interrelated relationship of the result of in-suit rockmass deformation test and fractal characteristic of structure on test point has been applied to determine rockmass deformation parameter. The question of evaluating deformation parameters of engineering rockmass has been solved.(3) Anisotropy strength parameters have been determined by applying shear zones simulating method. The result indicated that there are different strength parameters in every structural area, after comparing the result of Fast Lagranian Analysis in continua number simulation method with that of method of weighted mean according to continuity. The result indicated that when a suitable reduction coefficient is been considered rockmass strength parameters can be simply and fast determined with method of weighted mean according to continuity where there is not enough test result.(4) Damage characteristic has been studied based on analysis fractal characteristic of structural plane network by applying fractal-damage coupling method. It is the first time that the concept of damage degree has been set up to evaluate rockmass quality according to the biggest principal damage.

通过对短小、断续性结构面统计特征的研究，将地下厂房区划分为五个岩体结构统计均质区，应用结构面网络模拟技术研究了各个岩体结构均质区结构面的发育分布特征，并以此为基础对岩体宏观力学特性进行了深入研究：(1)首次通过在结构面网络模拟计算结果的基础上，应用模糊信息优化技术研究了厂房区各个岩体结构分区的岩体质量并与岩体基本质量指标研究法、岩体质量指标RQD值研究法作了对比，结果表明以结构面网络模拟结果为基础，应用模糊信息优化技术进行岩体质量评价能够取得很好的效果，解决了工程岩体质量的定量评价问题；(2)首次通过对已有的现场大型岩体变形试验结果的分析及相应试验点岩体结构分形特征的研究，建立了结构面分布的分形维数和岩体变形指标间的相关关系，并首次应用这种相关关系根据结构面网络模拟及分形维数计算结果确定了缺少试验结果的地下厂房各工程部位的岩体变形指标而且应用于围岩稳定性计算，解决了工程岩体宏观变形参数的评价问题；(3)应用在结构面模拟网络图上模拟岩体剪切破坏带的方法，得出了岩体在不同方向上的强度参数，结果表明岩体的强度特性与结构面的发育方向和程度有着明显的关系，各个岩体结构均质区具有不同的强度参数；同时还通过应用拉格朗日差分法对岩体强度指标的数值分析并与按连通率加权平均计算法对比表明，按连通率加权平均计算法在考虑合理的折减系数情况下，可以简单快速地对缺少现场大型试验结果的具体工程部位实现岩体强度指标的估计，通过以上研究解决了工程岩体抗剪强度参数的评价问题；(4)通过结构面网络分形维数的研究，应用分形损伤耦合分析方法，研究了厂房区岩体的损伤特征，并首次引入"损伤度"的概念，建立了应用最大主损伤评价岩体质量的指标体系。

Results show that floes' VC and D at the surface water were closely related to current velocity; and the peaks of VC lag those of the current velocity. The lag variation during ebb and flood tides is 10-30min and 30-50 min, respectively. Current velocity at 50 cm/s is a turning point of D vs. vertical average current velocity, before the point, Dm increases with current velocity, and decreases after the point. Similarly, VC at 75μl/L becomes a critical point in the surface water, below the point, D increases with VC, and above the point, D stabilizes.Δp is D dependent, larger floes have much lower Δp than smaller floes. Both D and Δp of floes affect ω. In the surface water during spring tide and neap tide, a power exponent relationship exists between Δp and D, and ω and D.

研究表明：①长江口徐六泾表层絮凝体体积浓度主要受水流流速影响，再悬浮现象明显，体积浓度过程线滞后流速过程线，落潮期间滞后10-30min，涨潮则滞后30-50min；②小于一定流速时絮凝体平均粒径随流速增大而增大，大于一定流速时絮凝体平均粒径则随流速增大而减小，徐六泾夫、小潮表层絮凝体在50cm/s的垂线平均流速时出现平均粒径与垂线平均流速关系的转折；③徐六注大、小潮表层絮凝体平均粒径在体积浓度75μl/L时出现平均粒径与体积浓度关系的转折，体积浓度小于75μl/L时粒径随体积浓度增加而增大，超过75μl/L时粒径随体积浓度的增加变化不明显；④絮凝体有效密度由粒径大小控制，粒径大，有效密度小，反之亦然，粒径和有效密度共同决定絮凝体静水沉速，有效密度和沉速与平均粒径之间均存在良好的幂指数关系。

We detected that EGF mRNA was expressed sflungly lii the oocyte, and is also found hi gmnulosa cells, the cell fium smaller foflicular expressed stronger than fium bigger one. In the corpus hemonbaglcwn corpus luteurn, lean type and pseudocorpus-luteum, EGF rnRNA was detected,, no distinct difference can be seen in them. The EGF mRNA expressed strongly in fimbria end, ampulla and isthmus of oviduct, in the big follicular stage, ovulation stage, pregnancy stage and spurius pregnancy stage, we can not see any distinct change in them, but hi the medium follicuar stage,it is weaker.

结果发现：猪卵母细胞中EGF的mRNA强烈表达，且小卵泡卵母细胞→中卵泡卵母细胞→大卵泡卵母细胞中，EGF的mRNA表达量有逐渐减少的趋势；猪卵泡的颗粒细胞中有EGF的mRNA表达，小卵泡颗粒细胞→中卵泡颗粒细胞→大卵泡颗粒细胞中，EGF的mRNA表达也有逐渐减少的趋势；猪卵巢中的红体、黄体、白体和假黄体中都有EGF的mRNA表达，看不出几部分的表达量有明显的强弱变化；猪输卵管伞部、壶腹部和峡部，都有EGF的mRNA表达，在大卵泡期，排卵期，孕期和假孕期都强烈表达，各期间看不出明显的强弱变化，中卵泡期表达较弱；猪子宫中EGF的mRNA在大卵泡期，排卵期，孕期和假孕期都强烈表达，看不出表达量的明显变化，而小卵泡期表达量明显减弱。

And the frontal technique is adapted to solve the FE equations. The techniques are studied to deal with the large slip frictional contactproblems between a deflectable body with large deformation and a rigid bodywith flat or curved surface. A new algorithm is presented to resolve such contactproblems, including incremental displacement constraints and force constraints,and the modules are programmed. The performances of tire under static load invertical loading state and camber state are analyzed by this method. And theexperiments were carried out at the same condition as used in analysis process.

研究了大变形柔性体与具有平面及曲面外形刚性体之间的大滑动摩擦接触问题，提出了求解这类接触问题的位移增量约束和主动力增量约束处理方法；编制了大变形柔性体与具有平面及曲面外形刚性体之间的大滑动摩擦接触问题求解模块；利用本文提出的大滑移接触问题处理方法，分析了轮胎在径向静载和静态外倾加载条件下受力和变形，并对部分分析结果进行了试验验证，验证结果表明，本文提出的位移增量约束和主动力增量约束处理接触问题的方法是正确可靠的，而且具有精度高、收敛性好、收敛速度快的优点。

Dialytic method was used to determine resveratrol release rate of Res-nanoliposomes in vitro. An in situ rat perfusion method was used to investigate the intestinal absorption of Res-nanoliposomes.

以动态透析法测定白藜芦醇纳米脂质体体外释药速率；以大鼠在体肠循环法研究白藜芦醇纳米脂质体在大鼠十二指肠、空肠、回肠及结肠中的吸收动力学特征及考察不同质量浓度(20，40，60，80 μg·mL-1)的白藜芦醇纳米脂质体在大鼠肠道的吸收行为。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Methods A wet hip joint's sample from corpse was scaned by CT and all images of every cross-section hip joint's layer was obtained, and an hip joint's model was contructed with Unigraphics NX 2.0 and Solid Works 2006 SP 0.0 software. The models were assembled when simulated total hip arthroplasty after total hip joint prosthetic and ischiofemoral ligament model had been constructured. Analysis was done on von Mises stress distribution and amount of total hip component when simulated seated leg-crossing manuver. The bone and metal components were meshed as rigid bodies, composed of three-dimensional, all-quadrilateral rigid body elements, and hip joint capsule ligament was fully three-dimensional, hexahedral continuum elements representations. Results The current form of this ischiofemoral ligament's reconstruction finite element model provided for multi-body contact, large displacement interfacial sliding, large deformation capsule ligament representation, and clearly reflected the real ischiofemoral ligansent's anatomy and biomechanical behavior. The maximum on Mises stresses at the joint interface was more than that fur an otherwise identical hardware-only construct.

选择成人尸体髋关节行CT成像得到髋关节每层横截面图像，提取边界坐标，利用有限元分析软件Unigraphics NX 2.0和Solid-Works 2006 SP0.0构建出髋关节三维有限元模型及人工髋关节假体，并模拟全髋置换术进行装配，将坐股韧带按其术中重建位置进行构建骨骼与金属模型采用三维十节点四面体实体单元进行网格划分，关节囊六面体连接单元划分，模拟坐位腿交叉动作载荷获取假体撞击过程的角活动度和相应的von Mises应力分布情况结果所构建的多体连接、大界面划移、大变形的坐股韧带重建有限元模型，客观反映坐股韧带真实解剖形态及生物力学行为，增加坐股韧带重建的模型其关节面的最大主应力值大于仅有金属的模型。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。