代谢物

Objective : To detect the serum level of triglyceride、total cholesterol、low-density-lipoprotein-cholesterol、plasma viscosity,fibrinogen 、the level of plasma tissue plasminogen activator,plasminogen activator inhibitor-1(PAI-1) and calculate the score of nervous impairment of acute ischemia apoplexy patients ; so as to compre- hend changes of lipid metabolism、hemorheology and fibrinolysis function of AIA patients and it relation of the condition degree, and to investigate relationship between the above-mentioned microcosmic indexes and phlegm blood stasis syndrome.

目的：通过观察急性缺血性中风患者血清甘油三酯、胆固醇、低密度脂蛋白、血浆粘度、纤维蛋白原、血浆组织纤溶酶原激活物及其抑制剂-1（PAI-1）和评定神经功能缺损程度积分以了解急性缺血性中风患者脂质代谢、血液流变性及纤溶系统功能的变化及其与病情程度的关系，并探讨上述微观指标与痰瘀证的关系。

Those biodegradable materials finally form into CO2 and H2O via culture of tricarboxylic acid cycle, which can be excreted from lung, kidney, and skin. Hydroxyacetic acid is a metabolic product of amino acids. Therefore, velocity of bioldegradable materials can be controlled in vivo. The recent contraception focuses on discover a sustained release system of biodegradable materials.

生物可降解材料包括聚乳酸、聚ε-己内酯、乳酸-羟基乙酸共聚物等，这些材料有很好的生物相容性，植入体内后可经生物降解成乳酸单体，经三羧酸循环后最终成为CO2和H2O，经肺、肾、皮肤排泄，羟基乙酸也是机体氨基酸代谢产物，而且生物可将解材料在体内降解速度是可控的，用生物降解聚合物作为药物载体的缓释避孕系统是目前材料学以及避孕节育研究的一大重点。

Toxicity and species difference are the other problems of CPTs. Homocamptothecins , a novel CPT analog which contain an expanded seven-membered β-hydroxylactone, have shown elevated antitumor activity and improved stability without species difference.

高喜树碱是近年来刚刚出现的一类CPT类似物，其特征是将α—羟基内酯环改造成七元的β—羟基内酯环，不仅活性明显提升，而且体内代谢稳定性也大大提高，并且不存在种属差异现象。

Results Several new hydroxylate metabolites and its sulfate conjugates were found and identified in rat urine.

结果 在大鼠尿中检测到几种尚未在国内外报道过的羟基化代谢产物及其硫酸酯轭合物。

Gap junctional intercellular communication is important in the regulation of cellular proliferation and tissue homeostasis.

内容摘要近年来的研究认为抑制细胞缝隙连接间通讯是促癌物的一种重要特性。代谢协同试验是测定GJIC的方法之一。

Limonoids, mainly found in the Rutaceae and Meliaceae families,are a group of chemically related triterpene substances and derivatives of secondary metabolism of plants.

柠檬苦素类似物主要存在于芸香科和楝科植物中，是一类三萜类的物质，是植物次生代谢产物之一。

Raw enzyme was extracted after the bacteria were ultrasonically broken, and its 2-oxoalde-hyde reductase activity was detected by HPLC and UV absorbency spectrum in the presence of NADH and methylglyoxal as a substrate.

破碎该菌细胞后提取粗酶，以甲基乙二醛作反应底物，在还原性辅酶Ⅰ存在条件下，紫外光谱和HPLC的分析表明，该菌能代谢甲基乙二醛；并对其产酶条件进行了研究。

Characterize the chemical structure of these compounds using traditional wet chemistry techniques as well as Synchrotron-sourced Fourier transform infrared microspectroscopy

应用常规化学方法和同步红外显微光谱仪鉴定生物活性物的化学构成；杆菌O157：H7 效果和调节瘤胃代谢功能的关系

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

The biotransformation of butyl phthalide and its analogues was studied.

本文研究了芹菜甲素及其几个类似物的代谢转化。

I can still vividly recall the impressive scenes you gave. You were among my friends and relatives who accompanied me from my house to the seaport and when the porters were slow to show up, you obligingly carried my suitcase for me.

你对我的种种感人情意，使我记忆犹新，那天你随着我的亲友从家里送我上轮船，搬运工迟迟不来，你毅然替我提着皮箱上船。

St. Nicholas became the patron saint of Russia, where he was famous for his red cape, flowing white beard, and bishop's mitre.

圣尼古拉成了俄罗斯人的守护神，在那里，他以身披红斗篷，留着飘逸的白胡须，戴着主教法冠而闻名。