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Objective To study cfos expression and apoptosis after traumatic brain injury in rats,and to explore the role of apoptosis in the secondary brain injury,and the relation between cfos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织cfos表达及神经细胞凋,探讨神经细胞凋在脑继发性损害中的作用,及cfos基因表达与凋的关系。

Objective To study c fos expression and apoptosis after traumatic brain injury in rats,and to explore the role of apoptosis in the secondary brain injury,and the relation between c fos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织c fos表达及神经细胞凋,探讨神经细胞凋在脑继发性损害中的作用,及c fos基因表达与凋的关系。

objective To study cfos expression and apoptosis after traumatic brain injury in ratsand to explore the role of apoptosis in the secondary brain injuryand the relation between cfos expression and neuroglial apoptosis.

目的 研究创伤性脑损伤后脑组织cfos表达及神经细胞凋,探讨神经细胞凋在脑继发性损害中的作用,及cfos基因表达与凋的关系。

Result Compared to concurrent control groups, neuromotor function are significantly improved in 1h and 6h experiment group. The indexes of neural cell apoptosis decreased significantly (P 0.01). But in 24h experiment group, the decrease of the index are not statistically significant. Conclusion Early application of rhEPO could lessen the lesion of neuromotor function. The protection is partially due to the reduction of neural cell apoptosis.

结果:与对照组相比,脊髓损伤后促红细胞生成素1小时,6小时实验组神经运动功能明显改善,脊髓神经细胞凋指数均明显下降(P 0.01);而术后24小时组与对照组相比,脊髓神经细胞凋指数的下降无统计学意义结论:早期应用外源性EPO对脊髓不完全损伤后引起的神经运动功能损害具有保护作用,此种保护作用可能与EPO能够减少神经细胞凋有关。

To 26. 23, P <0. 01.CONCLUSION: Chlamys farreri is capable of increasing Bcl-2 protein and decreasing Bax protein in cerebral penumbra to brake the initiation of neuron apoptosis after ischemia-reperfusion and preserve neuronic function in penumbra.

扇贝多肽能够上调脑缺血半影区内抑制神经细胞凋的Bcl-2蛋白水平,同时降低半影区内诱导神经细胞凋的Bax蛋白的表达,从而在阻止脑缺血再灌注后细胞凋启动中起制动作用,保护脑缺血后半影区内神经元的功能。

Based on these results and inferred to related reports from other labratories, it was possible to make some analyses and conclusions or inferrences:(1) CD〓AK with tumoricidal activity were induced and expanded in number througth costimulation of PBMC with anti-CD〓 McAb . and r IL-2 ;(2) CD〓AK induced and expanded in such manner did exibit more potent proliferation·ability and cytotoxicity which maintained for lonser time than those of LAK cells, thus CD〓AK was a new variety of antitumor effector cells worth to be explored;(3) CD〓AK could mediate MHC nonrestricted cytotoxicity and kill tumor target cells through inducing necrosis and apoptosis;(4) Normal mature lymphocytes of PBMC could be induced to proliferate and /or to die from apoptosis when they were costimulated by anti-CD〓McAb and rIL-2. Both proliferation and apoptosis were existing in the same cultivation system sugsesting that the presence of rIL- 2 might provide some accessary signals for apoptosis.

以这些结果为基础并参考其它有关文献可能做出如下分析与结论或推论:(1)用抗CD〓单抗和rIL-2共刺激外周血单个核细胞能诱生扩增出具有杀瘤活性的CD〓AK细胞,(2)与LAK相比,用这种方法诱生扩增的CD〓AK增殖能力强、细胞毒活性强而且维持时间长;CD〓AK是一类值得开发的抗瘤效应细胞;(3)CD〓AK能够介导MHC非限制性细胞毒活性,可以通过诱导靶细胞坏死和/或凋杀伤肿瘤细胞;(4)正常外周血单个核细胞中的成熟淋巴细胞在受到抗CD〓单抗和rIL-2共同刺激后既可诱导增殖也可诱导凋,两者并存于同一体系,推测rIL-2的存在可能为细胞凋提供一些辅助信号。

This article reviews about relationship of Tumor with Mechanism of Cell Oncosis.

本文就细胞胀的发生机制及其与肿瘤的关系予以综述。关键词:胀;凋;肿瘤

Oncosis is different from apoptosis in morphologic,mechanism and the role in cardiovascular diseases.

在形态学及其发生机制上与凋不同,并且在心血管疾病中所扮演的角色也与凋有明显差别。

The study of cellular oncosis is still at the primary phase, and people lack efficient method to identify the oncosis and unreveal the pathology significance of oncosis in cardiovascular diseases.

尽管目前尚缺乏鉴别细胞胀的有效方法,限制了细胞胀在心血管疾病中病理意义的揭示,但通过信号通路研究,有望找到细胞胀的标志性蛋白;有利于心血管疾病防治建立崭新的靶点。

Oncosis is a special mode of non-apoptotic cell death,it is characterized by cellswelling,budding,organelle swelling,increased cellmembrane permeability and caryolysis.

是一种特殊形式的非凋性细胞死方式,它的特征性表现为细胞肿胀、起泡、细胞器肿胀、细胞膜通透性增加和核溶解。胀理论的提出为临床医学的发展提供了良好的机遇和理论指导。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。