产生

We also found that apoptosis was induced by terfenadine in human cancer cell by DNA laddering formation. In this study,we demonstrated that p21、p27、BAX and BAD protein were induced,in contrast,Bcl-2 protein was down regulated by treated with terfenadine.

经过琼胶电泳分析Terfenadine会使人类癌细胞产生DNA ladder的特徵，表示细胞发生凋亡，并随著剂量的增加我们发现：p21、p27、Bax、Bad表现量上升，而PARP有被切断的片段产生，Bcl-2、Caspase-3减少，而且p27有被切断的情形产生。

Mechanistically, expression of a molecule known as P-selectin by the platelets was crucial for mediating the platelet-neutrophil interaction, which induced platelets to produce proinflammatory factors such as TXA2. The authors therefore suggest that disrupting the platelet-neutrophil interaction or blocking the proinflammatory factors produced as a result of this interaction might provide new therapeutic targets for the treatment of individuals with ALI.

具体来说，体现在分子水平上就是由血小板产生的血小板蛋白对于调解血小板和中性粒细胞交互影响起着关键作用，它能够诱导血小板产生致炎因素如血栓素A2等，该文作者因此认为，或许破坏血小板与中性粒细胞间的相互作用或者阻断相互作用所产生的致炎因素可以提供一种新的方法用于治疗急性肺损伤。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

objective to study the risk factors on esbl producing strains of k.pneumoniae and e.coli.methods aprospective survey on esbl producing strainsof k.pneumoniae and e.coli for a36-month period.results the resistance rates ofe.coli were:98.08%for ctx,73.08%for amc.the resistance rates of k.pneuˉmonialwere;95.74%for ctx,97.87%for amc.the use rate of third generation cephalosporins was much higher than those of esbls nonproducing strains（p.05）.it induce esbls that3rd generation cephalosporins were used extensive.after strenghtening the antibiotic controls,esbls detection rate has gone down.conclusion the factors of infection of esbl-producing strains were the severity diseases,cellular immunological condition,improper medical manipulations.to prevent esbl-producing strains,reasonable antibiotics usage may be the effective measure.

目的 分析临床大肠埃希菌及肺炎克雷伯菌产esbls的危险因素，并加以控制。方法前瞻性监测产esbls菌的情况，并对感染者进行临床调查。结果产esbls的大肠埃希菌、肺炎克雷伯菌的耐药率头孢噻肟钠为98.08%和95.74%，阿莫西林+棒酸为73.08%和97.87%，产esbls菌感染者头孢第三代的使用率（70.21%）显著高于非产esbls菌感染者（39.47%）（p.05）；第三代头孢的大量使用诱导esbls的产生。通过加强抗感染药物的使用管理esbls检出率开始下降。结论严重的基础病、高龄、机体免疫力低下，长期住院者是esbls菌感染的易感宿主，皮质激素、化疗及介入性疗法是esbls感染的高危因素。滥用抗感染药是产生esbls的重要因素，合理使用抗感染药是防止esbls产生的主要措施。

The primary forms of interest rate risk to which banks are typically exposed are:(1) repricing risk, which arises from timing differences in the maturity and repricing of bank assets, liabilities and off-balance sheet positions;(2) yield curve risk , which arises from changes in the slope and shape of the yield curve;(3) basis risk, which arises from imperfect correlation in the adjustment of the rates earned and paid on different instruments with otherwise similar repricing characteristics; and (4) optionality, which arises from the expressed or implied options imbedded in many bank assets, liabilities and off-balance sheet portfolios.

银行面对的利率风险主要表现为以下几种形式：（1）再定价风险，它产生于银行资产、负债和表外业务的期限不匹配和利率调整的幅度不一致；（2）收益曲线风险，它产生于收益曲线的斜率和形状发生的变化；（3）基本点风险，与再定价风险相似，它主要来自对不同金融工具收取和支付的利率不成比率的变动；（4）选择权，它产生于银行资产、负债、表外业务中存在的或明或暗的选择权。

We studied the jets photoproduction and it's application in testing the perturbative QCD theory, as well as the relations of jets cross section to the parton distribution in photon and proton. The dependence of jets cross section on scales is also discussed both in LO and in NLO corrections.

二。讨论了光生过程中的喷注产生及其对微扰QCD理论的检验，讨论了喷注产生截面对光子，质子中的部分子分布的依赖关系，以及喷注产生截面的标度依赖性。

During the ESR study of the effects of oxLDL on the ESR signal intensity of hydroxyl radicals in collagen (2 μg/ml)-activated platelets, we found that incubation of human platelets with collagen produced a typical four-line hydroxyl radical signal and a long-lived g = 2.005 radical detectable by spin trapper 5,5-dimethyl-1 pyrroline N-oxide.

在研究oxLDL降低由collagen 〈2 μg/ml〉刺激血小板产生的氢氧自由基〈OH●〉的ESR讯号强度的同时，我们发现以DMPO当自由基捕捉剂，collagen除了刺激血小板产生一个四线的典型氢氧自由基之外，还产生一个长半衰期 g = 2.005的自由基。

"The BlackLight Process generates enormous amounts of cheap, non-polluting heat that will replace the thermal power in coal, oil, gas and nuclear power plants that is then converted to electricity," said Randell Mills, Chairman, CEO, and President of BlackLight Power Inc.

不可见光公司主席、首席执行官兼总裁Randell Mills说&利用不可见光的过程是传说中产生大量便宜的、非污染热能并且产生的热能将会代替由煤、石油、天然气及核电厂所产生的热能，然后将其转化为电能。&

It was showed that the growth speed of hypha, sclerotinia production and the pathogenicity of strains had little relation with host and geographical location. The ability of oxalic acid production of strains had positive relation with the pathogenicity. In order to study the nutrition aptness, 8 kinds of culture mediums were tested and the result showed that S.

sclerotinia不同菌株菌丝的生长速度、菌核产量、致病力与其地理来源和寄主来源关系不大，对12个代表菌株的草酸产生能力的测定表明，菌株的草酸产生能力和病菌的致病性基本呈正相关，致病力较强的菌株草酸产生能力较强；采用8种培养基对代表菌株营养条件进行了研究，结果表明核盘菌S。

Furthermore, the study of quantitative protein chip found that rat antibodies against hPolyHb, bPolyHb or pPolyHb only slighty or even did not cross-react with the Hb/PolyHb of other two species.

此外，抗原芯片方法定量检测结果还表明由大鼠产生的相应抗人，牛或猪血红蛋白的抗体大多不产生或产生很弱的抗原抗体交叉结合反应。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷