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Methods Activate GAMP with cyanogens bromide and prepare GAMP-protein conjugates using ADH as a linker and EDAC as a coupling agent.

方法采用溴化氰活化多糖,以无水己二酸二肼为连接剂,1-乙基-1-3-(3-二甲基氨基-丙基)-碳化二亚胺为偶联剂,制备结合物并免疫小鼠,检测小鼠血清中抗GAMP与抗载体蛋白抗体及抗GAMP抗体的杀菌活性。

Methods Activate GAMP with cyanogens bromide and prepare GAMP-protein conjugates using ADH as a linker and EDAC as a coupling agent. Immunize mice with the conjugates and determine the antibodies against GAMP and carrier proteins in their sera as well as the bactericidal activity of antibody against GAMP.

采用溴化氰活化多糖,以无水己二酸二肼为连接剂,1-乙基-1-3-(3-二甲基氨基-丙基)-碳化二亚胺为偶联剂,制备结合物并免疫小鼠,检测小鼠血清中抗GAMP与抗载体蛋白抗体及抗GAMP抗体的杀菌活性。

In addition to the lithium salts, we have also synthesized and studied the other types of ionic liquids, in which N-methyl-N-propyl piperidinium bis imide (PP13-TFSI) shows a wider electrochemical window -0.3 ~ 5.6 V vs.

在实践中对项目研究作了部分调整,另外也合成和研究了其它类型的离子液体,其中N-甲基-N-丙基哌啶三氟甲基磺酰亚胺(PP13-TFSI)表现出更宽的电化学稳定窗口-0.3 ~ 5.6 V vs。

Based on orthogonal test, the factors influencing the synthesis of di-n-propyl phosphite, such as reaction temperature, reaction time and molar ratio of reactant, were investigated.

通过正交优化试验,考察了温度、时间和物料配比对二正丙基亚磷酸酯的合成收率的影响。

Via comprehensive computations, the possibilities of vinylidene and allene intermediates were excluded, and the reaction mechanism was found to contain the following three steps:(1) gold-catalyzed cyclization to give the cyclic intermediate,(2) the cyclic intermediate undergoing a 1,3-H migration to give a more stable intermediate, with the assistance of water-cluster,(3) finially, the 1,2-H or 1,2-silyl migration occuring for generation of the observed product.

通过对各种可能的反应路径的进行计算和比较,排除了亚甲基卡宾和连二烯中间体的可能性,并确定该异构化反应机理包含以下三个步骤:(1)炔丙基吡啶反应在金催化条件下发生分子内的成环得到环状中间体;(2)环状中间体在水分子簇的协助下优先发生1,3-氢迁移反应,异构化得到更为稳定的中间体;(3)最后再进行1,2-氢迁移或是1,2-硅烷基团迁移即得到实验中所观察到的环异构化产物。

Although these inhibitors including 19 compounds of benzylidene malononitrile family and 13 compounds of 3-substituted indolin-2-ones family, possess quite different structures,a common pharmacophore model with very good stratistical results was determined.

尽管亚苄基丙二腈化合物和3-取代吲哚啉-2-酮系列化合物具有完全不同的骨架结构,但得到的药效团却具有共同的特性,这表明当这两类抑制剂和受体发生相互作用时,采用了相似的结合模式。

Lignin based polyurethane films were prepared by solution casting from hydroxypropyl lignin derivatives and hexamethylene diisocyanate or toluene diisocyanate.

以羟丙基化木素和甲苯二异氰酸酯或六亚甲基二异氰酸酯为原料,采用溶液流延法制备了聚氨酯。

Thiobarbituric acid was synthesized by sulfourea and diethyl malonate in sodium alcohol and 5-Arylidene thiobarbituric acid was prepared by the Knoevenagel condensation reaction from benzaldehyde and thiobarbituric acid.

采用丙二酸二乙酯和硫脲在乙醇钠存在下合成了硫代巴比妥酸,再分别采用固相反应和水相反应,由硫代巴比妥酸和苯甲醛经Knoevenagel缩合反应,制备了5-亚苄基硫代巴比妥酸。

Among the special nine pollutants, however, eight of them, including Hexachlorobenzene, N-Nitrosodi-N-propylamine, 3,3-dichlorobenzidine, 2,4,6-trichlorophenol, 2,3,4,5,6-pentachlorophenol, indeno (1,2,3-cd) pyrene, 4,4'-DDT and Heptachlor were in need of concern while another chemical: dibenzanthracene be of special concern. The sources of these chemicals were discussed and some control strategies were suggested based on the risk assessment.

结果表明,有18种有机污染物超过了USEPA的标准浓度要求,其中9种物质具有一定的生态风险,其中六氯苯、N-亚硝基二正丙胺、3,3'-二氯联苯胺、2,4,6-三氯酚、五氯酚、茚并(1,2,3-cd)芘、4,4'-滴滴涕、七氯在内的8种化合物具有一定的风险,而多环芳烃二苯并蒽需要引起更高警惕;在此基础上探讨了这些化合物的来源及作用,并提出了相应的防治建议。

Copper iodide CuI has a apparent inhibition effect on addition rearrange of the Grignard reagent with carbonyl compounds.

为抑制烯丙基格氏试剂与羰基化合物加成反应中的重排反应,进行了碘化亚铜CuI对此类格氏试剂及加成产物组分比例关系的研究,CuI对这类化合物加成反应重排有明显的抑制作用。

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