乳酸

The stability test showed that the 4ac-PLA-NP lyophilize injection was stable without obvious changes in morphology, particle size, pH, drug loading, entrapment efficiency in 4～25℃ after storage for 3 month.

4ac-聚乳酸-纳米粒（4ac-PLA-NP）冻干针剂经常规稳定性考察，各项指标均未发生明显变化，临界相对湿度约为73％。

The drug release experiments in vitro indicated that with the increase of PLA molecular weight, the drug release rates decreased. 4ac releasing from 4ac-PLA-NP could be characterized by Weibull's equation. The interaction between 4ac and others compositions was not detected by DSC. The peak position of 4ac in DSC did not changed comparing 4ac with 4ac-PLA-NP lyophilize injection. Thc X-ray result showed that the peak of 4ac-PLA-NP was piled up between 4ac and other compositions.

差示扫描量热分析结果表明药物与各组分之间无明显的相互作用，制成4ac-PLA-NP冻干针剂后，其放热峰主要表现为聚乳酸的放热峰：X-射线衍射结果表明药物与载体间无相互作用，4ac-PLA-NP主要表现为4ac与载体之间的叠加峰；TLC、FT-IR也同样表明药物与载体无相互作用，它们之间是一种物理结合，并未有新物质生成。

Objective To analyze clinical characteristics of 3 cases of MELAS syndrome that misdiagnosed as hepers simplex virus encephalitis.

目的 分析误诊为单纯病毒性脑炎的3例线粒体脑肌病伴乳酸血症和卒中样发作的原因。

Objective To analyze clinical characteristics of 8 cases of MELAS syndrome that misdiagnosed as herpes simplex virus encephalitis.

目的分析误诊为单纯疱疹病毒性脑炎的8例线粒体脑肌病伴乳酸血症和卒中样发作综合征的临床特征。

Objective To study the characteristics of clinical manifestations,laboratory examinations and molecular genetics in MELAS syndrome.

目的 探讨线粒体脑病伴乳酸酸中毒和卒中样发作综合征临床及分子遗传学特点。

A clinical diagnosis of MELAS was made.

血乳酸和丙酮酸水平升高，临床诊断MELAS。

Methods: Fifteen cases were divided according to their clinical characteristics: 7 cases of MELAS, 4 cases of pure mitochondrial myopathy, and 4 cases of CPEO.

线粒体病患者15例，根据临床表现分为3组，线粒体脑肌病伴高乳酸血症、卒中样发作组7例，单纯型线粒体肌病组4例，慢性进行性眼外肌麻痹组4例。

The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.

本结果指明艾地苯醌改善了患者大脑线粒体的氧化代谢，同时並提示艾地苯醌具有治疗MELAS（线粒体脑肌病伴高乳酸血症和卒中样发作）的潜在效应。

We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10, increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET.

我们报告了一例36岁患MELAS（线粒体脑肌病伴高乳酸血症和卒中样发作）的患者，在口服一种辅酶Q10衍生物艾地苯醌后，显著地增加了氧气和氧提取部分的比例而同时不增加患PET症的患者的脑血流量。

The symptoms of CNSV patients included headache,limbs weakness,and erythrocyte sedimentation rate increase.The symptoms of MELAS patients included epilepsy and increased serum lactic acid.

CNSV临床表现以头痛、肢体无力及变态反应改变为主；线粒体脑肌病以癫发作、血清乳酸升高为主要特点。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。