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In the process of laboratory study, oxycodone was prepared by oxidating thebaine at 6,14-position under oxydol, hydrodeoxidizing 7,8-position double bond and 14-position ether under palladium catalyst. Furthermore, N-methyl of oxycodone was isolated byα-chloro-ethyl chloroformate under anhydrous condition and protection of 14-position hydroxyl to obtain noroxycodone, which was further converted into methylnaltrexone by N-alkylation in presence of cyclopropyl bromomethane, then by isolating 3-position methyl of methylnaltrexone under boron tribromide, becoming hydrochloride to prepare target compound, natrexone hydrochloride.

实验室工艺方面,本文首先用双氧水氧化蒂巴因的6-和14-、在钯炭催化下加氢还原7-8双键和14-醚合成羟考酮,然后提出并优化了在无水和14-保护的情况下,用氯甲酸-α-氯乙酯脱去羟考酮的N-甲基合成去甲羟考酮,再用环丙甲基溴将去甲羟考酮的N-烷基化合成甲基纳曲酮,最后采用三溴化硼脱去甲基纳曲酮的3-甲基和成盐酸盐合成盐酸纳曲酮。

Salix matsudana, Ulmus pumila, Quermus mongolica, Populus alba×P.beroliensis and Betula platyphlla are frontal 5 tree species with weight value 90.37, 90.12, 88.12, 87.55 and 86.2 respectively, were used for farmland protection forest; Acer negundo, Salix matsudana, Juniperus rigida, Fraxinus mandshurica and Ulmus pumila are frontal 5 tree species with weight value 78.14, 76.92, 75.96, 74.72 and 74.56 respectively, were used for urban protection forest; Ulmus pumila, Salix matsudana, Populus alba×P.beroliensis, Acer negundo and Larix gemelinii are frontal 5 arbor tree species with weight value 80.07, 79.07, 77.5, 72.42 and 71.67 respectively, were used for road protection forest; Salix matsudana, Populus alba×P.beroliensis, Ulmus pumila, Larixgemelinii and Betula platyphlla are frontal 5 tree species with weight value 92.37, 88.72, 86.62, 85.82 and 85.7 respectively, were used for river protection forest; Fraxinus mandshurica, Larix gemelinii, Populus alba*P.beroliensis, Ulmus pumila and Salix matsudana are frontal 5 tree species with weight value 89.61, 8.35, 87.12, 85.56 and 80.15 respectively, were used for wood forest; Cornus alba, Prunus tomentosa, Primus triloba, Syringa obalata and Sambucus williamsii are frontal 5 shrubs with weight value 82.93, 81.23, 80.85, 78.38 and 77.78 respectively, were used for landscape forest; and Acer negundo,Malus baccata, Sorbus pohuashanensis, Prunus maackii and Prunus padus are frontal 5 arbors with weight value 82, 81.52, 80.3, 79.62 and 78.9 respectively, were used for landscape forest; Prunus salicina, Prunu

根据哈尔滨地区不同林种的功能要求,给出了不同指标的期望值,通过查询系统可以得到旱柳、榆树、蒙古栎、银中杨、白桦为符合农田防护林的前五的树种,权重值分别为90.37、90.12、88.12、87.55、86.2;糖槭、旱柳、杜松、水曲柳、榆树为符合城市防护林的前五的树种,权重值分别为78.14、76.92、75.96、74.72、74.56;榆树、早柳、银中杨、糖槭、兴安落叶松为符合道路防护林的前五的乔木树种,权重值分别为80.07、79.07、77.5、72.42、71.67;旱柳、银中杨、榆树、兴安落叶松、白桦为符合河岸防护林的前五的树种,权重值分别为92.37、88.72、86.62、85.82、85.7:水曲柳、兴安落叶松、银中杨、榆树、旱柳为符合用材林的前五的树种,权重值分别为89.61、88.35、87.12、85.56、80.15;红瑞木、毛樱桃、榆叶梅、紫丁香、接骨木为符合风景林前五的灌木树种,权重值分别为82.93、81.23、80.85、78.38、77.78,糖槭、山丁子、花楸、山桃稠李、稠李为符合风景林前五的乔木树种,权重值分别为82、81.52、80.3、79.62、78.9;李、杏、文冠果、山楂、野梨为符合经济林的前五的树种,权重值分别为88.85、80.88、73.25、69.35、63.77。

In this observational study, 65 children were treated with SLIT with a build-up phase of 11 days, culminating in a peak dose of 300 IR, and followed by a maintenance phase of 300 IR three times weekly. There were 51 boys and 14 girls; age range was 38 to 80 months (median age, 60 months). Allergens used were house dust mites in 42 patients, grass pollen in 11, olive pollen in five, Parietaria pollen in four, and cypress pollen in three patients. Adverse reactions and changes in the treatment schedule were compared in children aged 38 to 60 months vs those aged 61 to 80 months.

在这项观察性试验中,65接受SLIT的儿童在11天的适应期后,将剂量逐渐调整到最高300 IR,接著以每周3次,每次300 IR的剂量持续接受治疗;试验中包括51男童与14女孩,年龄介于38至80个月(平均年龄为60个月);其中有42病患以尘蹒、11以花粉、5以橄榄花粉、4以墙草、3以丝柏作为过敏原;年龄介于38至60个月的儿童,与61至80个月的儿童分成两组比较不良反应发生机率与治疗疗程的改变。

In this observational study, 65 children were treated with SLIT with a build-up phase of 11 days, culminating in a peak dose of 300 IR, and followed by a maintenance phase of 300 IR three times weekly. There were 51 boys and 14 girls; age range was 38 to 80 months (median age, 60 months). Allergens used were house dust mites in 42 patients, grass pollen in 11, olive pollen in five, Parietaria pollen in four, and cypress pollen in three patients. Adverse reactions and changes in the treatment schedule were compared in children aged 38 to 60 months vs those aged 61 to 80 months.

在这项观察性试验中,65接受SLIT的儿童在11天的适应期后,将剂量逐渐调整到最高300 IR,接著以每周3次,每次300 IR的剂量持续接受治疗;试验中包括51男童与14女孩,年龄介於38至80个月(平均年龄为60个月);其中有42病患以尘蹒、11以花粉、5以橄榄花粉、4以墙草、3以丝柏作为过敏原;年龄介於38至60个月的儿童,与61至80个月的儿童分成两组比较不良反应发生机率与治疗疗程的改变。

Many nanotwins were formed in this triangular region. HREM observations showed that nanotwinning dislocations were nucleated at noncoherent twin boundaries with the local stress concentration, and the nucleation is related to the dislocation dissociations at the boundary ledges. The proceeding of these nanotwins is the homogenous shears of 1/6 [11〓] twinning dislocations, which is that the trailing 1/6 [112] twinning dislocations repel the leading twinning dislocations to proceed in the (111) planes. Therefore, twinning dislocations at the twin tip appear to be on one side of twin, forming a noncoherent twin boundary with a semilenticular shape.

在此三角区域内发现许多纳米孪晶的存在,通过高分辨电镜手段观察到纳米孪晶中的孪生错是在具有原应力集中的非共格入射孪晶界上形核的,纳米孪晶的形核与界面的台阶错及其错分解反应有关,纳米孪晶的行进是1/6[11〓]孪生错均匀切变机制,即每一个(111)孪生面上对应一个孪生错,其中拖尾的1/6[11〓]孪生错将会推动领先的孪生错行进,于是在形变孪晶头部置的孪生错排列常常出现在形变孪晶的一侧界面,形成一个半透镜状的非共格孪晶界。

Results: The angle that adjusting the reference line on the transverse plane is 32. 85°±6.76°, on the coronal plane is 14.15°±9.02°. The facial canal appears "ㄟ" on double oblique imaging geniculate ganglion, tympanic segment, post lap segment, mastoid segment were showed clearly. The achievement ratio is 100%. The segment displaying on double oblique imaging is more than transverse plane, coronal plane and sagittal plane.

结果:面神经管双斜图像需要在横断参考图像上旋转参考线的角度为32.85°±6.76°,在冠状参考图像上旋转参考线的角度为14.15°±9.02°;在面神经管双斜图像上,面神经管表现为&ㄟ&形,由前向后同时显示出膝状神经节、鼓室段、后膝部和乳突段;面神经管双斜成像成功率为100%,面神经管行程的显示程度大于横断、冠状和矢状

At 1273K, the density of dislocations were considerably decreased in deformed TiAlMnNb alloy, twinning and 11 superdislocations were hardly observed, but few 1/212 superdislocations and 01 perfect dislocations were found in deformed TiAlMnNb alloy. In high temperature range, brittle-to ductile transition had already occurred in deformed TiAlMnNb alloy, unpinning and climbing were the dominant deformation behavior in TiAlMnNb alloy. In the same way as TiAlMnNb alloy, different distinguishing feature the dislocation configuration at low, intermediate and high temperatures emerged in deformed TiAlMnNbB alloy.

在中温区域,合金中错组态变化可分为两个小区域,在673K以下,合金的错组态有孪晶、1/210单错和少量的11超点阵错;这一温度区间内孪晶和错密度都大大提高,不同系统的孪晶相互交割阻碍了孪生的继续发展,不同方向的错相互交割阻碍错进一步滑移,同时孪晶界面也阻碍了错的运动。

Two of them are strongly influenced by traditional Chinese culture, and have close relationships with Taiwanese ceramists. The three Taiwanese ceramists all went to the United States to study, and all experienced American life. There are two female artists in this exhibition, and their works reflects their sensibilities and gender.

这三美国陶艺家,其中两对中国传统文化具有很大的兴趣且深受影响,与台湾陶艺家的接触也十分频繁且深入,另外三台湾陶艺家则皆曾赴美国学习陶艺创作,也皆深刻地融入当地的生活,对美国文化有相当的体验与了解;这六作者中包含了两女性创作者,她们让交叠的文化网路显得更为细腻且丰富;在年龄层方面,1940年代出生者有三、1950年代一、1960年代二,因此他们的作品也传达了不同世代间的对话内容与回应。

With regard to the lack of corresponding entity right backing for "execute the third party" according to the procedure law in current Chinese creditor"s subrogation system;the inconsistence between the entity law and the procedure law for the conditions to exercise creditor"s subrogation;the obscure effect of the exercising of the creditor"s subrogation;the indefiniteness of right and status of the parties in the subrogation proceeding and so on,it is suggested that amend the civil code,confine the creditor"s subrogation system,coordinate the rules in entity law and procedure law related to the debtees" to exercise their subrogation,define the creditor"s subrogation,the right and obligation of related parties in the procedure,perfect the rules in procedure law in order to provide proceeding procedure security for the realization of the creditors subrogation.

并针对我国现行债权人代权制度在程序法中&执行第三人&缺乏相应实体权利依据、实体法与程序法有关债权人代权行使条件规定不一致、债权人行使代权效力不清、当事人在代权诉讼中的地和权利不明确等诸多缺欠,提出了制定民法典确定债权人代权制度、协调实体法和程序法中关于债权人行使代权的规定、明确债权人代权诉讼相关当事人的权利义务、完善程序法规定为债权人代权实现提供诉讼程序保障的意见。

The company has independently developed, development, production of the products have six series, more than 400 varieties, including: wire and cable series: high-temperature compensation wire, control cables, fire-retardant cables, anti-corrosion cable, power cable, 6 ~ 110KV crosslinked power cables, computer cables, silicon rubber cables, high temperature cables, fire-resistant cables, low smoke low halogen, low smoke zero halogen cables, such as the main cable tray; Temperature Instrument Series: ITS900 in line with the International Temperature Scale and IEC standards A, B-grade Thermocouple , Explosion-proof Temperature Transmitter integration, intelligent all-input temperature transmitter; Pressure / Differential Pressure Meter Series: general pressure gauges, precision pressure gauges, pressure / differential pressure switch, the general stress / Differential Pressure Transmitter, 1151 , 3051 smart capacitive pressure / differential pressure transmitter; Level Instrument Series: glass / glass level gauge, quartz glass tube liquid level, the electric-contact level gauge, magnetic liquid level transmitter, magnetic liquid level switch, input-type hydrostatic liquid level transmitter, liquid level transmitter float electricity, etc.; Flow Meters Series: All English Intelligent Vortex Flowmeter, Turbine Flowmeter; Display Instrument Series: Intelligent Control LED digital display device, Intelligent LCD screen controlled device, Guangzhu instructions figures, such as conditioning Alarm.

公司自主研制、开发、生产的产品主要有六大系列、400多个品种,其中有:电线电缆系列:高温补偿导线、控制电缆、阻燃电缆、防腐电缆、电力电缆、6~110KV交联电力电缆、计算机电缆、硅橡胶电缆、高温电缆、耐火电缆、低烟低卤、低烟无卤电缆主电缆桥架等;温度仪表系列:符合ITS900国际温标和IEC标准的A、B级热电偶,防爆型一体化温度变送器、智能全输入温度变送器;压力/差压仪表系列:一般压力表、精密压力表、压力/差压开关、普通压力/差压变送器,1151、3051智能电容式压力/差压变送器;液仪表系列:玻璃管/玻璃板液计、石英玻璃管液计、电接点液计、磁性液变送器、磁性液开关、投入式静压液变送器、电浮筒液变送器等;流量仪表系列:全中文智能涡街流量计、涡轮流量计;显示仪表系列:智能LED数字显示调节控制仪、智能LCD界面显示调节控制仪、光柱指示数字显示调节报警仪等。

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In this section we look at the theory behind the techniques used in rotary polishing and the effects that they have on paintwork and the results achieved.

在这里看抛光剂使用背后的理论,到底是怎么一回事,我们如何用好的抛光机和好的使用技巧来达到好的效果。

I'll dig like a psychotic rodent if I have to.

那我就帮你挖到中国去。

In this paper, GIS is adopted to analyze the long-time series of ecological feature of Ommastrephes Bartrami and the relationship between Ommastrephes Bartrami fishery and oceanic environment factors in North West Pacific, based on the North West Pacific Ommastrephes Bartrami database.

本文利用地理信息系统,基于863项目建立的西北太平洋柔鱼综合数据库,对西北太平洋柔鱼渔场与海洋环境因子的关系,以及柔鱼生物、生态学特征进行了长序列数据分析研究。