二羟基苯

Three ways leads to the synthesis of fenclorin, one way discussed here has 3 steps. Stepl :benzonitrile using as raw material goes though dry hydrogen chloride and becomes a-imino phenylmethyl ether after meet carbinol.

解草啶的合成主要有三条路线，本文选取合成路线是以苯甲腈为原料，经三步反应而成：1、苯甲腈在干燥的氯化氢通入，与甲醇形成亚氨基苯甲醚，通入氨气后置换甲氧基得到苯基脒盐酸盐(收率76.18%)。2、苯基脒盐酸盐在碱性条件下与丙二酸二乙酯环合而得嘧啶醇(收率84.39%)。3、嘧啶醇在三氯氧磷中羟基被氯化得到产品解草啶(收率87.29%)。

Therelationship of the amount of catalyst and the ee% of product was seen to be negative nonlin-ear. Catalyst 3 was used in the enantioselective addition of diethylzinc to aromatic aldehydesand gave good results. The configuration of products was determined by the configuration ofthe catalysts' chiral carbon linked with hydroxy group. Using β- amino alcohols bearing only one chiral center as catalysts for the enantiose-lective addition were studied. D-N, N-dialkyl-2-amino butanol gave poor catalytic effect be-cause of their structure. The configuration of the product is the same as the catalyst. Anotherkind of β- amino alcohols - phenylglycine derivatives and valine derivatives have chiralcenter on the carbon linked with amino group. Catalyzed by-phenylglycine derivatives 6,7, 9, 10, the reactions gave satisfied results. The optical yields exceeded 80%.

在探讨了含有两个手性中心的β-氨基醇之后，选择了只有一个手性中心的β-氨基醇，一是手性中心为连羟基的手性碳原子：D-N，N-二烷基-2-氨基丁醇；二是手性中心为连氨基的手性碳原子：D-苯基甘氨酸衍生物和L-缬氨酸衍生物。D-2-氨基丁醇的催化效果不太好，这与其结构的空间位阻较小有关系，反应产物与连羟基手性碳构型一致；由苯基甘氨酸和缬氨酸出发合成五种β-氨基醇6-10，研究了不同ee％的-6作用下的二乙基锌-苯甲醛加成反应，发现该催化剂具有不对称放大效应；-7，9，lO的催化效果也比较令人满意，光学产率80％以上，所得产物构型与催化剂构型一致。

Benzyloxy benzoyldimethylsulfoxide was prepared by the reaction of ethyl 4-benzyloxybenzoate and dimethyl sulfoxide in the presence of sodium hydride, followed by Pummerer reaction with concentrated hydrochloric acid to afford eo-hydroxy-co-thio-methyl-(4/-benzyloxy) acetophenone, which reacted with urea, thiosemicarbazide, semicarbazide hydrochloride and o-phenylenediamine to give imidazolidine-2,4-dione, l,2,4-triazine-3- one and quinoxaline derivatives, respectively.

本文用4-苄氧基苯甲酸乙酯和二甲亚砜为原料，在氢化钠存在下反应，合成了(4′-苄氧基)-苯甲酰基-二甲亚砜。研究了该亚砜在浓盐酸的存在下发生的Pummerer重排反应，用重排产物ω-羟基-ω-甲硫基-(4′-苄氧基)-苯乙酮分别与尿素、氨基脲、氨基硫脲和邻苯二胺反应合成了2，4-咪唑啉-二酮、1，2，4-三嗪-3-酮、喹喔啉等含氮杂环化合物。

The experiments also show that adding NaHSO3 into the reaction liquid of hydroxylation reaction can inhibit the catalytic effect of benzoquinone and residual catalyst on the phenolic tars formation caused by oxo-condensation of the diphenols and therefore reduce the tars formation of the diphenols in the reaction solution.

在羟基化反应液中加入亚硫酸氢钠可以抑制对苯醌和残留催化剂对苯二酚氧化缩合生成焦油的催化作用，从而减少了反应液中苯二酚的生焦反应。

Two novel soluble poly, poly [(3-butyrylpyrrole-2, 5-diyl) p-nitrobenzylidene] and poly [(3-butyrylpyrrole-2, 5-diyl)(3-hydroxy-4-methoxy) benzylidene], were synthesized firstly by condensation of 3-butyrylpyrrole with p-nitrobenzaldehyde and vanillin, respectively.

通过3-丁酰基吡咯单体分别与对硝基苯甲醛和香草醛的缩聚反应，成功合成了两种新型可溶性聚吡咯甲烯衍生物－策［（3-丁酰基吡咯－2，5-二）对硝基苯甲烯］和聚［（3-丁酰基吡咯－2，5-二）（3-羟基－4-甲氧基）苯甲烯］。

Ingredients: water,glycerin,caprylic/capric triglyceride,cetyl alcohol,squalane,glyceryl stearate,panthenol,betaine,dimethicone,lavandula angustifoliaoil,allantoin,carbomer,xanthan gum,parfum,triethanolamine,tocopheryl acetate,hyaluronic acid,methyl paraben,propyl paraben,creatine,tetrasodium edta,phenoxyethanol,caprylyl glycol,sorbic.

成分：去离子水，甘油，辛酸/葵酸三甘油酯，鲸蜡醇，角鲨烷，硬脂酸甘油酯，泛醇，甜菜碱，聚二甲基硅氧烷，薰衣草精油，尿囊素，卡波姆，汉生胶，香精，三乙醇胺，生育酚乙酸酯，透明质酸，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，肌酸，乙二胺四乙酸四钠，苯氧乙醇，辛二醇，山梨酸。

Ingredients:Water,Glycerin,Caprylic/Capric Triglyceride,Cetearyl Alcohol,Squalane,Glyceryl Stearate,Panthenol,Betaine,Dimethicone,Oiea Europaea Oil,Allantoin,Glyceryl Stearate Se,Carbomer,Xanthan Gum,Parfum,Triethanolamine,Tocopheryl Acetate,Hyaluronic Acid,Methyl Paraben,Propyl Paraben,Creatine,Tetrasodium Edta,Phen-oxyethanol,Caprylyl Glycol,Sorbic.

成分：去离子水，甘油，辛酸/葵酸三甘油酯，鲸蜡硬脂醇，角鲨烷，硬脂酸甘油酯，泛醇，甜菜碱，聚二甲基硅氧烷，橄榄油，尿囊素，自乳化硬脂酸甘油酯，卡波姆，汉生胶，香精，三乙醇胺，生育酚乙酸酯，透明质酸，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，肌酸，乙二胺四乙酸四钠，苯氧乙醇，辛二醇，山梨酸。

Ingredients:Water,Glycerin,Caprylic/Capric Triglyceride,Myristyl Myristate,Butyrosper-mum Parkii Butter,Glyceryl Stearate,Panthenol,Betaine,Dimethicone,Oiea Europaea Oil,Allantoin,Polysorbate-60,Carbomer,Xanthan Gum,Parfum,Triethanolamine,Tocopheryl Acetate,Hyaluronic Acid,Methyl Paraben,Propyl Paraben,Creatine,Tetrasodium Edta,Phenoxyethanol,Caprylyl Glycol,Sorbic.

成分：去离子水，甘油，辛酸/葵酸三甘油酯，肉豆蔻酸肉豆蔻酯，乳木果油，硬脂酸甘油酯，泛醇，甜菜碱，聚二甲基硅氧烷，橄榄油，尿囊素，聚山梨醇酯-60，卡波姆，汉生胶，香精，三乙醇胺，生育酚乙酸酯，透明质酸，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，肌酸，乙二胺四乙酸四钠，苯氧乙醇，辛二醇，山梨酸。

Ingredients: Water,Glycerin,Caprylic/Capric Triglyceride,Myristyl Myristate,Butyrospermum Parkii Butter,Glyceryl Stearate,Panthenol,Betaine,Dimethicone,Hydrolyzed Collagen,Allantoin,Polysorbate-60,Carbomer,Xa-nthan Gum,Parfum,Triethanolamine,Tocopheryl Acetate,Hyaluronic Acid,Methyl Paraben,Propyl Paraben,Creatine,Tetrasodium Edta,Phenoxyethanol,Caprylyl Glycol,Sorbic.

成分： 去离子水，甘油，辛酸/葵酸三甘油酯，肉豆蔻酸肉豆蔻酯，乳木果油，硬脂酸甘油酯，泛醇，甜菜碱，聚二甲基硅氧烷，水解胶原蛋白，尿囊素，聚山梨醇酯-60，卡波姆，汉生胶，香精，三乙醇胺，生育酚乙酸酯，透明质酸，对羟基苯甲酸甲酯，对羟基苯甲酸丙酯，肌酸，乙二胺四乙酸四钠，苯氧乙醇，辛二醇，山梨酸。

This paperindicated that it was good for condensation reaction when benzene-ring bearingelectron-attaching groups. It also showed that and the 6-hydroxyl group could bereacted with acyl halide, haloid ether and halo alkene, but not with halo alkane. It wasnot only the first time to find that the reaction product of D-mannitol and aromaticaldehyde is tri-condensation derivatives, but also the first time to obtain thep-phthaldehyde-sorbitol derivatives containing eight hydroxyl groups.

研究发现：苯环上有吸电子基团时对缩合反应有利；多元醇缩醛衍生物6-羟基除与酰氯反应外，也能和卤代酸酯、溴代烯反应，但不与卤代烷反应；首次发现D-甘露醇与醛反应主要得到三缩合物；首次合成了含有8个羟基的对苯二甲醛和山梨醇的缩合物。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。