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二羧酸

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We examined the effects and mechanisms of methyl pentyl 1,4-dihydro-2,6-dimethyl-4-(3-notrophenyl)-3,5-pyridinedicarboxylate (Mn9202), a novel DHPs calcium antagonist and lacidipine on the 5-HT2B receptor in cultured rat stomach fundus smooth muscle cells.

本研究以富含5-HT_(2B)受体的大鼠胃底平滑肌细胞为模板,观察了二氢吡啶类钙拮抗剂2,6-二甲基-4-(3-硝基苯基)-1,4-二氢-3,5-吡啶二羧酸-3-甲酯-5-正戊酯(Mn9202)、拉西地平对 5-HT_(2B)受体功能的影响,并对其影响机制进行了较为深入的研究。

Reactions of 2,6-pyridinedicarboxylic acid or 2,6-dibromomethyl pyridine with 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin, 5-(4-aminophenyl)-10,15,20 triphenyl porphyrin gave three novel bridged diporphyrins 3-5, respectively.

通过将2,6-吡啶二羧酸或2,6-二溴甲基吡啶分别与5-(4-羟基苯基)-10,15,20-三苯基卟啉(1)和5-(4-氨基苯基)-10,15,20-三苯基卟啉(2)反应,合成了3种新型的双卟啉化合物3~5。

In this paper, according to principles of molecular design, Cu,Ag, Cu,Fe, Ni, Mn, and Co were selected as templates, 8,8'-Dithiodiquinoline,4-cyanopyridine,2,2'-Bipyridyl-3,3'-dicarboxylic acid, 4,4'-bipyridine as building blocks.

本课题通过分子设计,以Cu,Cu,Mn,Co,Ni,Fe,Ag为模板,以8,8'-二硫联喹啉,4-氰基吡啶,4,4'-联吡啶和2,2'-联吡啶-3,3'-二羧酸为构件,用溶剂热法合成新的配位聚合物,测定其晶体结构,并研究其导电性和热行为。

Biological activity of the compounds were studied and the result indicated that the compound 1,1'-ethyl dicarboxylate gem-dimethyl-cyclopropanediacylhydrazine has good activity against bean aphidsin at 250mg/L.

生物活性测定结果表明,在250mg/L的浓度下,化合物1,1'-二羧酸乙酯偕二甲基环丙烷双酰肼对蚕豆蚜虫有较好杀虫活性。

This is the first example of two-dimensional lanthanide MOFs with one dimensional water chains.2、Coordination polymer[Nd_2_3(H_2O)_2]·bpy·4H_2O(2)(bpdc=2, 2′-bipyridine-3,3′-dicarboxylate,bpy=4,4′-bipyridine)had been synthesized under hydrothermal conditions and its structures were determined by X-ray diffraction,and confirmed by IR and TG analysis.

该结构是在二维骨架的镧系配位聚合物中首次观察到的一维的水链结构。2、以Nd_2O_3,2,2′-联吡啶-3,3′-二羧酸和4,4′-联吡啶为原料,采用水热法合成了一个具有二维骨架结构的配位聚合物[Nd_2_3(H_2O)_2]bpy·4H_2O,通过IR、x射线单晶衍射分析和热重等手段对其结构进行了表征。

Fumaric acid (trans-butenedioic acid) An unsaturated dicarboxylic acid, which occurs in many plants.

延胡索酸:一种不饱和二羧酸,存在于许多植物体中。

This dissertation is mainly focused on the reactivity of methylenecyclopropanes and comprises six parts. 1 The reactions of methylenecyclopropanes with phenylsulfenyl chloride, phenylselenyl chloride and diphenyl diselenide; 2 The coupling reactions of the ring-opening products derivated from methylenecyclopropanes; 3 The palladium-catalyzed ring-enlargement of mono-aryl group substituted methylenecyclopropanes to cyclobutenes. 4 The gold-catalyzed domino ring-opening and ring-closing hydroamination of methylenecyclopropanes with sulfonamides; 5 The Lewis acid-catalyzed reactions of mono-aryl group substituted methylenecyclopropanes with diethyl ketomalonate in the presence of water; 6 The iodobenzene diacetate mediated novel 1,3-dipolar cycloaddition of methylenecyclopropanes, vinylidenecyclopropanes, and methylenecyclobutane with phthalhydrazine.

本论文主要研究了亚甲基环丙烷类化合物的一些化学反应性能,共由以下六部分组成:1、亚甲基环丙烷类化合物与苯硫氯、苯硒氯及二苯基二硒的反应;2、亚甲基环丙烷类化合物开环产物的偶联反应;3、单芳基取代的亚甲基环丙烷类化合物在钯催化剂作用下的扩环反应;4、金化合物催化磺酰胺对亚甲基环丙烷类化合物的串联开环关环氨氢化反应;5、路易斯酸催化亚甲基环丙烷类化合物与丙酮二羧酸二乙酯在有水存在下的反应;6、醋酸碘苯促进的亚甲基环丙烷类化合物、亚乙烯基环丙烷类化合物及亚甲基环丁烷类化合物与邻苯二甲酰肼的新型1,3-偶极环加成反应。

In this thesis, five polydentate ligands including azido, oxalate, terephthalic acid, isophthalic acid and Pyridine-2,6-dicarboxylic acid were used to construct new transition metal complexes (M = Ru, Fe and Zn). Eight new complexes as listed below were synthesized and fully characterized.

本论文以草酸根、叠氮根、对苯二甲酸、间苯二甲酸和吡啶-2,6-二羧酸等含O、N的多齿共轭配体为研究对象,合成了以下八个结构新颖的化合物,并对它们的结构和谱学性质进行了详细的表征。

Norbornene-2,3-dicarboxylic acid monomethyl ester was prepared by using 5-norbornene-2,3- anhydride and methanol as raw materials and toluene as solvent.

以5-降冰片烯-2,3-二酸酐和甲醇为原料,正交试验法合成了5-降冰片烯-2,3-二羧酸单甲酯,并对产物结构进行了表征。

In this dissertation, preparation of polysubstituted ethene and heterocyclic compounds based on 2-hydroxyalkyl phenyl selenides andα-phenylselenopropionic acid reagents were further investigated as follow: Firstly, O-ethyl-O-vinyl phosphonates were prepared in a one-pot, two-step transformation by Mitsunobu reaction of 2-hydroxyalkyl phenyl selenides with monoethyl esters of phosphonic acid in the presence of diethyl azodicarboxylate and triphenyl phosphine (PPh3) followed by oxidation-eliminatio...

中文摘要:本文主要进一步探索了2-羟基烷基苯基硒醚、α-苯硒基丙酸试剂在制备多取代乙烯和杂环化合物反应中的应用,具体研究内容和结果如下:一、在偶氮二羧酸乙酯和三苯膦(PPh3)存在下,苯基-2-羟基烷基硒醚和O-乙基膦酸单酯发生Mitsunobu反应,无需分离和纯化反应中间体,直接使用30 %的双氧水进行氧化-消除反应,提供了&两步、一锅&合成O-乙基-O-乙烯基膦酸酯的新方法,该方法反应条件温和,操作简便,产物收率良好(76-82 %)。

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