二聚

To study the expression, purification and bioactivity of human augmenter of liver regeneration in Pichia Pastoris, the expression plasmid pPICZαA- ALR was constructed and transformed into P. Pastoris by the method of electroporation transformation. Induced with 0.5% methanol, the 30 kD protein in the culture supernatant of recombinant P. Pastoris was confirmed to be rhALR by SDS-PAGE and Western blot. Quantitative analysis showed that the target protein was in a level of 66% of the total protein of the culture supernatant, with a yield of 40mg/L.we had performed DEAE anion exchange chromatography two times with excessive and regular adsorption quantity consecutively, and then the rhALR above 95% purity and 52% protein recovery could be obtained by G75 molecular sieve chromatography at last step. The bioactivity assay of the purified product showed that rhALR could stimulate the proliferation of HepG2, SMMC-7721 and NIH-3T3 in vitro.

为在毕赤酵母中分泌表达人肝再生增强因子，以色谱法分离纯化后进行体外活性研究，构建表达载体pPICZαA- ALR，经电穿孔转入毕赤酵母中，用0.5％甲醇诱导表达；重组酵母培养上清经SDS-PAGE电泳和western blot鉴定后表明， rhALR以分子量为30kD的二聚体为主；定量分析结果表明，重组酵母培养上清中rhALR约占总蛋白的66％，表达量约为40mg/L；经DEAE柱和G75柱纯化后，获得的rhALR纯度大于95％，得率为52％；体外生物学活性实验表明，rhALR能明显促进HepG2、SMMC-7721和NIH-3T3细胞的增殖。

"The ability to use the D-dimer test as an aid in the diagnosis of VTE, DVT, or PE provides another significant offering to hospital laboratories worldwide," said Jim Reid-Anderson, chairman, president, and CEO of Dade Behring, which developed the test.

"使用D-二聚体检测来诊断VTE、DVT或者PE，为世界范围内的实验室提供了另外一项重要方法，"Jim Reid-Anderson说，他是Dade Behring公司主席、总裁兼首席执行官，正是该公司研发了这种检测方法。

CRP/CAP Catabolite activator protein,CAP is an activator required for high level transcription of the lac operon.The active molecule is a CRP dimer that binds 3'5' cyclic AMP to form a CRP-cAMP complex.

CRP/CAP 分解代谢物激活蛋白CAP是Lac操纵子高水平转录的一个必须的激活因子，有活性的CRP二聚体与3ˊ5ˊ-环式AMP结合形成CRP-cAMP复合物。

Human Hp 1-1, cervine Hp, and porcine Hp is homogeneous dimer2, tetramer4, and dimer ????

人类Hp 1-1、鹿Hp以及猪Hp在型态上个别为同质性二聚体？？？？

By measuring changes of Plasma levels of GMP-140, GP lib/III a and D-dimer in patients with OSAS before and after the institution of nasal continuous positive airway pressure, we want to study whether plate activation and enhance coagulability, fibrinolytic activation occur and play a role in prevalence ofcerebrovascular and cardiovascular events in patients with OSAS and the association with hypoxemia, if so, whether therapy with nCPAP alters this effect.

我们通过检测OSAS患者血浆α-颗粒膜蛋白(GMP-140)、血小板膜糖蛋白Ⅱb／Ⅲa和D-二聚体的变化，了解OSAS患者体内是否也存在血小板活化、凝血激活和继发纤溶亢进及其与低氧血症的关系，进一步从分子生物学角度探讨血小板活化、凝血激活和继发纤溶亢进在OSAS发生发展中的作用及经鼻持续气道正压通气对其影响。

Serum PT, APTT, Fib, and D-dimer were measured with an automatic coagulometer on d 0, 3, 7, 14 when YH16 was used.

YH16使用前1d及使用后3、7、14d空腹采集外周静脉血，用全自动血凝仪检测凝血酶原时间、纤维蛋白原、部分凝血活酶时间、凝血酶时间和D二聚体。

The recognition mechanisms of GGR and TCR to UVB-induced photodamages were summarized: Xeroderma Pigmentosum group C, the recognition factor in GGR, executed its function avoiding direct contacting with lesions; the conversion between monomer and dimer of Cockayne syndrome B protein was underlined in the recognition of TCR; ubiquitylation mediated by DNA damage binding protein played an important role in NER recognization at chromatin level; moreover, the fate of the recognition factors was also discussed.

识别因子XPC通过一种不直接识别损伤本身的机制在GGR识别过程中发挥作用；在TCR识别过程中强调了关键因子CSB单体及二聚体两种形式的转换。在染色质水平上，DDB介导的泛素化作用是NER识别过程中重要的调控要素。另外，完成使命的识别因子的最终走向也是NER途径中的一个重要环节。通过分析上述生化过程，较清楚地总结了GGR及TCR对UVB导致的光损伤的识别机制。

Data Analysis: Assuming a 0% event rate in patients with D-dimer levels between 200 and 500 ng/mL, a sample of 450 patients would result in a 95% confidence interval upper limit of 0.6%.

数据分析：假设D-二聚体水平在200~500ng/ml之间的患者概率事件为0%，则450例患者的样本产生的95%可信区间上限为0.6%。

Objective: To study the clinical significance of D-dimer judging the thrombosis of coronary artery in acute coronary syndrome patients.

目的：探讨D-二聚体定量检测对于判定急性冠脉综合征血栓形成的意义。

Test the content of D-dimer is a comparative distinctive, sensitive marker in judgement thrombosis of coronary artery.

D-二聚体定量检测是判定ACS血栓形成相对特异的敏感指标。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。