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乳腺癌

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The isoform hMAM cDNA consisting of 270 bp, was different from the wild type one of 279 bp due to nine continuous base pair missing. Therefore the translational product of the isoform was seen to be lack of three continuous amino acid (-79~-81, VFM) compared with that of the wild type. The homology of the wild type and the isoform are testified to be 96% in both DNA and amino acid sequences.

乳腺癌组织和乳腺癌细胞株中发现两种hMAM cDNA亚型:hMAM和hMAM,长度分别为279和270bp,二者相差9个连续碱基,其翻译产物相差3个连续氨基酸残基(-79~-81,VFM),二者基因和氨基酸序列匹配度均为96%。cDNA片段分别插入原核表达质粒pGEX-KG,构建的质粒命名为pGEX-KG/hMAM和pGEX-KG/hMAM。

The PCR-SSP test which was used to detect the AY751490 homozygote has an important significance for the early diagnosis and risk assessment of breast cancer.

应用PCR-SSP技术检测该单倍型纯合子对于乳腺癌患病风险评估及早期诊断具有重要意义,上述研究结果为乳腺癌普查提供了实验基础和理论依据。

BackgroundBreast cancer bone metastasis which occupy 70% of the distant metastasis is one of the most common clinical disease. It can cause hypercalcemia, focal baryodynia, pathologic fracture and so on.

乳腺癌骨转移占乳腺癌远处转移的70%,是临床上一种常见的严重疾病,可引起高血钙症、局灶性剧痛及病理性骨折。

Objective To study the significance of expression of cyclooxygenase-2(COX-2)and vascular endothelial growth factorin breast cancerand its correlation.Methods Paraffin imbedding tissues from 60 cases with BC were detected for expression of COX-2 and VEGF by immunohistochemistry,the relationship of its expression with clinical pathological parameters were analyzed.

目的 探讨环氧化酶-2(COX-2)和血管内皮细胞生长因子在乳腺癌组织中的表达及其表达之间的关系方法 S-P免疫组织化学方法检测60例乳腺癌石蜡包埋组织中COX-2和VEGF的表达,分析其表达之间的关系及其与临床病理参的关系。

It is not only inhibited recurrence of breast cancer, but also reduced incidence of the opposite site malignancy.

它不仅能抑制乳腺癌的复发,还能降低对侧原发乳腺癌的发生。

Objective To investigate the expression of inhibitor of apoptosis protein survivin and determine its role in carcinogenesis and progression in breast cancer.

目的:检测凋亡抑制蛋白survivin在人乳腺癌中的表达,进一步探讨其在乳腺癌发生发展中的作用。

Abstract] Objective To inquire into the action of the direct and indirect signs of breast cancer.

摘要] 目的探讨乳腺癌X线的直接征象和间接征象在乳腺癌诊断中的作用。

Methods :A retrospectively analysis of pirh 2 mRNA expression in 87 cases of stage I and II breast cancer, 27 cases of stage III and IV breast cancer was made, and 10 cases of fibroma tissue and 6 cases of normal lacteal gland tissue as control, all of which were from Department of Breast Surgery, XiangYa Hospital in recent 10 years.

回顾性分析湘雅医院乳腺科近10年间收治的乳腺肿瘤患者的临床资料,其中包括I,II期乳腺癌87例,III,IV期乳腺癌27例Pirh2mRNA的表达,并以纤维瘤组织10例和正常乳腺组织6例作为对照。

Methods level of telomerase activation and PCNA expression were detected in 80 cases of breast cancer,36 cases of side-cancer tissues and 10 cases of lacteal gland benign lesion using TRAP-PCR-ELISA and S-P immunohistochemistry technique.

采用端粒重复序列扩增聚合酶链反应-酶联免疫吸附测定法(TRAP-PCR-ELISA)和免疫组织化学链霉素生物蛋白过氧化物酶法对80例乳腺癌组织、36例乳腺癌相应癌旁组织和10例乳腺良性病变的端粒酶活性及增殖细胞核抗原进行检测。

Methods The level of telomerase activation and PCNA expression were detected in 80 cases of breast cancer,36 cases of side-cancer tissues and 10 cases of lacteal gland benign lesion using TRAP-PCR-ELISA and S-P immunohistochemistry technique.

采用端粒重复序列扩增聚合酶链反应-酶联免疫吸附测定法(TRAP-PCR-ELISA)和免疫组织化学链霉素生物蛋白过氧化物酶法对80例乳腺癌组织、36例乳腺癌相应癌旁组织和10例乳腺良性病变的端粒酶活性及增殖细胞核抗原进行检测。

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