代谢物

The aims of this study were:(1) to find methods to analyze 7-tocopherol and its metabolites;(2) to study the kinetics of 7-tocopherol metabolized in the S9 of male SD-rat liver in vitro;(3) to compare the differences of 7-tocopherol metabolized in the liver S9 of male SD-rat, male Brazil turtle and male cobia, respectively.

研究内容主要是：(1)γ-生育酚代谢物的分析方法；(2)γ-生育酚在雄性SD-大鼠肝S9的体外代谢动力学；(3)比较γ-生育酚在不同代谢水平动物的肝S9中代谢的差异。

Methods:a solid-phase extraction and gas chromatography-mass spectrometry procedure for the simultaneous detection of tramadol and its main metabolite in urine has been developed.results:the linearity of the tramadol solution from 0.1 g/ml to 100 μg/ml is fine ,and correlation coefficient is 0.9957.the average recovery was 99.21%,and the relative sandard deviation was 2.83%.conclusion:it is a rapid,simple,accurate and sensitive method.it is also an effective method for rapid detection whether there is tramadol in urine of druggy.

采用c18固相萃取法对尿中曲马多原体及其主要代谢物进行提取，利用gc-ms对其进行检测。结果：线性范围为0.1~100μg/ml（r=0.9957，n=6），平均回收率为99.21%，相对标准偏差为2.83%，最低测量限为 0.1 g/ml 。结论：本实验研究建立了尿中曲马多及其代谢物的快速、简便、准确、灵敏的检测方法，可作为快速检测吸毒人员尿中是否含有曲马多的一种有效的方法。

Moreover, coefficients of variation of the ratios and the metabolite changes in each type of tumors were calculated.

并且，计算每一种肿瘤的代谢物比值及代谢物浓度变化的变异系数。

In the first part of this article, an HPLC method for the determination of nimodipine and its major metabolite was developed and applied to the study of the metabolism of nimodipine as well as enzyme kinetics in human liver microsome.

本文第一部分建立了人肝微粒体中尼莫地平及其代谢物的HPLC测定法，并用本法研究尼莫地平在人肝微粒体内的代谢及其代谢酶动力学，选择性CYP450酶抑制剂对尼莫地平代谢的影响。

It contains: starch 3%, glucose 2%, soybean meal 2%, peptone 0.5%, fish meal 0.5%,2S040.15%, MgSO4 0.1%, KI-12P040.04%, CaCO3O.4%, soybean oil 1%, propyl alcohol 0.4%(added at the 18th hour of batch fermentation).

发酵培养18小时补加0.4％的正丙醇。原始霉素的发酵存在碳源分解物代谢阻遏现象和氮源分解代谢物阻遏现象。

The amniotic fluid and allantoic fluid of chicken embryo have been analyzed and the resonances of most substances in them were assigned by 1-dimention and 2-dimention Nuclear Magnetic Resonance methods. This work could be the basis of quantitative analysis of metabolites and studying the metabolites changing between the amniotic and allantoic fluid during the hatching process. Also, it provided a new way to study the process of embryo developing.

用一维及二维液体高分辨核磁共振(Nuclear Magnetic Resonance，NMR)方法综合分析了鸡胚羊水和尿囊液的成分，对其中的大多数谱峰进行了归属，发现了一些未经报道的小分子代谢物，为研究胚胎发育过程中各个胚囊中体液的交换和小分子的代谢以及进一步对发育过程中代谢物含量变化的定量研究打下了基础，并为研究胚胎发育的过程提供了新的思路。

GC-MS or LC-MS is a kind of modern,fair chemical analytical technique,which combine higher separation ofChromatography with strong identification of Mass.It was applied in new drug research including concentration determination,impuritycheck,pharmacokinetic,anabolite analysis and so on.The paper reviews their application examples for recent years and shows itsdevelopment future.

气一质联用法和液一质联用法将色谱的高分离性能和质谱的高鉴别特点相结合，组成了较完美的现代分析技术，在新药研究的含量测定，有关物质检查、质量标准制定以及药物动力学研究的代谢物分析、药物及代谢物的体内浓度分布等试验中，成为有力的分析工具，文章综述了近年来色谱一质谱联用在以上领域的应用实例，展示了它的发展前景。

Investigation of major metabolic pathways of SFZ-47 in animals The metabolites of SFZ-47 in rabbit urine following oral administration were separated and detected with HPLC and LC-MS methods. On the basis of the chromatographic behavior and mass spectra of the metabolites as well as biotransformation pathways of drugs with the partial structure of SFZ-47, the hydroxylic derivative 4-(3H-1, 2- dihydro-1-pyrrolizinone-2-methylamino benzyl alcohol and the carboxylic derivative 4-(3H-1, 2-dihydro-1-pyrrolizinone-2-methylamino benzoic acid of SFZ-47 were proposed as two potential metabolites and were synthesized.

在动物体内主要代谢途径的确定用HPLC和LC-MS对家兔口服SFZ-47后尿中的代谢物进行了分离、检测，根据代谢产物的色谱和质谱行为以及与SFZ-47有类似结构部分的其它药物的代谢途径，推测其羟基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲醇]与羧基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲酸]是两种可能的代谢产物，遂用化学方法合成了这两种衍生物。

Chinese Academy of Inspection and Quarantine, Beijing 100025, China Abstract: This article reviewed the development of fipronil and its metabolites, emphasizing the fate of environment, action of fipronil and toxicology of antimer and metabolites.

中国检验检疫科学研究院，北京 100025 摘要：综述了氟虫腈及其代谢物近年来的研究进展，涉及氟虫腈及其代谢物在环境中的迁移与转化、氟虫腈的作用机理、对映体的毒性差异。

Clinical Study on treatment of prostatic carcinoma high Intensity hocused ultrasound combined with hormone in the;2. To evaluate the roles and mechanism of IGF-2 on fetal growth and development during late gestation, pregnant ewes and rats were employed to investigate relationship between IGF-2 and metabolites, hormones of pregnant animals and their fetuses.

本文以绵羊、大鼠为实验对象，观测围产期妊娠母羊、胎儿和新生儿血浆IGF-2水平的动态变化及其与其它内分泌激素和代谢物水平之间的相关性，并研究了给予外源性IGF-2片段、葡萄糖、胰岛素和皮质醇对血浆IGF-2、胰岛素和代谢物水平影响，综合分析IGF-2在动物胚胎、新生儿生长发育中的作用，着重探讨IGF-2与营养代谢和内分泌之间的关系以及分泌的调节因素。

I can still vividly recall the impressive scenes you gave. You were among my friends and relatives who accompanied me from my house to the seaport and when the porters were slow to show up, you obligingly carried my suitcase for me.

你对我的种种感人情意，使我记忆犹新，那天你随着我的亲友从家里送我上轮船，搬运工迟迟不来，你毅然替我提着皮箱上船。

St. Nicholas became the patron saint of Russia, where he was famous for his red cape, flowing white beard, and bishop's mitre.

圣尼古拉成了俄罗斯人的守护神，在那里，他以身披红斗篷，留着飘逸的白胡须，戴着主教法冠而闻名。