亡

Methods: The expression of apoptosis and the positive expression of p53, bcl－ 2 proteins were observed in 31 cases of breast cancer in situs, 20 breast dysplasia and 20 breast hyperplasia by using DNA nick end labeling technique and immunohistochemical staining .

目的：通过观察乳腺癌及其癌前病变中细胞凋亡和凋亡调控基因p53、bcl－2的表达，探讨细胞凋亡与凋亡调控基因在乳腺组织恶性转化进程中的作用。

The results showed that both CDV strains could induce apoptosis of infected cells. However, there was significant difference in the percentage of apoptotic cells between the two strains (P＜0.01). The strain resulted in the CPE type of cell-rounding induced much higher ratio of apoptotic cells than the strain resulted in the CPE type of syncytium.

结果发现，2种毒株感染引起的细胞病变类型不同，分为圆缩型与合胞体型；2种毒株均可诱导感染细胞凋亡，但毒株间的凋亡细胞比例存在差异，即产生合胞体型细胞病变的毒株凋亡出现较晚，凋亡细胞比例显著低于产生圆缩型细胞病变的毒株(P＜0.01)。

The lost of microvilli, membrane convolution and vacuolation in plasma were common.

用ISEL特异标记凋亡细胞，显示了凋亡细胞的形态学特点和凋亡小体的清除过程，从形态学上证实诱导凋亡是射线损伤造血细胞的途径之一。

The rates of apoptotic granulosa cells in all kinds of follicles in immature gilts were ashigh as atretic follicles;it decreased significantly after injection of PMSG,but it was higherand lasted shorter than that of mature pig.

性未成熟仔母猪卵巢中各类卵泡颗粒细胞凋亡比例很高，接近闭锁卵泡的凋亡比例；注射PMSG后则各类卵泡颗粒细胞凋亡比例显著下降，但高于性成熟母猪注射PMSG后的凋亡比例，并且维持的时间也较短。

Figure 6 Bright fluorescence of condensed nuclear chromatin appeared around circumnuclear edge of apoptotic osteoclast,nonapoptotic nuclear fluorescence showed coherent distributed.

凋亡细胞核核周呈一亮环，而未凋亡细胞核染色均一（图6）。图6 凋亡破骨细胞胞核周缘呈环状亮色，而未凋亡细胞核荧光染色均一。

It is proposed that coadministration of carbachol could prevent apoptosis and related alterations in gene expressions induced by sodium selenite just as the carbachol did in the case when apoptosis and related changes in genomic expression were induced by β-amyloid peptide. The facts suggest that apoptosis, at least that induced by two agents tested by us, might be initiated through a similar pathway.

这些结果表明，亚硒酸钠能在较早的时间诱导培养的大脑皮质神经元凋亡，且具有明显的剂量和时间依赖关系；凋亡的引起可能是以亚硒酸钠影响某些特殊基因的表达为基础，其中，c-fos、bax、P53、和bcl-表达的变化主要与细胞凋亡的早期事件有关，而AChE基因表达的增强同凋亡发展的整个过程密切相关。

In addition, a metabolic inhibitor, actinomycin D has no effect on enzymatic activities of caspase-1/ICE-like and caspase-3/CPP-32/like proteases during Fas-mediated CD4〓T cell apoptosis. These results indicate that the appearance of caspase-1/ICE-like and caspase-3/CPP32-1ike proteases activities is a post-translational activation of these proteases. It is likely these caspases constituently express in a inactive form in the cytosol of CD4〓T lymphocytes. Once the rest SEB-responsive CD4〓T cells are restimulted, those inactive caspases such as caspase-1/ICE-like and caspase-3/CPP32-1ike proteases are sequentially cleaved to become active forms, and the apoptotic signal is transducted to downstream signaling molecules, Finally leads to CD4〓T cells apoptosis.

另外，通过代谢抑制剂放线菌素D对超抗原SEB诱导静息SEB应答〓细胞凋亡过程中Caspase成员酶活性变化的研究表明Caspase-1／ICE样，Caspase-3／CPP32样胱氨蛋白酶并非新合成的信号分子，很可能以无活性方式组成性表达于静息SEB应答〓细胞胞浆，在超抗原SEB再次刺激诱导〓细胞凋亡早期，先后顺序活化，借以传递凋亡信号到下游信号分子，诱导〓细胞凋亡。

In TUNEL assay it can be observed that cystamine can reduce myocardial cell apoptosis . At the same time Western Blot analysis to prove cystamine can reduce cardiac cell apoptosis and Deth receptor and Mitochondria through theses two pathsway, NF-κB protein expression significantly increased furthermore, it promots cell survival, which can reduce cardiac hypertrophy,apoptosis.

在TUNEL assay中可以观察到胱胺可以减少心肌细胞的凋亡，同时我们也利用Western Blot证明胱胺可以减少心肌细胞的凋亡是透过Deth receptor和Mitochondria这两条路径，而这样子降低凋亡的现象很有可能与NF-kB这讯息传递的分子上升有关，因此胱胺确实具有保护心肌细胞的作用，可改善心肌细胞肥大、凋亡的情形。

Part II Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cellsTo study the Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cells.

第二部分藤黄酸对淋系肿瘤细胞系的细胞凋亡及抗凋亡蛋白的调控作用研究藤黄酸对人急性T淋巴细胞白血病细胞株Jurkat细胞和人Burkitt淋巴瘤细胞株Raji细胞的诱导凋亡及抗凋亡蛋白的调控作用。

Under transmission electron microscope, there were many reactions such as apoptosis with apoptotic index of (43.34 ± 18.27)% and karyopyknosis in titanium alloy porcelain-fused-to-metal.

钛合金修复体组电镜下可见细胞凋亡，凋亡指数(43.34±18.27)%，有细胞核固缩等反应；金铂合金修复体组细胞凋亡很少，凋亡指数(26.90±17.35)%。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。