似乎有

YMDD mutation: HBV YMDD mutation were developed in 12 lamivudine recipients, whereas the treated group had no incidence of HBV YMDD variation, there were significant difference between two groups (p=0.000). YMDD mutation resulted in increase of the mean HBVDNA levels (p=0.000), but no contribution to serum ALT diversification (p＞0.05). 2. Precore nt1896 mutation: Precore nt1896 mutation incidence had no difference between lamivudine recipients and objects who received combination therapy of Kidney-invigorating Granule and Marine Injection, and patients of HBeAg negative and HBeAg positive had a close incidence of precore mutation as well as. Precore nt1896 mutation had no influence on serum ALT level. The occurrence of precore nt1896 mutation contributed to serum HBVDNA load increased and worse response of HBVDNA extenuation. 3. HBV genotype: The baseline of serum HBVDNA gradually increase in turn of genotype B, genotype C and genotype B/C. Genotype B seemed to obtain higher rate of serum HBVDNA loss and HBeAg/anti-HBe seroconversion after combination therapy of Kidney-invigorating Granule and Marine Injection, differencing with lamivudine therapy.

疗效相关因素研究：1YMDD变异：对照组有12例检出YMDD变异，治疗组无1例检出，两组比较有显著性差异（P=0.000）；发生YMDD变异者血清HBVDNA和ALT水平均有所升高，HBVDNA平均水平高于非变异者（P=0.000）；血清ALT与非变异者无明显差异（P＞0.05）。2前C区nt1896变异：前C区nt1896变异发生率在治疗组和对照组以及HBeAg阴性和HBeAg阳性患者之间均无明显差异（P＞0.05）；1896c变异对血清ALT水平无明显影响；治疗组发生1896c变异者，其HBVDNA平均水平较之未变异者明显升高（P＜0.05），治疗后HBVDNA下降幅度明显低于未发生1896c变异者（P=0.000）。3HBV基因型：血清HBVDNA基础水平在B、C、B/C混合型间存在明显差异（P＜0.05），按B型、C型、B/C混合型依次升高；治疗组HBVDNA阴转率、HBeAg/抗-HBe血清转换率，B型似乎高于C型和B/C混合型，但无统计学意义（P＞0.05）；对照组HBVDNA阴转、HBeAg/抗-HBe改变在B、C、B/C混合型间无明显差异（P＞0.05）。

John and Josie's only child [00:28.23]young and handsome, fast and wild [00:33.58]join in the army at 18 [00:38.74]left the army at 18 [00:44.46]drift then from job to job [00:49.81]town to town and love to love [00:55.17]7 years forever, till young Jonnie came marching home [01:05.85]but Jonnie wasn't looking well [01:10.63]went into the hospital [01:16.41]days turned into several weeks [01:21.73]Jonnie kept on losing weight [01:27.10]Josie said that John sit down [01:32.64]John cried oh god,not my son [01:37.77]Jonnie left at 25 [01:42.39]hole as big as Jupiter [01:49.25] [01:50.10]there's nothing stronger than a love [01:55.21]John and Josie head for Jonnie [02:00.60]throughing his last birthday party [02:06.10]no one from the family came [02:10.04] [02:11.27]no one from the family came [02:16.42]turns John and Josie's grift to shame [02:21.58]shame to anger,anger pain [02:27.05]nothing they needed more now [02:30.28] [02:53.50]2 years's gone, [02:55.38]the telephone is ringing in the dim the damn [03:04.07]beneath the world and cluser face [03:08.93]but John had punched the day he learned [03:14.49]that Jonnie he wouldn't live much longer [03:20.06]now a voice said to his father [03:24.74]Jonnie have a baby here [03:30.11]no one seems to want him [03:33.90] [03:35.94]baby doesn't have his parents [03:40.49]2 months old and with a pair of eyeless [03:46.65]Josie grabbed the phone from John [03:51.79]two of them said yes yes yes [03:57.51]so John and Josie over 60 [04:02.52]taking in a brand-new baby [04:07.78]named Paul Antonio [04:13.29]Jonnie would've loved him [04:18.24] [04:18.99]nothing stronger than a love [04:23.90]John and Josie head for Jonnie [04:29.32]the same love at they've fall apart [04:34.59]they starting up to win again [04:39.71]and on the fear that same could happen [04:45.27]losing paul before his time comes [04:50.53]John and Josie looked right past it [04:55.51]they're basketing in love's mighty presents [05:01.34]John and Josie don't have time [05:07.98]they're basket in love's mighty presents

约翰和Josie歌词翻译悬赏分：5 -离问题结束还有13天22小时 [00 ：23.00]约翰和Josie的独生子 [00 ：28.23]年轻和英俊，快速和狂放 [00 ：33.58]加入军队在18 [00 ：38.74]被留下军队在18 [00 ：44.46]漂泊然后从工作对工作 [00 ：49.81]镇对镇和爱到爱 [00 ：永远55.17] 7年，年轻Jonnie来了前进在家 [01 ：05.85]，而是Jonnie没有很好看 [01 ：10.63]进入医院 [01 ：16.41]天把变成几个星期 [01 ：21.73] Jonnie在丢失的重量保持了 [01 ：27.10] Josie说约翰坐下 [01 ：32.64]约翰哭泣oh神，没有我的儿子 [01 ：37.77] Jonnie离开在25 [01 ：42.39]孔一样大象木星 [01 ：49.25] [01 ：50.10]那里比爱是没什么强 [01 ：55.21]约翰和Josie头为Jonnie [02 ：throughing他的前次生日聚会的00.60] [02 ：06.10]没人从家庭来了 [02 ：10.04] [02 ：11.27]没人从家庭来了 [02 ：16.42]转动约翰和Josie的grift到羞辱 [02 ：21.58]羞辱愤怒，激怒痛苦 [02 ：27.05]他们现在需要的没什么 [02 ：30.28] [02 ：去的53.50] 2年的， [02 ：55.38]电话在昏暗敲响该死的 [03 ：04.07]在世界和cluser面孔之下 [03 ：08.93]，但约翰猛击了他学会的天 [03 ：14.49]那Jonnie他长期不会居住 [03 ：20.06]声音对他的父亲现在认为 [03 ：24.74] Jonnie这里有一个婴孩 [03 ：30.11]没人似乎想要他 [03 ：33.90] [03 ：35.94]婴孩没有他的父母 [03 ：40.49] 2个月老和以一个对无眼 [03 ：46.65] Josie劫掠了电话从约翰 [03 ：51.79]二他们是认为 [03 ：57.51]如此约翰和Josie 60 [04 ：采取在一个全新的婴孩的02.52] [04 ：07.78]命名的保罗Antonio [04 ：13.29] Jonnie将爱他 [04 ：18.24] [04 ：18.99]没什么强比爱 [04 ：23.90]约翰和Josie头为Jonnie [04 ：29.32]同一爱在他们有散开 [04 ：34.59]再开始由胜利决定的他们 [04 ：39.71]和在恐惧同样可能发生 [04 ：45.27]丢失的保罗在他的时间之前来 [04 ：50.53]约翰和Josie看起来正确的过去它 [04 ：55.51]他们在爱的强大礼物basketing [05 ：01.34]约翰和Josie没有时间 [05 ：07.98]他们是篮子在爱的强大礼物

Penguin was notified about the selection three weeks in advance of the announcement, an improvement over the single week it was given to print and distribute copies of Icy Sparks by Gwyn Hyman Rubio in 2001, said publicity director Maureen Donnelly.

纵使美国社会有千般不好，一个能够使欧普拉诞生，能够使欧普拉发挥影响力，能够使普罗大众从电视萤幕前偶尔探头看看白纸黑字的书本的社会，看起来似乎就是比我们有了更多「向上提升」的可能。

If your cat seems to be feeling under the weather, he most likely has a hairball problem.

如果您的猫似乎是感觉，根据天气，他最有可能有一个hairball问题。

His eyes suddenly sparkled with new life and haltingly he introduced himself.

有一个尖锐的斗争与我沟通，但有一件事他似乎决心发言权。

Gerasim accepted Pierre's taking up his abode there with the imperturbability of a servant, who had seen many queer things in his time, and he seemed, indeed, pleased at having some one to wait upon.

素来就有仆人伺候人的习惯的，一生见过许多稀奇古怪事情的格拉西姆，对皮埃尔迁来暂住并不吃惊，而且，有一个人让他伺候似乎很满意。

I return special nevertheless flexible language to did not try it seems that, if experience mine indite a paragraph of record of paragraph of period comes down, come with the character transcribe so a contrail, do not have the film of playwrite like, where weather plays where where to pat, direction does not have method, have terminus but do not know He Fang.

不过 专门的软文我似乎还没尝试，如果把我的经历写成文章一段段时期的记录下来，用文字来录制这么一个轨迹，像一部没有编剧的电影，哪天演到哪里就拍到哪里，有方向没有路径，有终点但不知何方。

When he dined with his sister that evening, Madeline helped herself to a cigarette from his pack on the table, and lit and smoke it inexpertly.

如果说谁有权利希望自己能解决大多数物理学家似乎无法解决的问题，那么他就有这种权利。

While there are many different interpretations of our body language, some gestures seem to be universal.

尽管我们的身体语言可以有多种不同的解释，仍然有一些姿势似乎是全球通用的。

Hester had schooled herself long and well; she never responded to these attacks, save by a flush of crimson that rose irrepressibly over her pale cheek, and again subsided into the depths of her bosom.

但也有时候--好多天有这么一次，或者要好几个月才有这么一次，她会感到一双眼睛--一双人类的眼睛望着她那耻辱的印记，似乎能给她片刻的宽慰，象是分担了她的一半痛苦。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。