代谢物

Suggest what the metabolite might be, and why the metabolism of toluene is different from that of benzene.

说明代谢物可能是什么，并且说明为什么甲苯的代谢物和苯的代谢物不同。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

BE a person machine body because of metabolism but creation various metabolism thing metabolism don't go out, cause'common cold', mouth cavity ulcerate, various burning disease, various wet, oil, stem skin disease, Sao Yang, ache etc. machine quality disease, these be"don't disease";Person machine body the organ have no decrepitude, but the body falsely can't go out various metabolism thing metabolism not, can also cause the paroxysm relapse and these be also"don't disease".

是人机体因新陈代谢而产生各种代谢物代谢不出去，就导致'感冒'、口腔溃疡、各种炎症、各种湿性、油性、干性皮肤疾病、瘙痒、疼痛等器质性疾病，这些就是"未病"；人机体器官没有衰老，但身体虚，不能把各种代谢物代谢不出去，也可导致疾病的复发，这些也是"未病"。

The results show that the hyperthyroidism group has elevated levels of choline, glucose and declined levels of VLDL, LDL, cholesterol, lactate, glycoprotein and alanine in serum samples relative to the healthy group. In urine samples, the hyperthyroidism group show increased levels of glucose, citrate, taurine and creatinine as well as decreased levels of hippurate, trimethylamine-N-oxide, formate and succinate.

结果表明，甲亢组血清中的胆碱、葡萄糖和三甲胺等物质的含量升高，而VLDL，LDL和胆固醇等脂质以及乳酸、糖蛋白和丙氨酸等代谢物的含量下降；甲亢组尿液中的葡萄糖、柠檬酸、牛磺酸以及肌氨酸等代谢物的含量升高，而马尿酸、TMAO、甲酸和琥珀酸等代谢物的含量下降。

To our knowledge, reverse phase of high performance liquid chromatography was firstly developed to analyze the metabolites of 7-tocopherol with ideal results. Meanwhile, Gas chromatography/Mass chromatography were used to analyze the structures of unknown metabolites of 7-tocopherol and a main unknown metabolite was identified as a side chain ω- hydroxylate of 7-tocopherol.The kinetic results of of 7-tocopherol reacted in the S9 of male SD-rat liver showed that the optimal time was 45 min; the optimal concentration of S9 5 mg/ml; the optimal concentration of NADPH 1 mM; and the optimal concentration of 7-tocopherol 8 μg/ml. The result of γ-tocopherol metabolized in the S9 of male SD-rat was the best; male Brazil turtle better; and male cobia worst.

本试验首次确立了γ-生育酚代谢物的RP-HPLC分析方法，结果理想且重现性好；用GC／MS对γ-生育酚的未知代谢物结构进行分析，判断其中一种主要的代谢物为γ-生育酚侧链初级羟基化代谢物；γ-生育酚在雄性SD-大鼠肝S9的代谢动力学表明，本实验条件下代谢反应的最佳时间为45min，S9浓度为5mg／ml，NADPH浓度为1mM，γ-生育酚浓度为8μg／ml；发现γ-生育酚在雄性SD-大鼠肝S9中代谢最高，雄性巴西龟次之，雄性军曹鱼最低。

In conclusion, the hepatotoxicity of clivorine is caused by the hepatotoxic pyrrolic metabolites formed in vivo. CYP3A involved in the formation of pyrrolic metabolites and plays a key role in metabolism-induced hepatotoxicity of clivorine.

Clivorine的肝毒性是其在体内形成的肝毒性吡咯代谢物所致，CYP3A参与了肝毒性吡咯代谢物的形成并在clivorine的代谢致毒方面发挥了关键性的作用，因此CYP3A的诱导剂和抑制剂可以影响肝毒性吡咯代谢物的形成，从而影响clivorine的肝毒性。

The major in vitro metabolites of clivorine found in the incubation mixture are two non-pyrrolic metabolites(M1 and M2) and the formation of hepatotoxic pyrrolic metabolites from clivorine is only the minor in vitro metabolic pathway of clivorine in female rats.

山冈橐吾碱在雌性大鼠肝微粒体内的主要代谢物为两个非吡咯代谢物M1和M2。与雄性大鼠不同，生成肝毒性的吡咯代谢物为其次要的代谢途径。

Nim was rapidly metabolized and three metabolites of Nim were isolated and identified in human liver microsomes. These are dehydrogenated metabolite of dihydropyridine ring of Nim (M1), demethylated metabolite of lateral chain of dihydropyridine ring of Nim (M2) and the dehydrogenated and demethylated metabolite of Nim (M3), respectively.

Nim在人肝微粒体内被迅速代谢成3个代谢物，分别是Nim二氢吡啶环脱氢代谢物M1，二氢吡啶环侧链脱甲基代谢物M2，二氢吡啶环脱氢及其侧链脱甲基代谢物M3。

Determination of Tyrosine in Urine Spectrophotometric Method;2. For chemical pre-extraction, MSTFA/TMSL derivatization reaction, GC/MS analysis, it is confirmed that two main metabolites (19-no-randrosterone and 19-noretiocholanolone) were found in nandrolone urine.

本文对合成的19-去甲雄烷醇酮的四个差向异构体混合物进行气相色谱分离，对诺龙和炔诺酮用药后，留取的人尿样通过化学预处理，MSTFA/TMSI衍生化反应，GC/MS分析，确证了尿样中诺龙的两个主要代谢产物为19-去甲雄酮和19-去甲原胆烷醇酮，炔诺酮的两个主要代谢物是四氢炔诺酮的两个形式，可能是3α-OH-5α-THINE和3α-OH-5β-THINE，在炔诺酮代谢前期，还发现有诺龙的上述两个代谢物存在。

The physiology of the skin machine body for the sake of the environment in the maintenance stability, but eject a body metabolism creation of metabolism thing BE'grease', summer perspire many various skin disease light or good, autumn perspire little metabolism thing metabolism don't go out, various skin disease made, this be the skin machine body of various burning disease.

皮肤机体的生理为了维持内环境稳定，而排出身体代谢产生的代谢物是'油泥'，夏天出汗多各种皮肤病就轻或好了，秋天出汗少代谢物代谢不出去，各种皮肤病就犯了，这就是皮肤机体的各种炎症。

I can still vividly recall the impressive scenes you gave. You were among my friends and relatives who accompanied me from my house to the seaport and when the porters were slow to show up, you obligingly carried my suitcase for me.

你对我的种种感人情意，使我记忆犹新，那天你随着我的亲友从家里送我上轮船，搬运工迟迟不来，你毅然替我提着皮箱上船。

St. Nicholas became the patron saint of Russia, where he was famous for his red cape, flowing white beard, and bishop's mitre.

圣尼古拉成了俄罗斯人的守护神，在那里，他以身披红斗篷，留着飘逸的白胡须，戴着主教法冠而闻名。