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二甲苯

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Results The water extract from Radix et Caulis Ilicis Asprellae could inhibit xylene-induced ear edema and capillary permeability increase in mice, hind paw edema and PGE2 increase induced with carrageen and granuloma induced with cotton ball in rats.

结果 岗梅水提取物能明显抑制二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致的大鼠足跖肿胀及炎性组织中PGE2的生成

Methods The model of acute inflammation was made on rats or mice by xylol,croton oil and carrageen in the model of chronic inflammation was made by cotton-pellets,and the model of tumor was made by S 180 and H 22 .The action of anti-inflammation,anti-carcinogen and the rate of life extension were observed.

二甲苯、巴豆油、角叉菜胶造成大、小鼠急性炎症模型;用棉球肉芽肿造成小鼠癌症模型,用S 180 、H 22 瘤株造成小鼠癌症模型,观察高丽灵散的抗炎、抗癌作用及生命延长率。

Results:MCP had antipyretic effect on big rats with fever caused by yeast and antiindlammatory on rats with plantar inflammation caused by egg white and carrageen and auris inflammation caused by dimethylbenzenne.It also had inhibitory effect on tampon granuloma and cough caused by ammoria.

结果 :麝香牛黄丸对酵母致热大鼠有解热作用;对大鼠蛋清、角叉菜胶足跖肿和小鼠二甲苯耳肿胀有明显的抗炎作用,对大鼠棉球肉芽肿的形成有一定的抑制作用,并能减轻氨水导致的咳嗽。

Methods Analgesic effects of Shengning suppository were observed with pain model mice by acetic acid or hot plate test. Antiinflammatory effects were studied with ear acute edema model induced by dimethylbenzene in mice and rat foot edema model induced by carrageen, and antipruritic action was observed with allergic pruritic model caused by histamine in guinea pigs.

采用二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀炎症模型,热板法和扭体法及磷酸组织胺的致痒试验,观察参宁栓的抗炎、镇痛、止痒作用。

Methods The mice were given the meloxican tablet, ig, at the dosage of 0.56,1.13,2.25 and 9.00 mg.kg-1, then ip 0.8%acetic acid, and injecting the ear of mice. The meloxicans were given to rats, at the dosage of 1.5,3.0,6.0 mg.kg-1, to observe the effect of the meloxican inhibiting the paws swelling of rats by carrageen and granulation of rats by paper method.

观察美洛昔康对醋酸导致小鼠血管通透性增加和二甲苯引起小鼠耳肿胀抑制作用,以及角叉菜胶诱发大鼠足肿胀和纸片法引起大鼠肉芽增生的抑制作用。

Methods: YTLP and aspirin were introduced to treat the edematous ears of mice induced by xylene and swollen toes of mice induced by carrageenin, and to relieve the pain in mice induced by heat and acetic acid.

以阿司匹林为对照药物,将一贴灵贴剂用于治疗二甲苯所致的小鼠耳肿胀和角叉采胶所致的大鼠足趾肿胀,以及热和醋酸所致的小鼠疼痛,测量肿胀度、痛阈值及扭体次数。

Methods Animal inflammatory models were established by injection of dimethylbenzene for mice ear swelling, carrageenin for rat footpad, cotton pellet wool for rat granuloma respectively. The content of prostaglandin E2(PGE2) and leukotriene B4(LTB4) from peritoneal macrophages were measured by RIA and RP-HPLC respectively.

采用二甲苯诱导的小鼠耳肿胀、角叉菜胶诱导的大鼠足肿胀、棉球诱导的大鼠肉芽肿模型观察TFC的抗炎作用;分别采用放射免疫法和反相高效液相色谱法检测TFC对大鼠腹腔巨噬细胞产生前列腺素E2(PGE2)和白三烯B4(LTB4)的影响。

The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。

Methods Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti- inflammatory action of CSC. Its acute toxicity in mice was also evaluated.

方法]采用细菌脂多糖致家兔发热、啤酒酵母致大鼠发热动物模型,观察穿心莲软胶囊的解热作用;采用角叉菜胶致大鼠足肿胀、二甲苯致小鼠耳肿胀和醋酸致小鼠腹腔毛细血管通透性增加的动物模型,观察穿心莲软胶囊的抗炎作用,并对小鼠进行该制剂的急性毒性试验。

Pae (25-100mg/kg, ip) not only inhibited the swelling of mouse pinnea induced by xylene in a dose-dependant manner, but also suppressed the edema of rat hind paw induced by injection of 1% carrageenin at a higher dose (100 mg/kg, ip).

Pae(25-100mg/kg,ip)可剂量依赖性地抑制二甲苯所致的小鼠耳肿胀,高剂量(100mg/kg,ip)时可抑制角叉菜胶所致的大鼠足跖肿胀。

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