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Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.(2) the influence on the swelling ears of rats.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响:将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组(1.5 g/kg)、前列安颗粒中剂量组(3.0 g/kg)、前列安颗粒大剂量组(6.0 g/kg)及阳性药前列舒乐颗粒组(2.4 g/kg)6组,每组10只,各给药组大鼠连续灌胃给药7日,每日1次,模型对照组给予等容量蒸馏水,末次给药后30 min,在每鼠前列腺内注入1.5%角叉菜胶0.05 mL,24 h后断头处死大鼠,取致炎前列腺组织,镜下记录白细胞数和卵磷脂小体密度。

Objective To conduct Pharmacodynamics research of Qianliean pellet and provide the basis for the clinical medication. Methods (1) The influence on the rats with non-bacterial prostatitis of 1.5% carrageenin. Rats were divided randomly into the normal control group, the model control group, the Qianliean low-dose group (1.5 g/kg), mid-dose group (3.0 g/kg), high-dose group (6.0 g/kg), with 10 rats in each group. All groups were treated continuously for 7 days, once a day. The model control group was given distilled water, 30mins after the last medication, injects 1.5% carrageenin 0.05ml in each rat's prostate, after 24hs, behead execute the rats and record the white blood cell number and Lecithin density.

方法(1)对1.5%角叉菜胶致大鼠非细菌性前列腺炎的影响:将大鼠随机分为正常对照组、模型对照组、前列安颗粒小剂量组(1.5 g/kg)、前列安颗粒中剂量组(3.0 g/kg)、前列安颗粒大剂量组(6.0 g/kg)及阳性药前列舒乐颗粒组(2.4 g/kg)6组,每组10只,各给药组大鼠连续灌胃给药7日,每日1次,模型对照组给予等容量蒸馏水,末次给药后30 min,在每鼠前列腺内注入1.5%角叉菜胶0.05 mL,24 h后断头处死大鼠,取致炎前列腺组织,镜下记录白细胞数和卵磷脂小体密度。

Positive results of mutagenicity have been obtained with chrysophanol aloe-emodin emodin and chrysarobin in Salmonella /microsome assays.

致畸作用。沙门氏菌/微粒体中的致畸结果为阳性的有:大黄酚,芦荟-大黄素,大黄素,和驱虫豆素以上均为大黄的化学成份),大黄酸的结果为阴性。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降,而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高;但是,OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异;⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明:①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异,并以肝组织中的差异氨基酸数量为最多,包括各种生酮和生糖氨基酸水平在OP组的升高,说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一;②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸,说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异;③长期高脂饮食喂养后,动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异,这些菌群上的差别可能在动物体重增长的调节上产生影响;④与OR动物相比,OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩,管壁增厚呈空虚网状,生精细胞层次减少,间质细胞增生,但仍见有精子生成;高剂量组可见到精子呈异型性改变,细胞核浓缩深染,且随着摄入时间延长改变愈趋明显;F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩,间质增生明显,20个月时肾小球萎缩纤维化;F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生,淋巴母细胞增生活跃,20个月时脾小体减少,生发中心稀疏;F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润,晚期骨髓有核细胞减少,脂肪细胞增加。

Results: The hairy root was successfully induced and the hairy root culture system was set up; The opines assay was positive for mannopine and agropine; The result of determination showed that there were a lot of anthroquinone constituents in the rhubarb hairy root and the contents of rhein, aloe-emodin, emodin or 8-O-methylchrysophanol were respectively higher than those in wild plant root.

结果:诱导出了天山大黄发根,并建立了发根离体培养系;从发根中检测到甘露碱、农杆碱的存在;定量分析发现,天山大黄发根中含有多种蒽醌类成分,其中大黄酸、芦荟大黄素、大黄素、大黄酚-8-甲醚的含量分别高于原植物根中的含量。

But exist more insufficient , embody in mainly: Various kinds of structured according to the administrative division deal in facilities, the overall arrangement is unreasonable; Management system is not obeyed , the upper and lower responsibilities right relation is indeterminate , overstaffing in organizations, there are too many supernumeraries; The mechanism is unable to adapt to the turn of the market, the expenses are partial and large; The asset- liability ratio is too high, leaving unused , non-performing assets is too big in specific gravity, the heavy , whole efficiency of enterprises burden is low, compare with the big petroleum petro-chemical corporations of foreign countries, all have greater disparity in the respects , such as scale , business income , after-tax profit, per capita business income , per capita after-tax profit ,etc, especially the respects of personnel, disparity is greater.

但也存在许多不足,主要体现在:按行政区划构建的各种经营设施,布局不合理;管理体制不顺,上下责权利关系不明确,机构臃肿,冗员过多;机制无法适应市场变化,费用开支偏大:资产负债率过高,闲置、不良资产比重过大,企业负担沉重、整体效率低,与国外大的石油石化公司比较,在规模、营业收入、税后利润、人均营业收入、人均税后利润等方面都有较大的差距,尤其是人员方面,差距就更大了。

This paper introduces the quality control in the production of huge cemented carbide six -face anvils,which are applicated to synthesize artificial diamond in large size capacity.

概述了与人造金刚石合成大腔体相配套的硬质合金六面顶大顶锤的质量状况,分析了大顶锤质量与使用寿命的关系,从内部结构和外部质量两方面讨论了大顶锤质量控制的方向,提出了提高大顶锤质量、降低锤耗的几种方

The large-grained spherical copper powder is well compatible and binds securely with the small-grained spherical copper powder. Moreover, the large-grained copper powder has greater gaps between the grains.

小颗粒球形铜粉与钢基体接触面积大,烧结过程中结合牢固、充分,大颗粒球形铜粉与小颗粒球形铜粉烧结相容性好,结合牢靠,并且大颗粒铜粉之间的间隙大,改性聚甲醛可以深埋在大颗粒铜粉的间隙中,使改性聚甲醛工作更可靠。

The small-grained spherical copper powder is large in the contact area with the steel base and binds sufficiently and firmly in the process of sintering.

小颗粒球形铜粉与钢基体接触面积大,烧结过程中结合充分、牢固,大颗粒球形铜粉与小颗粒球形铜粉烧结相容性好,结合牢靠,并且大颗粒铜粉之间的间隙大,螺旋铜钉层可进一步加大这个间隙,改性聚甲醛可以深埋在螺旋铜钉及大颗粒铜粉的间隙中,使改性聚甲醛工作更可靠。

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