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RESULTS The results indicated that PCF could significantly increase the viability of thymocytes and enhance the activities of SOD, GSH-Px, CAT in cells. PCF decreased the amounts of ROS and the rate of apoptosis in cells. PCF inhibited the morpholog alteration of the thymocytes irradiated by UVB and maintained the ultrastructure of cells in normal. PCF attenuated UVB caused DNA fragmentation in thymocytes. While combined ERKs inhibitor yielded typical DNA fragmentation, co-treatment of thymocytes with PCF and JNKs and p38 kinase inhibitors completely blocked UVB-induced DNA fragmentation.

结果 PCF能显著提高UVB辐射后小鼠胸腺淋巴细胞的活性;提高胞浆中SOD、GSH-px、CAT的活性,降低ROS含量及细胞凋率;抑制UVB辐射所致的胸腺淋巴细胞凋的形态学改变,维持细胞的正常超微结构;抑制UVB所致的胸腺淋巴细胞DNA片段的出现;预先应用ERK抑制剂使DNA片段增加,给予JNK和P38抑制剂后协同PCF使DNA片段带减少。

The soft-diet feeding has no significant effect on proliferation of cell in cartilage. But, it leads to increased number of apoptotic cell in cartilage. It suggests that decreased masticatory force induced by soft-diet feeding promote the maturation and apoptosis of cell in cartilage.

软食喂养对这一时期大鼠髁突软骨中的细胞增殖活性影响不大,但却使细胞凋的数量增加,提示软食喂养可能加速了髁突软骨中细胞的分化、成熟、凋,进而影响髁突的正常发育。

Objective:Studies the East Asian pliers scorpion poisonous weakly to perish in vitro induction acute early young granule leukemia cell line HL-60 and to suppress its growth the function.

东亚钳蝎毒诱导白血病细胞HL-60凋的实验研究目的:研究东亚钳蝎毒在体外诱导急性早幼粒白血病细胞株HL-60凋并抑制其生长的作用。

Objective To explore vpr gene of human immunodeficiency virus type 1 (HIV-1 vpr)'s ability to induce cell G2 arrest and apoptosis, and the influence when it mutated, the relationship between Vpr-induced G2 arrest and apoptosis inductions.

目的 研究带有不同变异位点的艾滋病病毒1型(HIV-1)vpr基因,对感染细胞周期和凋的影响,以及其致细胞周期变化和致细胞凋的机制两者间的可能关系。

Our study shows that Bax ,the protein of accelerating apoptosis, may participate in the proliferation and regression of hemangioma. 2 The expression of TGFβ1 in the involuting phase was higher than in the proliferative phase, the difference was statistically significant, p<0.01. 3 This shows that Bax and TGFβ1 may be the important factors which cause the apoptosis of hemangioma and accelerate its regression as well.

1 Bax在血管瘤增生晚期开始表达,至退化期Bax的表达达到高峰,提示Bax这种促进细胞凋的蛋白参与血管瘤的增生与退化过程。2 TGFβ1在血管瘤退化期的表达高于增生期,差异有统计学意义,p<0.01.3 提示Bax与TGFβ1可能是引起血管瘤凋,进而促进其退化的重要因素。

Results: When incubated with different concentrations mitomycin for 24 hours, the body cells from 40μmol/L to 70μmol/L showed apoptosis under transmission electron microscope, chromatin condensation, even nuclear fragmentation, to form the apoptosis body can be seen.

体细胞经不同浓度的药物处理24h后,透射电镜下发现在40μmol/L~70μmol/L的各组细胞均有凋细胞,细胞核固缩、凝聚,甚至断裂,形成凋小体。

Methods: Male Sprague-Dawley rats were subjected to lateral fluid percussion brain injury of moderate severity. bax and bcl-xL mRNA and protein expression was detected by RT-PCR an d immunohistochemistry. In addition to morphological evidence of apoptosis, TUNE L histochemistry was used to identify DNA fragmentation in situ under both l ight and electron microscope, whereas characteristic internucleosomal DN A fragm entation of apoptosis was demonstrated by DNA gel electrophoresis.

在液压脑损伤模型中,应用逆转录聚合酶链反应、免疫组化分别检测大鼠脑创伤后不同时程bax和bcl-xL表达;采用凋原位末端标记、电镜超微结构、DNA凝胶电泳观察脑创伤后细胞凋的形态和生化特征。

Lens epithelial cell apoptosis: There were no apoptotic cells in the control group within 72 hours.

晶状体上皮细胞凋情况:对照组在培养的72 h内一直未见有凋细胞。

PartⅡExperimental Study on Acute Hypatocyte Necrosis and Apoptosis with MRI, DWI and MRS Objective: To demonstrate the ability and value of MR imaging, diffusion-weighted imaging, and MR spectroscopy in detecting and characterizing necrosis and apoptosis in vivo with a comparison to the pathology after establishment of hepatic necrosis and apoptosis animal model by different surgical ligations of hepatic blood supply vessels.

目的:通过手术结扎的方法建立大鼠肝细胞坏死和凋的动物模型,将不同时间点的MRI、DWI和MRS检测结果与病理学所见进行对照研究,以评价MRI、DWI及MRS在检测及鉴别肝细胞凋和坏死两种病理改变的能力与价值。

Study aiming at regulation as well as prevention and cure of cell apoptosis is the hot spot in topics of myocardial protection because cell apoptosis is one of important mechanism in MIRI.

现就对细胞凋与MIRI的关系以及细胞凋的途径、调控因素和防治的研究进展作一综述。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。