二甲双胍

Abstract］ Objective: To investigate the effects of metformin in the treatment of young obese women with amenorrhea.

目的：观察二甲双胍对年轻女性肥胖伴停经的治疗效果。

Metformin had significant effect in young obese women with amenorrhea.

二甲双胍对肥胖伴停经的女性有一定的治疗作用。

Purpose To establish a RP Ion-pair HPLC method for the determination of dicyandiamide in metformin hydrochloride.

目的 建立反相离子对HPLC法测定盐酸二甲双胍中双氰胺含量的方法。

Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial

对2型糖尿病的非肥胖患者使用胰岛素结合二甲双胍或胰岛素促泌剂：12个月，随机，双盲试验

Methods: Glipizide gliclazide glyburide glimepiride gliquidone repaglinide nateglinide pioglitazone rosiglitazone metformin phenformin and tolbutamide added in the blank ground samples were extracted with 80% methanol and were separated from an ACQUITY UPLC DBH C18 column with a gradient mobile phase of acetonitrile - 0.2 % formic acid water solution. A tandem quadrupole mass spectrometer equipped with electrospray ionization source was used in positive ion mode multiple reaction monitoring was performed to quantify above mentioned compounds.

被添加在中成药制剂及其包装物中的二甲双胍、苯乙双胍、罗格列酮、吡格列酮、格列吡嗫娶瑞格列奈、甲苯磺丁脲、格列齐特、格列苯脲、那格列奈、格列美脲、格列喹酮等西药成分用80%甲醇提取，以乙腈- 0.2%甲酸水溶液为流动相梯度洗脱，在ACQUITY UPLC DBH C18色谱柱上分离，串联四级杆质谱检测，MRM方式采集并定量。

Results The highest drug use frequency was biguanide. There was 50.9% in the oral antidiabetic drug combination. Leading the first 3 places on the list of drug combination were sulfonylureas in combination with biguanide, sulfonylureas in combination with α-Glycosidace inhibitor, biguanide in combination with α-Glycosidace inhibitor, while there was 16.1% in 3 kinds combination. When oral antidiabetic drugs were combined with other drugs, combination with antihypertensives drugs led the fist, while with antihypertensives drugs led the second.

结果 二甲双胍使用频率最高，口服降糖药联合用药的比例高达50.9%，居前3位的依次是磺脲类＋双胍类、磺脲类＋α-葡萄糖苷酶抑制剂和双胍类＋α-葡萄糖苷酶抑制剂，而3种以上口服降糖药联合用药的比例也达16.1%；口服降糖药与其他药物联合使用情况看，配合使用抗高血压药的频率最高，其次是降脂药。

ABSTRACT : Objective To establish a HPLC method for determination of impurity dicyanodiamide and impurity(1) and impurity(2) in Metformin hydrochloride and Glibenclamide Tablets.

目的建立 HPLC 方法测定复方盐酸二甲双胍格列苯脲片中已知有关物质双氰胺杂质(1)和杂质(2)的含量。

The products produced throughout the year are :Chlopromazine Hydrochloride ;Metformin Hydrochloride ,Clozapine,Glipizide etc.in which Pheny butazone Metformin Hydrochloride and Clozapine have achieved the American FDA Certificate.

上海市医药股份有限公司第十五制药厂建于1931年，生产盐酸二甲双胍、格列吡嗪、氯氮平、保泰松、盐酸氯丙嗪等29个产品，其中，盐酸二甲双胍、氯氮平、保泰松这三个产品已通过美国FDA认证。

Metformin can inhibit the growth of lung adenocarcinoma cell lines significantly and potentiate cisplatin in a dose- and time-dependent manner in vitro. Cell-cycle progression is arrested in G1 stage and apoptosis is indued after metformin treatment.

二甲双胍可以使细胞周期循环阻滞于G1期，并诱导细胞的早期凋亡增加，从而有效抑制肺腺癌细胞株的体外增殖，其作用呈浓度及时间依赖性增强；二甲双胍与顺铂共同作用可以增强对肺腺癌细胞生长的抑制作用。

By the use of standard substance, a standard spectrum library was established for 10 drugs, metformin, ephedrine, pseudoephedrine, caffeine, phenformin, fenfluramine, indapamide, phenolphthalein, fluoxetine and sibutramine. The identification for illegally added drugs was performed by comparing the accordance of retention time and the three-grade mass spectrum with the standard spectrum library.

利用标准物质建立10种药物（二甲双胍、麻黄碱、伪麻黄碱、咖啡因、苯乙双胍、芬氟拉明、吲达帕胺、酚酞、氟西汀、西布曲明）标准谱库，通过与标准谱库保留时间和三级质谱图的比较对非法添加的药物进行定性鉴别。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。