二羧基的

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

Any of various natural or synthetic compounds containing two or more amino acids linked by the carboxyl group of one amino acid and the amino group of another.

肽一种自然或人工的合成物，包括二个或二个以上氨基酸，通过一个氨基酸的酸基和另一个的羧基结合而成

We examined the effects and mechanisms of methyl pentyl 1,4-dihydro-2,6-dimethyl-4-(3-notrophenyl)-3,5-pyridinedicarboxylate (Mn9202), a novel DHPs calcium antagonist and lacidipine on the 5-HT2B receptor in cultured rat stomach fundus smooth muscle cells.

本研究以富含5-HT_(2B)受体的大鼠胃底平滑肌细胞为模板，观察了二氢吡啶类钙拮抗剂2，6-二甲基-4-（3-硝基苯基）-1，4-二氢-3，5-吡啶二羧酸-3-甲酯-5-正戊酯（Mn9202）、拉西地平对 5-HT_(2B)受体功能的影响，并对其影响机制进行了较为深入的研究。

Dichlo-5- carboxylic acid Rhodamine is a kind of bright flurescent using xanthene as scaffold, whose aryl-H was substituted with a variety of groups. Compared with any other rhodamine, they can increase or decrese emissive absorbance in most limitation.

4，7，-二氯-5(和6)-羧酸罗丹明荧光染料是一种带有羧基官能团的荧光染料，作为一种特殊的抗体染色剂，在生物，医药方面具有广泛的应用，能标记DNA和蛋白质等大分子，这些性能被广泛应用于DNA分离和定序的研究中。

A process for the carbonylation of allylic butenyl ether (for example, methyl crotyl ether, 3-methoxybutene-1 and mixtures thereof) or mixture of butadiene and alcohol and production of beta-gamma unsaturated carboxylic acid esters (for example, methyl-3-pentenoate) utilizing a rhodium-containing catalyst for example, dicarbonylacetylacetonate rhodium(I or the like promoted with an iodide-containing compound (for example, HI, AlI3, SnI4, TiI4, CrI3, and CoI2 or the like).

一种将烯丙型丁烯基醚(如甲基巴豆基醚、3－甲氧基丁烯－1及其混合物)或者丁二烯与醇的混合物羰基化的方法，以及由含碘化物化合物(如HI、AlI3、SnI4、TiI4、CrI3和CoI2或等效物)促进，用含铑催化剂如二羰基乙酰丙酮酸铑(I或其等效物制备β－γ不饱和羧酸酯(如甲基－3－戊烯酸酯)的方法。

Thiazolidiane-4-carboxylic acid was prepared and used as the aid catalyst that has strengthened the catalytic effect of chloroplatinic acid, greatly improved the yield of the hydrosilylation of methyldichlorosilane with allychloride, and made the yield get to 64.9%.

通过比较，选用自制的含硫化合物4-羧基-1，3-噻唑烷作助催化剂，大大增强了氯铂酸的催化活性，使甲基二氯硅烷与氯丙烯的加成反应以较高产率得到γ-氯丙基甲基二氯硅烷，产率可达64.9%。

Investigation of major metabolic pathways of SFZ-47 in animals The metabolites of SFZ-47 in rabbit urine following oral administration were separated and detected with HPLC and LC-MS methods. On the basis of the chromatographic behavior and mass spectra of the metabolites as well as biotransformation pathways of drugs with the partial structure of SFZ-47, the hydroxylic derivative 4-(3H-1, 2- dihydro-1-pyrrolizinone-2-methylamino benzyl alcohol and the carboxylic derivative 4-(3H-1, 2-dihydro-1-pyrrolizinone-2-methylamino benzoic acid of SFZ-47 were proposed as two potential metabolites and were synthesized.

在动物体内主要代谢途径的确定用HPLC和LC-MS对家兔口服SFZ-47后尿中的代谢物进行了分离、检测，根据代谢产物的色谱和质谱行为以及与SFZ-47有类似结构部分的其它药物的代谢途径，推测其羟基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲醇]与羧基衍生物[4-（3H-1，2-二氢-1-吡咯里嗪酮-2-甲基胺基）苯甲酸]是两种可能的代谢产物，遂用化学方法合成了这两种衍生物。

The pathway The first committed step in Fatty acid biosynthesis is the carboxylation of acetyl CoA to form malonyl CoA which is catalyzed by the biotin-containing enzyme acetyl CoA carboxylase.

途 径 脂肪酸合成的第一个关键步骤是乙酰-COA 羧基化形成丙二酰单酰 COA ，这一步是在含生物素的酶乙酰-COA 羧化酶的催化下进行的。

Comb-shaped copolymer of polycarboxylate containing carboxyl,sulfonic groups(-SO3M),polyethylene glycol(-OC2H4-) was synthesized by monomers of sodium 2-acrylamido-2-methylpropane sulphonate,acrylic acid,polyethylene glycol monoester acrylate under certain conditions.

本文通过2-丙烯酰胺-2甲基丙基磺酸钠与丙烯酸、聚乙二醇单丙烯酸酯在一定条件下发生聚合反应合成含有羧基、磺酸基(—SO3M)、聚氧乙烯链(—OC2H4—)等侧链的高性能减水剂PC。

Macrocycle with two aryl oxdiazolesThe structure of this type of macrocyclic compounds with two aryloxdiazoles attached to the nitrogen atom of amino acids is different fromthat of the above compounds.

三。含双噁二唑的大环：在这类分子中两个芳基噁二唑通过氨基酸的氮原子连接成环，而将手性中心和羧基端放于环外，这可提高分子的络合性能。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。