代谢

Compared to the control animals, the rats treated with AC showed increased levels of citrate, 2-oxoglutarate and cis -aconitate, and decreased levels of hippurate and phenylacetylglycine in the urine. Such metabolic changes may have reflected, respectively, the changes in body energy metabolism and in the metabolism of intestinal flora in response to AC treatment.

结果表明灌胃给药后代表能量代谢的柠檬酸，2-酮戊二酸（2-oxoglutarate）和顺乌火酸（ cis -aconitate），反应肠道菌群代谢状况的马尿酸盐和苯乙尿酸出现异常，并且这些变化在给药后0~8 h达到最大，16 h后基本恢复正常。

In.particular, genes involving in histidine biosynthesis (hisJ、 hisG、 hisF、 hisH、 hisB and hisD) were significantly repressed in mutant strain, while other 5 genes such as fur-, ftn-, dps, yecl and bcp which related to iron homeostasis were up-regulated. In addition, after hns gene was knock-out, expression of sjh but not stpA, which encodes H-NS paralogues, increased significantly.

比较特别的是，6个参与组氨酸合成与代谢的基因hisJ、hisG、hisF、hisH、hisB以及hisD在突变体表达下调，而与铁代谢有关的5个基因fur、ftn、dps、yecI和bcp的表达明显上调。

Three major metabolites were identified as 3-OH-HBP,γ-OH-HBP and a hydroxylate on its benzene ring.

确认了芹菜甲素在肝微粒体中三个主要代谢产物及三个次要代谢产物。

However, the 3-and γ-positions were found to be the active metobolism sites either in vitro or in vivo, while no hydroxylate on benzene ring was detected for most of them.

但总的说来，不论在体外，还是在体内转化中，3-位，γ-位是这类化合物代谢的活性位点，而苯环上4-、5-位几乎均未发现有代谢物生成。

Diabetes is a integrated disease caused by many interacted factors which lead to the turbulence of the glucose, amino acid and the lipid metabolism, due to the lack of insulin hyposecretion or insulin cells metabolism limitation. Its basic characteristic is the abnormal rise of the glucose content in the blood circulation.

糖尿病是多种因素联合作用而导致的胰岛素分泌不足或胰岛细胞代谢的缺陷所引起的葡萄糖、氨基酸及脂质代谢紊乱，以血液循环中葡萄糖浓度异常升高为基本特征的一种综合疾病。

In order to explore the mechanisms of auxin action and metabolism, as well as the changing characteristics of its relative enzymes, IAA content in strawberry fruits with different treatments was determined by HPLC. Content of IAA and the activity of IAO and POD in fruits treated by NPA or TIBA, the inhibitor of auxin transport, were analyzed to investigate the changing characteristics and possible source of auxin, as well as the relation among IAA, POD and IAO. Results were showed as the followings: there had a certain count of IAA in receptacles and achenes, and IAA content in achenes was higher than that in receptacles.

摘要为了探索草莓果实中生长素的代谢变化及其发挥作用的机理，利用HPLC定量测定了草莓果实发育过程中瘦果和花托中的吲哚乙酸，结合生长素运输抑制剂NPA和TIBA处理考察了草莓果实中IAA含量以及不同存在状态的生长素氧化酶和过氧化物酶活性变化，综合分析了草莓果实中IAA 的变化特性、可能来源及其与生长素代谢相关酶的关系。

Significant decrease in the expression of Oatp1 and increase expression in Oatp2 may be the reason of incensement of extrahepatic metabolism of rocuronium.

本研究显示，肝功能障碍时罗库溴铵有明显肝外代谢增强表现，肾脏是罗库溴铵肝外代谢重要器官。

Fibroblast growth factor 21（FGF21）is a novel fatty metabolic regulator. FGF21 mRNA is most abundantly expressed in liver. FGF21 contribute to fat metabolism, as well as ketogenic responses in liver,and it can promote the uptake of glucose, promote insulin secretion, delaying the development of tumors and other function.

成纤维细胞生长因子21（fibroblast growth factor 21，FGF21）是一种主要的脂肪代谢调节因子，主要在肝脏中表达；FGF21有助于肝脏的脂肪代谢以及生酮反应，可以促进脂肪细胞摄取葡萄糖，促进胰岛素分泌，延缓肿瘤的发展等功能。

Studies on the Metabolism of Mitochondria and Sub-mitochondria and the Effect of Laccase on It by Microcalorimetry

首次将微量热用于亚细胞器层次的研究，测定了鲤鱼肝脏线粒体和亚线粒体体外代谢的热谱及其漆树漆酶的影响，并用MTD方程和演化计算技术对它们的代谢热动力学参数进行了全局优化。

Considering the merits of in vivo studies in biotransformation i. e. activation or inactivation, protein-binding such as sex hormone binding protein , toxicokinetics, and more evaluative in hazard identification and risk assessment, we selected a battery of short-term and long-term in vivo studies, including uterotrophic assay in weaning mice and ovariectomized adult mice, an in vivo multiple endpoints assay, and a gestational and lactational exposure assay to identify the estrogenic effects of endosulfan on the offspring.

考虑到体内试验在代谢转化、血浆蛋白如性激素结合蛋白的结合、代谢动力学等方面比体外试验优越，在危害鉴定和危险度评定中更有价值，我们选择了多项体内试验，包括对幼年小鼠和卵巢切除成年小鼠的子宫增殖作用、对成年去势小鼠的体内多终点观察以及大鼠孕期和哺乳期接触对雄性子代生殖系统结构和功能的改变，即去雄性化或雌性化作用等，来验证硫丹的体内雌激素样作用。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。