亚硝基化

It can greatly promote carcinogenesis. DNA diluted alkali firer proves N-nitroso compounds induce the crosslinking between complementary DNA base pairs and initiate cell cancerization.

DNA城稀释过滤法证明，N-亚硝基化合物含氮杂环化借诱发DNA互补碱对之间的交联而启动细胞的癌变。

Despite its importance, the study of S-nitrosylation remains methodologically challenges because of the lability of S-NO bond and low-abundant level of endogenously S-nitrosylated proteins.

尽管此调控具有重要性，由於硫基亚硝基键结的不稳定及低含量的内生性硫基亚硝基化蛋白质，导致在研究蛋白质硫基亚硝基化的方法上面临许多挑战。

In HCl medium, iodate oxidizes hydroxylammonium chloride to form nitrite, which can produce a red azo dye with the reaction of p nitroaniline and α naphthylamine.

基于碘酸根在稀盐酸介质中氧化盐酸羟胺产生亚硝酸根，而亚硝酸根和对硝基苯胺重氮化后可以与α-萘胺偶联产生红色偶氮染料，提出了分光光度法测定碘的新方法。

Besides,through Arbuzov reaction,Vilsmer-Haack Hydroformylation,Wittig-Horner reaction,nitryl hydrogenation deoxidize,and imidization five steps synthesized another compound which included hole-transporting,electron-transporting and luminescence materials.

此外，又通过Arbuzov反应、Vilsmer-Haack甲酰化反应、Wittig-Horner反应生成二苯乙烯、硝基加氢还原、酰亚胺化5步反应合成了一种集空穴传输-电子传输-发射三位一体的新型苝酰亚胺化合物。

Furthermore, through molecular structural design, we have also synthesized stable dual functional diphenylether polymer intermediates of ABB' types possessing ortho-dicarboxylic at one aromatic ring and diamine groups at another beginning from Xylenol and 1-Chloro-3,4-dinitrobenzene as the raw materials.

中文摘要本研究应用自氧化法与氢化法两反应，成功而有劾地制备出芳香族含酸酐及二胺基之官能基单体，并进一步经由分子结构设计，从3，4-二甲苯酚及1-氯-3，4-二硝基苯为原料，转化合成出安定性高带有羧基与双胺基双官能基之堑新ABB'型二苯醚中间体，并成功地应用此中间体从事自聚合反应，而合成分歧状聚醚亚醯胺高分子。

The synthetic route starts from penicillin G, peroxyacetic acid(8.5%) as Oxidizing Agent to get penicillin G sulfoxide; esterifided with p-nitrobenzyl bromine to synthesize penicillin G sulfoxide ester; we synthesize 3-exomethylenecepham sulfoxide ester with phthalimide potassium and 4A molecular sieve as acid scavenger to open the ring, SnCl_4 as catalyzation to close the ring. The yield is over 60%.

本研究采用的合成路线为：以青霉素G钾盐为原料，选用工业过氧化氢制备的过氧乙酸(22.3%)稀释至8.5%为氧化剂，氧化得青霉素亚砜；采用对硝基溴苄为酯化试剂，制备青霉素亚砜酯；以NCP(N-氯代邻苯二甲酰亚胺)为开环试剂，酞酰亚胺钾和4A型分子筛为酸清除剂，顺利开环；再经无水SnCl_4催化闭环得3-环外亚甲基头孢亚砜酯，最终产率在60%以上。

Methods: 2ethyl aniline was used as starting material of the synthesis and was processed by acetic anhydride acylation, strong nitric acid nitraction at low temperature, and desacyl synthesis to produce 2ethyl5nitro aniline. The product was then synthesized to 3methyl6nitro1Hindazole by using ringclosing reaction in the presence of NaNO2, and then ethylated to obtain 2,3diethyl6 nitro2Hindazole. The latter compound was then reduced by SnCl2/Hcl to get target compound 2,3diethyl6nitro2Hindazole.

以2乙基苯胺为原料经醋酐酰化、浓硝酸低温硝化及去酰基保护合成2乙基5硝基苯胺，后用亚硝酸钠关环得3甲基6硝基1H吲唑，经硫酸二甲酯甲基化得2，3二甲基6硝基2H吲唑，最后用氯化亚锡将其还原得到目标产物，通过1H NMR确定结构与目标产物一致。

Methods: 2-ethyl aniline was used as starting material of the synthesis and was processed by acetic anhydride acylation, strong nitric acid nitraction at low temperature, and desacyl synthesis to produce 2-ethyl-5-nitro aniline. The product was then synthesized to 3-methyl-6-nitro-lH-indazole by using ring-closing reaction in the presence of NaNO2, and then ethylated to obtain 2, 3-diethyl-6- nitro-2H-indazole. The latter compound was then reduced by SnC12/Hcl to get target compound 2, 3-diethyl-6-nitro-2H-indazole.

以2-乙基苯胺为原料经醋酐酰化、浓硝酸低温硝化及去酰基保护合成2-乙基－5-硝基苯胺，后用亚硝酸钠关环得3-甲基－6-硝基－1H-吲唑，经硫酸二甲酯甲基化得2，3-二甲基－6-硝基－2H-吲唑，最后用氯化亚锡将其还原得到目标产物，通过1HNMR确定结构与目标产物一致。

These facts showed that there exists a typical nitrosation reaction, because the reduction peaks in the I-V curves of green product and its acidified solution could be ascribed to typical nitroso aromatic compound.

因此，这一显色反应可认为是一典型的亚硝基化反应。

In an acetate buffer of pH 6.0,and in the presence of CTMAB,a stable complex,having the mole ratio of 1 to 3,was formed between cobalt ion and nitroso R salt,which was concentrated on C18 solid phase extraction column,achieving a concentration multiplication of 100 times.

研究了用亚硝基R盐离子对固相萃取光度法测定钴，在pH 6.0的HOAc-NH4OAc缓冲介质中，溴化十六烷基三甲基铵存在下，亚硝基R盐与钴反应生成3∶1稳定络合物，该络合物可用C18固相萃取小柱富集，富集倍数达100倍，小柱上富集的络合物用乙醇洗脱后用光度法测定，钴的质量浓度在0.05~5.0 mg.L-1内符合比耳定律。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。