二基取代了的

Eleven novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-oxadiazole derivatives (5) and six novel 2-alkylthio-5-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-5-yl)-1,3,4-thia- diazole derivatives (8) have been designed and synthesized by using 5-amino-3-ethoxycarbonyl-1H-1,2,4-triazole as a starting material.

以5-氨基－1H-1，2，4-三唑－3-羧酸乙酯为起始原料，设计合成了11个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-恶二唑类化合物(5)和6个新型的2-取代硫醚－5-（5，7-二甲基－1，2，4-三唑并[1，5-a]嘧啶基）-1，3，4-噻二唑类化合物(8)。

New compounds of the type of N--N'-(2,4-dichlorophenyloxyacetyl)-semicarbazides were synthesized by a series of reactions of preparing organic isocyanates by Curtius rearrangement with 2,4- dichloro aryloxyacetic acid hydrazide using one-pot procedures.

以芳香取代酸为原料，用Curtius重排的方法合成异氰酸酯，直接与2，4-二氯苯氧乙酰肼作用，一锅法合成了4种N-取代芳基-N'-(2，4-二氯苯氧乙酰基)氨基脲类化合物。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

A series of sulfanilamide group substituted derivatives were optimized on the basis of the semi-empirical quantum chemistry PM3 method.

以量子化学半经验PM3法对含磺胺基的一类有机化合物分子进行了几何构型优化，计算了分子的二阶非线性光学系数和电子转移，讨论了磺胺基在非线性光学材料设计中的特点和作用以及不同的取代基及取代位置对分子二阶非线性光学系数的影响

Using N, N-dimethyl-ethylenediamine as cationic substitute and 2-hydroxyethyl methacrylate or allylamine as co-substitute, a kind of pH-sensitive polyorganophosphazenes bearing unsaturated side group was prepared.

以N，N-二甲基乙二胺为阳离子型取代基，甲基丙烯酸羟乙酯或烯丙胺为共取代基，制备了同时带有pH响应性侧基和不饱和双键侧基的聚膦腈。

Replacement of one benzimidazole fragment with benzothiazole or benzoxazole and optimization of the structure to create the new frame of the compounds were also carried out with the exception to find more potent compounds. The purpose of design and synthesis of these compounds is to investigate the QSAR of this class of compounds with the inhibition of HCV NS3/NS4A protease and eventually to develop more potent inhibitors.

本文首次采用了丙二酰胺与邻芳二胺在微波辐射下制备对称性双芳并唑甲烷化合物、用芳并唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性双芳并唑甲烷化合物、用4-取代噻唑-2-乙酸乙酯与邻芳二胺在微波辐射下制备非对称性(4-取代-噻唑-2-基)(1H-芳并咪唑-2-基)甲烷化合物等合成路线，共合成了48个目标化合物，其中41个为新化合物，用~1HNMR，ESI-MS，FT-IR，元素分析对这些化合物进行了全面表征，确定了这些化合物的结构，并对部分化合物进行了~(13)CNMR分析。

A series of novel chiral aminophosphine ligands with binaphthyl backbone and partially reduced binaphthyl backbone were synthesized from optically pure NOBIN and H〓-NOBIN respectively. The effects of binaphthyl backbone and substitutes at the phosphorous atom on Pd (0)-catalyzed allylation of racemic 1, 3-dipheylprop-2-en-1-yl acetate with dimethyl malonate were systematically investigated.

从NOBIN出发合成了一系列膦上含有不同取代基的氮膦配体MAPs以及含有被部分还原的联萘骨架的氮膦配体H〓-MAPs，将此两类配体运用于钯催化的乙酸1，3-二苯基烯丙基酯与丙二酸二甲酯的反应中，考查了膦上取代基和配体骨架对反应的影响。

The mechanisms of intramolecular biaryl nonphenolic coupling were explored by reactions of different 1,4-biaryl substituted butanes with DDQ in TFA.

通过对含不同取代基的芳环化合物、1，4-二芳基丁烷链上含不同取代基化合物与DDQ在TFA中进行非酚氧化偶合和重排反应的研究，对分子内的二芳基非酚氧化偶合反应机理作了深刻的探讨。

By the nucleophilic substitution reaction of 6-O-tosyl-l,2:3,4-di-O- isopropylidene-a-Z-galactopyranose (3) with some substituted 1, 2,4- triazole-3-thiols (4a ~ 4c) or 1, 2, 3,4-tetrazole-5-thiols (5a~5f), nine 6-S-(substituted triazolyl or tetrazolyl)-l,2 : 3,4-di-O- isopropylidene-a-D-galactopyranoses (6a ~ 6i) were prepared in high yields. Their structures and configurations were analyzed and established by elemental analysis, IR, NMR, MS spectra.

报道了6－O－对甲苯磺酰基－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖（3）与取代的3－巯基三唑或5－巯基四唑4a-4c或5a-5f的亲核取代反应，合成了9个6－S－－1，2：3，4－二－O－异亚丙基－α- D吡喃型半乳糖（6a-6i），通过元素分析，IR，NMR和MS确证了上述化合物的结构，并经分子模型计算进行了其构象分析。

To estimate the bioconcentration factor of benzene derivatives in fish by gas chromatography retention time, this paper measured the BCF of chlorobenzene, o-chloro-toluene, p-dichlorobenzene, m-dichlorobenzene, 1,2-dichlorobenzene, nitrobenzene, p-chloro-aniline, p-chloro-nitrobenzene, and 4-chlorodiphenyl in grass crap, and the t_R of test derivatives on the stationary phases of six kinds polarity.

为了用气相色谱保留时间估算取代苯类化合物在鱼体内的生物富集系数，测定了草鱼对氯苯、邻氯甲苯、对二氯苯、间二氯苯、邻二氯苯、硝基苯、对氯苯胺、对硝基氯苯、4-氯联苯9种取代苯类化合物的BCF和不同取代苯化合物在6种不同极性固定相上的tR，建立了tR与BCF的一元回归方程及tR一阶分子连接性指数(1XV)与BCF的二元回归估算方程。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。