二氯甲基苯

Two kinds of haptens 6-{[(2,3-Dihydro-2,2-Dimethyl-7-benzofuranyloxy)carbonyl] -amino}hexanoicAcidand4-{[(2,3-Dihydro-2,2-Dimethyl-7-benzofuranyloxy) carbonyl]-amino}butanoic Acid has been synthesized by chemical way.

本研究以2，3-二氢-2，2-二甲基-7-苯并呋喃氯甲酸酯为基础合成了克百威的两种半抗原，6—

For developing an immunoassay for multiple residues of pyrethroid pesticides, the hapten N-2- carbanmoyl-(3"-phenoxyphenyl) methyl 3-(2"-Cldoro-3",3",3"-trifluoropropenyl)-2, 2-dimethylcyclopropane- carboxylate was synthesized from cyanohydrin and 3-(2"-Chloro-3",3",3- trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylic acid via hydrolysis and esterification. The synthesis of the hapten was foundation of preparaing anti- cyhalothrin polyclonal antibodies.

为了制备对单一拟除虫菊酯高特异性的抗体，以菊酸和氰醇为起始原料，通过水解、酯化反应合成了半抗原N-2-氨甲酰-(3-苯氧基苄基)甲基-3-(2-氯-3，3，3-三氟丙烯基)-2，2-二甲基环丙烷羧酸酯，为进一步制备抗三氟氰菊酯的特异性抗体奠定基础。

The optimum conditions were reaction temperature 120°C, reaction time 20h, mole ratio of 5-chloromethyl-2-oxazolidinone and sodium phenolate 1:1. 3,5-Dimethylphenol and epichlorohydrin in sodium hydroxide were condensated to give l,2-epoxy-3-phenoxy propane, then the reation of l,2-epoxy-3-phenoxypropane and the carbamate afforded oxazolidinone in the yields of 69.0%~76.0%. The side reaction had been avoided effectively by the uses of the excessive epichlorohydrin and mixed catalysts.

用3，5-二甲基苯酚和环氧氯丙烷在氢氧化钠存在下缩合生成苯氧基环氧丙烷，然后和氨基甲酸酯反应生成噁唑烷酮，采用过量环氧氯丙烷和使用混合催化剂，有效的避免了副反应的发生，提高了噁唑烷酮的产率，产率69.0%～76.0%。

Project Background and Conditions: The company started research new chemical products in 1998. After two years of efforts, a series of pharmaceutical intermediate sulfathiazole leave instructions, including : 3- methyl sulfathiazole leave instructions, 2- sulfathiazole leave instructions ethanoic acid, 2- acetyl sulfathiazole leave instructions, 2-thiofuran amino ethane ,2-thiofuran acetic, 3,4,5- tighter nitrobenzene have been successfully developed. 2-thiofuran amino ethane are the precursors raw materials of series antibiotic analgesic.

二、项目建设背景及条件：1998年公司开始研究开发高新精细化工产品，经过两年的努力，已成功研制出噻吩系列医药中间体，包括：3-甲基噻吩、2-噻吩乙酸、2-乙酰噻吩、2-噻吩乙胺、2-噻吩乙醇、3，4，5-三氯硝基苯等。2-噻吩乙胺系列噻吩产品使用于血小板及血栓有关的心脏血管病及消炎镇痛等如氯吡格雷、兴孢噻吩钠、兴孢西丁、噻吩洛酸等十几种新药的前体原料，是国家政策鼓励发展和有自主知识产权的项目。

Anti-aging effects of non-lead and non-nickel antiager of 4,4 -Bis(alpha,alpha-dimethylbenzyl)diphenylamine(445)and 2-phenyl mercaptan parallelism imidazole were dealt with on the mechanical properties and vulcanizing performance of epichlorohydrin rubber.

研究了不含铅、镍重金属盐的防老剂445[4，4′-双(2，2-二甲基苄基)二苯胺]和2-硫醇基苯骈咪唑用于氯醚橡胶的防老化作用，考察了防老剂对ECO的力学性能和硫化特性等性能的影响。

For example, there is only local cooperative organization between polymer segments of atactic poly in the middle-sized solvent poly with molecular weight 200g/mol (PEG200). But for the stereo-regular isotactic polystyrene, pronounced content of 3〓 helix can be found in its middle-sized solvents.

例如，无规聚甲基丙烯酸甲酯在聚乙二醇（分子量为400）中分子溶剂中表现为链段的局部协同组织，而等规聚苯乙烯在邻苯二甲酸二辛酯、氯代十四烷等中分子溶剂中则出现相当含量的3〓螺旋构象。

The ultraviolet photosensitive initiating system is composed of 4,4"-bis(N,N"-dimethylamino) benzophenone, 2-chlorohexaarylbiimidazole and a hydrogen donor coinitiator n-dodecyl mercaptan.

用光敏剂4，4′-二(N，N′-二甲基-氨基)苯甲酮、引发剂邻氯代六芳基双咪唑和氢给体助引发剂十二烷基硫醇组成光敏引发体系。

In order to check the corresponding compound at 31P NMR –45.4 ppm, stable pentacoordinate spirobicyclic 2-phenoxy-1,3-phenylene-dioxo-1,3,2-iminoacetoxyphosphoranes were synthesized through a new and efficient method whereby phosphorus pentachloride was displaced stepwise by catechol, N,O-bisamino acid and phenol, or catechol, phenol and N,O-bisamino acid, their 31P NMR chemical shifts are at about 31P NMR –45.0 ppm, the results showed that the compound 4 at 31P NMR –45.4 ppm was pentacoordinate phosphorane containing amino acid residue.

采用磷谱跟踪来研究上述成肽反应机理。例如在氮气保护下，0.1mmol O，O-亚苯基磷酰氯（1）和0.15mmol N，O-二苯丙氨酸（2）苯溶液加入0.6ml核磁管中，混合均匀，反应过程用磷谱检测。反应1分钟后，起始原料1(δp=19ppm)很快转变成N-磷酰苯丙氨酸的三甲基硅基酯（3）(δp=19.8ppm)，在8分钟内，3完全转变成苯丙氨酸磷烷4(δp =-45.4ppm)，同时出现环磷三酯（6）(δp=3.5ppm)。随着反应的进行，对应于化合物4的峰逐渐变小，而6逐渐变大。

Because of its nonpoisonous, DMC can substitute phosgene , dimethyl sulfate or methylating used as methyl pharmaceutical to improve the security of production and reduce the environmental pollution; As the solvent, DMC can substitute fluorine lyons , methyl chloroform , trichloroethylene , benzene , dimethylbenzene, etc.. And it can be used as the paint dope, clean solvent. As gasoline additive, DMC can raise hard octane value and oxygen content and improve its antiknock possibility.

由于DMC无毒，可替代剧毒的光气、硫酸二甲酯等作为甲基化剂或羰基化剂使用，提高生产操作的安全性，降低环境污染；作为溶剂，DMC可替代氟里昂、三氯乙烷、三氯乙烯、苯、二甲苯等用于油漆涂料、清洁溶剂等；作为汽油添加剂，DMC可提高其辛烷值和含氧量，进而提高其抗爆性。

In addition, pesticides can also abnormal sperm, and lead to miscarriage, stillbirth, birth defects, such as benomyl, DBCP, methylmercury, such as epoxy heptachlor.

另外，农药也可使精子异常，而导致流产，死胎、新生儿缺陷，如苯菌灵、二溴氯丙烷、甲基汞、环氧七氯等。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。