亚萘基

A series of diazonium salts of 4-(N-methyl-N-phenylamino)-3-amino-1,8-naphthalic anhydride 5a, its naphthalimide derivative 5b, and 5e were designed and synthesized,and it was the first time to discover that aromatic radical-induced intramolecular aromatic 1, 5-hydrogen transfer was also involved in the nitrogen-contianed system during Pschorr cyclization.

实验设计合成了4--3-氨基-1，8-萘酐的重氮盐5a、其衍生物N-丁基-4--3-氨基-1，8-萘酰亚胺的重氮盐5b和N--4--3-氨基-1，8-萘酰亚胺的重氮盐5c，并首次发现了通过普朔尔环化反应以氮甲基化的氮为桥原子的体系存在着芳香自由基诱导的芳香1，5-氢转移。

In HCl medium, iodate oxidizes hydroxylammonium chloride to form nitrite, which can produce a red azo dye with the reaction of p nitroaniline and α naphthylamine.

基于碘酸根在稀盐酸介质中氧化盐酸羟胺产生亚硝酸根，而亚硝酸根和对硝基苯胺重氮化后可以与α-萘胺偶联产生红色偶氮染料，提出了分光光度法测定碘的新方法。

A series of 3-naphthyl-2--1,3-thiazolidin-4-ones were synthesized by the three-component one-pot cyclocondensation of naphthylamine, aromatic aldehyde and 2-mercaptoacetic acid using a microwave-assisted method in the presence of DMAP/DCC.

利用微波促进的多组分一锅法，在封管条件下，以萘胺、芳醛和巯基乙酸为原料，4-二甲氨基吡啶/N，N'-二环已基碳二亚胺为催化剂，合成了系列新的噻唑烷酮衍生物，该反应具有时间短、操作简便等优点。

The Study on the Synthesis and Properties of Quinoline Derivatives Containing 1, 8-naphthalimide Unit

含1，8-萘酰亚胺基元的喹啉类衍生物的合成及其性质研究

In order to obtained the six-membered ring compound and a thorough assignment of the spectra, and further to prove that the six-membered ring compound was formed from the hydrogen transfer, the compound N-butyl-4-(N-methylphenylamino)-5-amino- 1, 8-naphthalimide 6 was designed to obtained with N-butyl-4-bromo-5-amino-1, 8-naphthalimide and N-methyl phenylamine as the starting material. However it was difficult to obtain the desired product as the different solvent giving the different products except the desired product.

为了能够得到六元环化合物作为定标的物质及其确切的谱图分析结果，并且为了进一步证明由五元环产物通过氢转移得到六元环产物的正确性，设计用N-丁基4-溴-5-氨基-1，8-萘酰亚胺与N-甲基苯胺反应生成N-丁基-4--5-氨基-1，8-萘酰亚胺6，结果发现这种方法很难实现，选择不同的溶剂会生成不同的产物，却都不是目标产物。

Results: Myricetin and quercetin other than kaempferol showed the inhibitory effects against p110β PI3K, and their IC50 was 2.93μmol/L and 9.91μmol/L, respectively.

结果：杨梅素和榭槲皮素对重组人PI3K p110β催化亚基有抑制作用，IC50分别为2.93μmol/L和9.91μmol/L，而山萘黄素对PI3K p110β催化亚基则无抑制作用。

Reactions of 2-methyl-1,4 naphthoquinone with human telomeric DNA and telomerase RNA ESR spin elimination has been used with 4-oxo-TEMPO as spin trap. The reactivities of 3VK3* with telomeric DNA, template of telomerase RNA and its L6-P6 region have been confirmed respectively. The results show that the reactivity of 3VK3* with polynucleotides is directly proportional to their G amount, and the one for reaction of 3VK3* with telomeric DNA is the highest in polynucleotides. 2. Reactions of 2-methyl-1,4 naphthoquinone with nucleosides, nucleotides ESR spin elimination has been used with 4-oxo-TEMPO as spin trap.

2-甲基-1，4萘醌与端粒DNA及端粒酶RNA亚基光敏反应性的研究应用ESR自旋消减法，对2-甲基-1，4萘醌(VK3)与端粒DNA重复序列、端粒酶RNA亚基模版序列、端粒酶RNA亚基L6-P6发夹区关键序列的光敏反应性进行了研究，结果表明，在一定波长照射下，明显诱导VK3与上述寡聚核苷酸反应，其反应性大小与核酸中鸟嘌呤含量正相关，其中端粒DNA序列反应性最强。

New reactions found in this program include: photoinduced regioselective free radical addition to aromatic imines;photoinduced Dielse-Alder reactions of aromatic imines for synthesis of tetrahydroquinoline derivatives;Photoinduced radical cation mediated selective ring opening reaction of epoxides;Formation of novel macrocyclic crown ethers by photoinduced reaction of diazonaphthaquinones;photoinduced selective desilylation of silyl ethers.

用这种方法成功的发现了下列在有机合成中有意义的新反应：(1)光诱导产生的自由基正离子诱导的自由基对芳香亚胺的区域选择性加成反应；(2)用光诱导的芳香亚胺的Diels-Alder反应合成四氢喹啉衍生物；(3)经光诱导产生的自由基正离子基诱导的环氧化物选择性开环反应；（4）重氮萘酮在环醚中经光诱导反应形成新奇的大环冠醚；（5）硅醚的光诱导选择性脱硅基反应。

Cold crystallization process of N-(1-naphthyl) succinimide below glass transition temperature was monitored by differential scanning calorimetry and X-ray diffraction.

采用x射线粉末衍射和差示扫描量热分析方法，跟踪研究了N-（1-萘基）琥珀酰亚胺的液氮淬冷样品在室温(25℃)即在玻璃化转变温度以下的冷结晶行为。

The ten target compounds from alkyl substituent to aryl substituent that have not yet been reported,which was obtained by dehydration, Subsequently treated with sodium nitrite resulting nitroso compounds and then reduced.

本论文以2-羟基-3-萘酸和邻巯基苯胺为原料，通过分子脱水、亚硝化、还原等反应合成了10个不同取代基团的4-苯并噻唑基-[1，2-d]萘并噁唑衍生物，并优化了合成的工艺条件。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。