二甲双胍

The biguanide metformin is one of the mostly used drugs for treatment of type 2 diabetes.

二甲双胍是一种胰岛素增敏剂，多年来被广泛应用于对2型糖尿病患者的降血糖治疗。

METHODS:186 cases with type 2 diabetes mellitus were randomized to 3 groups:Group A was treated with acarbose;Group B was treated with dimethyl biguanide and Group C was treated with gliclazide.

将186例2型糖尿病患者随机分成3组，分别用阿卡波糖、二甲双胍和格列齐特治疗，并进行药物经济学成本-效果分析。

All menstrual disorder patients took orally diane 35 and patients accompanied with insulin resistance added biguanide again.

对所有月经异常者口服达英-35，伴胰岛素抵抗者加二甲双胍治疗。

The experimental group for the dimethyl biguanide plus fuzhenghuatanhuoxue prescription, and the control group for dimethyl biguanide only.

两组患者均给予糖尿病教育，饮食控制，适量运动，根据血糖情况调整二甲双胍的剂量，2个月为一疗程。

Methods After formation of the experimental diabetic mice models by injecting alloxan with the dose of 120 mg/kg body weight, 30 experimental diabetic mice （20 ± 2g at the beginning） were divided into four groups at random, Group A were given physiological saline as control group, While Group B and C were given low dose （ 125 mg/kg bw） and tfigh dose （250 mg/kg bw） LTN respectively, Group D were given Dimethyl Biguanide Hydrochlorie Aeid.

方法体重（20 2）g清洁级BALB/C小鼠30只腹腔注射四氧嘧啶（120 mg/kg）建立糖尿病动物模型，并将其随机分成4组，分别用生理盐水、低剂量（125mg/kg）和高剂量（250mg/kg）香菇多糖以及盐酸二甲双胍灌胃，试验期21 d，观察、比较香菇多糖的作用。

It is conclinical practice included dimethyl biguanide,glipizide,gliclazide and glibenclamide.

二甲双胍、格列吡嗪、格列齐特、格列本脲等目前用药活跃，仍为主要降糖药。

Methods: Screens 983 example metabolism syndrome patient from the immortal river area healthy physical examination staff, the blood sugar unusual 675 examples will carry on the grouping, branches out the pure IFG group, the IFG+IGT group and diabetes group through the OGTT experiment (has explicit diabetes medical history not to carry on the OGTT experiment), conducts the intervention research to the pure IFG group 117 examples, divides into the life style intervention group, the life style add two armor biguanide intervention group and the control group, after the research intervention treatment, this part of patient's extension to turn over to the situation.

从仙河地区健康查体职工中筛选出983例代谢综合征患者，将其中血糖异常的675例进行分组，通过OGTT试验分出单纯IFG组、IFG+IGT组和糖尿病组(有明确糖尿病病史者不进行OGTT试验)，对单纯IFG组117例进行干预研究，分为生活方式干预组、生活方式加二甲双胍干预组和对照组，研究干预治疗后这部分病人的转归情况。

Part I Clinical study on serum leptin and IGF-1 levels in patientswith polycystic ovary syndromeObjective To determine whether PCOS is related to leptin, IGF-1 and IGFBP-1 dysregulation and to investigate the relationship between endocritic and metabolic disorders.

国内关于瘦素、胰岛素样生长因子-Ⅰ对生殖功能影响的研究极少，对于二甲双胍治疗PCOS后，瘦素及其它相关因子的研究未见报道。

OBJECTIVE To observe the effect of Plumula Nelumbinis Nuciferae and neferine on models of experimental diabetes and obesity made with streptozotocin and high carbohydrate and lipid, compared with the effect of metformin.

目的 观察莲子心及甲基莲心碱(neferine ，Nef)对链脲佐菌素(streptozotocin ，STZ)和高糖高脂制作的大鼠糖尿病及肥胖模型的影响，并与二甲双胍(metformin ，Met)作对照。

Objective To investigate the role of insulin in the polycystic ovary syndrome pathogenesis and application of Metformin in the treatment of PCOS.

目的 探讨高胰岛素血症在多囊卵巢综合征发病中的作用及二甲双胍对PCOS的治疗效果。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。