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OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数,优化给药方案,设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式,CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发,在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物,适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上,结合病人个体特征,以1,2个血药浓度作为反馈,即可拟合估算个体药动学参数,优化给药方案结论经初步应用,CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

In this paper,a distributed parallel computation,which is based on the domain spliting and the block chaotic relaxation methods,is discussed under the network environment.

本文讨论网络环境下的分布式并行计算,以区域分裂法与混乱块迭代为基础,在Novell网上利用多台微机作分布式计算。

The article in recent years the research progress of disease of oral cavity of TP prevention and cure makes one overview. The compositive TP of the basic research 1.1 TP of 1 TP is the floorboard that phenolic apperception of a kind of many hydroxyl closes matter, 25% what hold tea dry weight about, its are main component includes to express gallnut of gallnut catechu element gallnut of element of catechu of gallnut of acerbity ester, watch, watch catechu element is acerbity element of catechu of ester, watch, express gallnut of gallnut catechu element among them acerbity ester content is highest, occupy the 80%[1] of catechu element about, fighting oxidation with its unique element structure, fight the position with fight the respect such as tumor to have choppy, significant. The 1.2 TP absorption in oral cavity and metabolization Lee [2] is measured normally inside a hour after healthy person is chewing green tea Xie Huo contains juice of gargle green tea, content of the TP in saliva is very high, after observing green tea passes salivary enzymatic hydrolyze, TP is slow release and in oral cavity;Yang of local play action [the salivary level after 3] checked 6 volunteers to drink tea, chroma of the TP in making clear the saliva after drinking tea as a result is serous TP pH indicator 2 times, and the salivary TP concentration that contains gargle tea solution a few minutes to be able to produce higher level, and TP can be absorbed through oral cavity mucous membrane.

本文就近年来TP防治口腔疾病的探究进展作一综述。1 TP的基础探究1.1 TP的组成TP是一类多羟基酚类化合物的总称,约占茶叶干重的25%,其主要成份包括表没食子儿茶素没食子酸酯、表没食子儿茶素、表儿茶素没食子酸酯、表儿茶素等,其中表没食子儿茶素没食子酸酯含量最高,约占儿茶素的80%[1],并以其独特的分子结构在抗氧化、抗突变、抗肿瘤等方面占有重要的地位。1.2 TP在口腔中的吸收和代谢Lee等[2]测得正常健康人在咀嚼绿茶叶或含漱绿茶液后的一个小时内,唾液中TP含量很高,并观察到绿茶通过唾液酶水解后,TP缓慢释放并在口腔局部发挥功能;Yang等[3]检查了6位志愿者饮茶后的唾液水平,结果表明饮茶后唾液中TP浓度是血浆TP浓度的2倍,而含漱茶溶液几分钟即可产生更高水平的唾液TP浓度,且TP可通过口腔黏膜吸收。

This article analyses the main customization problem of existing products for populaces in China based on the diagnoses of products and requirement of popular electronic map, and brings forward a suit of ways and means to improve popular electronic map's customization by a lot of software interface. This article can be referenced by enterprise or confrere.

本文在民用电子地图市场的需求和现有民用电子地图产品市场调研的基础上,分析了现有国内民用电子地图在用户化工作方面存在的主要问题,并以实际界面的形式对如何提高产品用户化程度阐述了自己的思路和方法,供从事电子地图开发经营的企业和同仁参考。

Directed by the military strategy guide lines, in order to meet the demands of the effective support and the development of the need in the reality and future, based on the quantitive literature investigation and theoretic research, This thesis systematically analyzed the subjective and objective factors influencing the capability of first aid, methods like experts consultation, systematic analyse are used to put forward the new technic cure measures for the corpsman in wartime first aid in the future combat.

本课题旨在以新时期军事战略方针为指导,围绕实现"保障有力"的总要求,着眼于现实与未来的发展需要,在大量文献调研和理论研究的基础上,系统分析了影响急救能力的主客观因素,并结合专家咨询、系统分析等方法提出了未来作战时,我军卫生员在实施战场急救时所采取的新的技术救治措施,并通过实证研究得到了证实。

However, the soil-borne plant pathogen Agrobacterium tumefaciens uses the type IV secretion pathway to deliver its oncogenic T-DNA that causes crown gall tumors on many plant species.

作 者将介绍加vir基因的诱导、T-DNA的加工、T-DNA的转移,以及 T-复合体运输的装备等方面的最新研究进展,以探讨农杆菌-植物间基因转移的分子基础。

In chapter three, the main point is that further explaining the trait of regional culture, visual features and elements of development. All this renders people recognizing the vision of the creative postcard on the basics of regional culture. Actually The most important part of the paper is chapter four and chapter five.

第三章以地域文化与视觉规律为主线,对地域文化特征,视觉特征和元素开发等作了初步的探讨,使大家在认识地域文化特征的基础上,了解视觉的特点。

This thesis attempts to study the cult of Dionysus in ancient Greece, based on available ancient literature and archaeological materials.

本文是以古典文献和考古发掘资料为基础、对古希腊狄奥尼索斯崇拜这一宗教现象所作的一项专题研究。

In this thesis, the radiation principle and the structure of slot antenna are studied and the impacts on its performance of every structure parameter in a slot antenna design are analyzed. On this foundation, a design plan of planar slot array antennas is proposed. The design has some structural feature as follows:(1) with different dielectric layers and microstrip line structure to guide the electromagnetic wave effectively;(2) the feeding network formed of microstrip line can match with the radiating slots expediently;(3) in order to increase the bandwidth of the antenna, the wider slot and branched feeding microstrip line are adopted to form a double resonance.

本文对缝隙辐射的原理、缝隙天线的结构作了探讨,分析了缝隙天线设计中各结构参数对其性能的影响,并在此基础上提出一种平面型缝隙天线的设计方案,它具有以下的特点:(1)采用分层结构,以不同的介电系数和微带线结构形成对电磁波的有效引导;(2)利用微带线构成馈电网络可以方便地与辐射缝隙进行匹配;(3)增大缝隙的宽度,并利用馈电微带线的枝节形成双谐振,以增加天线的带宽。

The other concerns the means suggested for educating this person and rational for the recommended means. Basing on the philosophical theory of the relationship between knowledge and morality and the fact that efforts inmany countries engaged in a direct training of the will disregard students intellectual development, Maritain not discusses the direct and indirect moral formation but makes an important distinction between the educational tasks of school and those of family and church.

以知识与道德关系为理论基础并以各国进行的直接的意志训练而漠视了智力发展的事实为依据,马里坦具体论述了道德的直接形成和道德的间接形成两种道德教育方法,并在学校与家庭、教堂在道德教育上的作用作了重要区分。

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歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车,和一双合并为一移交&整个lotta爱&。

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