二羧酸

Product 11 was transformed to the 2,6-difluoropyridine-4-carboxylic acid (12; 87%) by consecutive halogen/metal permutation and carboxylation.

产品11个，转化为2，6 -二氟- 4 -羧酸（12； 87％）的连续卤素/金属置换和羧化。

Eleven novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-oxadiazole derivatives (5) and six novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-thia- diazole derivatives (8) have been designed and synthesized by using 5-amino-3-ethoxycarbonyl-1H-1,2,4-triazole as a starting material.

以5-氨基－1H-1，2，4-三唑－3-羧酸乙酯为起始原料，设计合成了11个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-恶二唑类化合物(5)和6个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-噻二唑类化合物(8)。

The process is carried out by taking organic acid and sulfoxide chloride as raw materials, acyl chloride synthesizing, reacting ethylenediamine with sodium chloroacetate to synthesize intermediate sodium EDDA, and reacting it with acyl chloride to synthesize the final product.

所述双子烷基羧酸盐表面活性剂是由以下方法制得的，以有机酸和氯化亚砜为原料首先进行酰氯的合成，再用乙二胺与氯乙酸钠反应合成中间体乙二胺二乙酸钠，将中间体乙二胺二乙酸钠与酰氯反应合成终产物。

Purified protein samples were separated by 2-DE with 17 cm IPG strips, and the protein spots were detected by fast silver staining. Six protein spots were randomly excised from the silver stained gel for primary analysis by MALDI-TOF MS. Four proteins were identified, and they were 1-aminocyclopropane-1-carboxylate synthase 2, ribulose-1, 5-bisphosphate carboxylase/oxygenase large subunit, F11O4.2 and Rubisco small subunit.

根据预实验结果，选用17 cm IPG预制干胶条对纯化的蛋白样品进行2-DE实验，采用快速银染法进行染色，随机挖取银染胶上6个蛋白点进行MALDI-TOF MS分析和数据库检索，鉴定了3个蛋白，它们是：1-氨基环丙烷-1羧酸合酶2，核酮糖-1，5-二磷酸羧化酶/加氧酶大亚基和F11O4.2。

Dichlo-5- carboxylic acid Rhodamine is a kind of bright flurescent using xanthene as scaffold, whose aryl-H was substituted with a variety of groups. Compared with any other rhodamine, they can increase or decrese emissive absorbance in most limitation.

4，7，-二氯-5(和6)-羧酸罗丹明荧光染料是一种带有羧基官能团的荧光染料，作为一种特殊的抗体染色剂，在生物，医药方面具有广泛的应用，能标记DNA和蛋白质等大分子，这些性能被广泛应用于DNA分离和定序的研究中。

A novel liquid crystalline compound named p-phenylenediamine di 4-[2- benzamide] was synthesized from allyl 2-hydroxyethylether, ethyl 4-hydroxybenzoate and p-phenylenediamine.

以乙二醇单烯丙基醚、对羟基苯甲酸乙酯、对苯二胺为原料合成了末端为不饱和双键的芳香聚酰胺溶致型液晶化合物——二对烯丙氧基乙氧基苯甲酰对苯二胺，最佳合成的摩尔比为∶羧酸∶对苯二胺∶吡啶=2。

A process for the carbonylation of allylic butenyl ether (for example, methyl crotyl ether, 3-methoxybutene-1 and mixtures thereof) or mixture of butadiene and alcohol and production of beta-gamma unsaturated carboxylic acid esters (for example, methyl-3-pentenoate) utilizing a rhodium-containing catalyst for example, dicarbonylacetylacetonate rhodium(I or the like promoted with an iodide-containing compound (for example, HI, AlI3, SnI4, TiI4, CrI3, and CoI2 or the like).

一种将烯丙型丁烯基醚(如甲基巴豆基醚、3－甲氧基丁烯－1及其混合物)或者丁二烯与醇的混合物羰基化的方法，以及由含碘化物化合物(如HI、AlI3、SnI4、TiI4、CrI3和CoI2或等效物)促进，用含铑催化剂如二羰基乙酰丙酮酸铑(I或其等效物制备β－γ不饱和羧酸酯(如甲基－3－戊烯酸酯)的方法。

Based on hydrogen peroxide and ammonium persulfate as compounded initiating system,unsaturated vinyl monomers were used to directly copolymerize a new high range polycarboxylate water reducer structurized in carboxyl,esterquat and amido as main chain and in polyethylene glycol ether as side chain.

以过硫酸铵和双氧水为复合引发体系，采用不饱和单体直接共聚，得到一类主链为羧基、酯基、酰胺基，侧链为聚乙二醇醚基的新型聚羧酸高效减水剂，研究了共聚物的结构对分散性能的影响。

Inthis papor,we synthesize and symbolize three sulphide bicarboxylate ligands such as 2.5-bis-1.3,4-thiadiazole;2,2 -(o-phenylenedimethylenethio) diacetic acid(L11); 2,2 -(m-phenylenedimethylenethio) diacetic acid.

本文合成和表征了2，2′-(1，3，4-噻二唑-2，5-二硫基)二乙酸、2，2′-邻苯二甲硫基二乙酸和2，2′-间苯二甲硫基二乙酸三个含硫二元羧酸配体。

Itamin D from the skin and diet is metabolized in the lier to 25-hydroxyitamin D (Figure 1), which is used to determine a patient's itamin D status1,2,3,4; 25-hydroxyitamin D is metabolized in the kidneys by the enzyme 25-hydroxyitamin D-1-hydroxylase (CYP27B1) to its actie form, 1,25-dihydroxyitamin D.1,2,3,4 The renal production of 1,25-dihydroxyitamin D is tightly regulated by plasma parathyroid hormone leels and serum calcium and phosphorus leels.1,2,3,4 Fibroblast growth factor 23, secreted from the bone, causes the sodium–phosphate cotransporter to be internalized by the cells of the kidney and small intestine and also suppresses 1,25-dihydroxyitamin D synthesis.5 The efficiency of the absorption of renal calcium and of intestinal calcium and phosphorus is increased in the presence of 1,25-dihydroxyitamin D (Figure 1).2,3,6 It also induces the expression of the enzyme 25-hydroxyitamin D-24-hydroxylase (CYP24), which catabolizes both 25-hydroxyitamin D and 1,25-dihydroxyitamin D into biologically inactie, water-soluble calcitroic acid.2,3,4

从皮肤和食物来的维生素D在肝中代谢为25-羟基维生素D（图1），被用来决定病人体内维生素D情况的1，2，3，4；25-羟基维生素D在肾中被25-羟基维生素D1羟化酶（CYP27B1）转变为有活性的1，25-二羟基维生素D 。1，2，3，4由肾产生1，25-二羟基维生素D是被血浆甲状旁腺激素和血清钙，磷水平紧密调节。1，2，3，4由骨分泌的成纤维细胞生长因子23使钠磷协同转运蛋白被肾和小肠细胞内化及抑制1，25-二羟维生素D合成。5 在1，25-二羟基维生素D作用下肾和小肠吸收钙及磷的效率增高(图1)。2，3，6 它也包括25-羟四- 24 -羟化酶的表达(CYP24)，且将1，25二羟基维生素D和25羟基维生素D异化成无生物活性，水溶性的维生素D3-23羧酸。2，3，4

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新