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TGF-βbinds to a heteromeric complex of type I and type II receptors. The constitutively active type II receptor phosphorylates and activates the type I receptor which phosphorylates Smad2 and Smad3 (receptor-associated Smads). Receptor-associated Smads bind the common mediator Smad4 and are translocated to the nucleus, where they associate with DNA-binding cofactors to modulategene transcription.

TGF-β与其效应细胞表面的Ⅱ型受体TβRⅡ和Ⅰ型受体TβRⅠ形成的异源二聚体结合,相继激活TβRⅡ和TβRⅠ,活化的TβRⅠ再进一步活化Smad2和Smad3,磷酸化的Smad2/3必须与Smad4结合形成复合物,才能进入细胞核,调节靶基因的转录[6]。

The polyvinyl chloride static and dynamic experiments of the heat stability by three novel low-lead, non-lead and low-tin, and non-lead and non-tin thermal stabilizers remixed respectively with phosphite ester, epoxidized soybean oil,β-diketone, pentaerythritol and houghite were reviewed.

通过新型低铅、无铅低锡和无铅无锡热稳定剂分别与亚磷酸酯、环氧大豆油、β-二酮、季戊四醇和水滑石进行复配,进行了聚氯乙烯的静态和动态热稳定性实验。

Diabetes was induced by streptozotocin (55 mg/kg body wt by intraperitoned injection) which was dissolved in citric acid-phosphate buffer PH4. 4 and verified 24 hours later by the presence of hyperglycemia and hyperglycosuria.

糖尿病模型制备方法按55mg/kg STZ剂量向大鼠腹腔内一次性注射链脲佐菌素(Streptozotocin,STZ),STZ予先溶于PH4.4的柠檬酸—磷酸氢二钠缓冲液中,制成浓度为20mg/ml溶液。24h后测尿糖和血糖,尿糖在+++和++++,血糖在16mmol/l以上者确定为糖尿病。

In this paper, Ti PbO 2 and Ti Ru used as anode and stainless steel used cathode in producing hypophosphorous acid by electrolytic process with four compartment electrodialytic cell was studied.

本文采用四室电渗析槽,分别以钛涂钌电极和钛基二氧化铅电极为阳极,不锈钢为阴极,进行了电解法制备次磷酸的实验研究。

An unreported compound 2-cyclopropylbenzimidazolium salt was obtained from 2-cyclopropyl benzimidazole and iodomethane.

以邻苯二胺和环丙基甲酸为原料,以多聚磷酸为催化剂,在微波辐射下合成了环丙基苯并咪唑,用碘甲烷季胺化得到未见文献报道的环丙基苯并咪唑盐,通过苯并咪唑盐与Grignard试剂加成后水解反应制备环丙基甲基酮。

The result fights allergic experiment to show, dispel the wind stops land of can different level restrains urticant Ding allergy of akin and passive skin mixes the bandicoot that antiserum causes 2, the sex of small rat late hair of chloric benzene be caused by exceeds 2 nitro- of 4- quick the thymus index that reaction; still can increase small rat when dosage greatly and lienal index; stop urticant experiment shows, dispel the wind stops urticant Ding can reduce the time of fit of small rat itching with dextrose lead anhydride and itching duration apparently, can increase Guinea pig to be able to bear or endure those who suffer phosphoric acid histamine send urticant threshold.

结果抗过敏试验显示,祛风止痒酊能不同程度地抑制抗血清诱发的大鼠同种被动皮肤过敏和2,4-二硝基氯苯所致的小鼠迟发性超敏反应;大剂量时还可增加小鼠的胸腺指数及脾指数;止痒试验显示,祛风止痒酊能明显降低右旋糖酐诱导的小鼠搔痒发作次数及搔痒持续时间,并能增加豚鼠耐受磷酸组胺的致痒阈。

This product can suppress the activity of PDE III, reduce the infiltration of oil, and promote the synthesis of hormone-sensitive type esterase, thus has the effects of decomposing and releasing lipocyte lipid.

抑制磷酸二酯酶Ⅲ活性,减少油脂渗入,并促进激素敏感型酯酶的合成,从而具有分解和释放脂肪细胞内脂质的作用。

The density functional theory and MP2 method were employed to study the reaction pathways of methanolysis of 3-methyl cyclic ethylene phosphate: CH3O-+MEP; CH3OH+MEP; CH3O-+HMEP; CH3OH+HMEP.

采用密度泛函理论和MP2方法研究了3-甲基环状乙撑磷酸二酯与甲醇的反应途径: CH3O-+MEP; CH3OH+MEP; CH3O-+HMEP; CH3OH+HMEP。

This method conformed the following conditions: spleen phosphodiesterase and micrococcal nulcease for digesting reagent and the concentration, temperature and digesting time of the two enzymes;the components of p32-post label alleviant and labeling time;the concentration of p1 nuclease; the concentration of T4 polynucleotide kinase for catalysing and labeling reagent;the components of bidirectional spreader and the spreading time ,etc.

确定了采用脾磷酸二酯酶和微球菌核酸酶消化底物以及两种酶的使用浓度、温度及消化时间;确定了P32标记缓冲液的主要成分及标记时间;确定了P1核酸酶的浓度;确定了T4多核苷酸激酶催化标记底物的浓度;确定了双向展开剂的主要成分及展开时间等。

Pingxiang Iron and Steel Co., Ltd. has developed a de-cyanide pretreatment technology with molysite, but the concentration of CN - at a range of 10~18 mg/L in the wastewater after treating is still too high as for germ in dephenolization. The influence o...

根据对活性污泥的驯化过程对脱酚活性污泥影响的研究,得出适于细菌生存繁殖的运行参数为磷酸二氢钠加入量 12kg/d以上,葡萄糖 9kg/d以上,自沉污泥指数约 2 0mL/10 0mL ,回流污泥指数约 30mL/10 0mL ,温度为 2 5~35℃。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。