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乳腺癌

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"We had no inkling that these genes had anything to do with breast cancer," said Easton.

伊顿说,"我们起初并没想到这些基因会与乳腺癌有关"。

"As more genes are identified, tests will become more predictie," said Easton.

伊顿说,"随着越来越多的基因得到鉴定,乳腺癌检测的结果将会告诉我们越来越多的东西。"

In this paper, a new medical impedance imaging modality (Magnetic resonance electrical impedance tomography-MREIT) is first introduced, including its mathematical theories and the reconstruction algorithms. Then its application in early breast cancer detection research is introduced in detail. Finally, its future research direction and major problems are summarized.

本文在此前提下介绍了一种高分辨率的医学电阻抗成像技术-磁共振电阻抗成像技术的成像原理与成像算法,然后介绍了MREIT技术在早期乳腺癌检测方向的应用,最后分析了该研究方向的发展前景以及目前存在的问题。

However, whether it is useful in the assessment of the prognosis of breast cancer is still elusive.

目的:探讨抗凋亡基因bag-1在乳腺癌组织中的表达及与预后的关系。

Methods Microsatellite instable-high colon cancer cell line HCT116, microsatellite stable colon cancer cell line HT29, as well as control MSS breast cancer cell lines were treated by NMD inhibition drug emetine and actinomycin D.

方法采用NMD抑制药物emetine联合actinomycinD,分别处理高度微卫星不稳定型大肠癌细胞株HCT116和微卫星稳定的大肠癌细胞株HT29,以及对照的MSS乳腺癌细胞株,以全基因组cDNA芯片检测经药物处理和不经药物处理的细胞株的mRNA表达变化。

Immunohistochemical analysis of the expression of CDK4 and P16 in human endometrioia type endo metrial cacionoma[J].

MMP 2,MMP 9和Ⅳ型胶原在乳腺癌中的表达及其意义[J]。

Five models were used to investigate the "Changdong"" s anti-tumor effect: mice S180 sarcoma solid model, mice liver cancer H22 solid model, mice Lewis lung cancer model, as well as human liver cancer QGY and colon cancer LOVO implanted in naked mice; mice liver cancer H22 was also used to evaluate the enhancive effect of "Changdong" when it was co-applied with other anti-tumor agent or with radiotherapy; The "Changdong"" s cytotoxic effect in vitro on such tumors as QGY, LOVO, lung cancer A549, breast cancer MCF-7, as well as mice leukemia P388 was observed through MTT method. And investigate the effect of "Changdong" on proliferation of spleen lymphocyte, on activity of NK cell and on synthesis of IL-2 in mice bearing Lewis lung cancer, respectively. With propidium iodide straining, cell aigptosis and cell circle were analyzed by flow cytometry. Result:"Changdong" has an evident tumor inhibitive effect on mice tumor model as well as human tumor implanted in naked mice with a quantity-effect relationship.

使用小鼠S180肉瘤、小鼠肝癌H22实体瘤和小鼠Lewis肺癌模型,以及人体肝癌QGY和人体肠癌LOVO裸鼠异种移植模型,进行"长动"的抗肿瘤药效学研究:用小鼠肝癌H22进行"长动"合并放疗和化疗的增效作用研究;用MTT法进行"长动"对肝癌QGY、肠癌LOVO、肺癌A549、乳腺癌MCF-7、小鼠白血病P388等10株人体和动物肿瘤细胞的体外细胞毒性作用研究;用淋巴细胞转化试验、小鼠NK细胞活性试验、小鼠胸腺细胞增殖法分别测定"长动"对荷Lewis肺癌小鼠的脾淋巴细胞增殖的影响、自然杀伤细胞活性的影响和对小鼠产生白介素-2(IL-2)的影响;用流式细胞仪PI单染色法进行"长动"对人体肝癌QGY细胞的体外诱导凋亡作用和对肿瘤细胞周期的影响的研究。

Methods SLN of 40 patients with breast cancer were performed histological analysis by hematoxylin and eosin staining, and the expression level of CK 19 in these nodes were determined by quantitative RT-PCR.

目的 探讨定量RT-PCR法检测细胞角蛋白(CK19)在乳腺癌前哨淋巴结中的表达,提高前哨淋巴结活检中微转移的检出率。

Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis [J]. Mol Cancer Res, 2002,1(1):2-11[4] Carles-Kinch K, Kilpatrick KE,Stewart JC,et al.

研究表明,EphA2与其配体EphrinAl可高表达于许多恶性肿瘤组织中,包括乳腺癌、结肠癌、食管癌及前列腺癌[6,7]等,但在原发性肝细胞癌中,EphA2与其配体的表达情况及其与临床病理特征的关系还不十分清楚。

During this group patient is changing cure, 1.2 harmful response all differ of degree have the whole body difference of lack of power, accept, epigastrium bilges frowzily feeling, have among them constipation and / or defecate secret person 97, occupy 38.8%, gastric bowel path reacts person 79, occupy 31.7%, the person that marrow is restrained 31, occupy 12.4%, oral cavity ulcer person 18, occupy 0.7%. 2 before changing cure, nurse 2.1 elaborate psychology nurse, eliminate patient of mental obstacle old age to have in all many sided such as nerve, physiology, thinking not at patient of other age group, together with is mixed to the fear of cancer distressed mood, cause very easily angst and / or depressed mental state.

其中食管癌173例(术后138例),贲门癌42例(术后27例),乳腺癌16例,肺癌11例(非小细胞型肺癌3例),非柯杰金氏淋巴瘤7例。1.2不良反应本组患者在化疗期间均不同程度的有周身乏力、纳差、上腹部闷胀感,其中有便秘和/或大便秘者97例,占38.8%,胃肠道反应者79例,占31.7%,骨髓抑制者31例,占12.4%,口腔溃疡者18例,占0.7%。2化疗前护理2.1精心心理护理,消除精神障碍老年患者在神经、生理、思维等诸多方面有别于其它年龄组患者,加之对癌症的惧怕和忧伤情绪,很易引发焦虑和/或抑郁的心境。

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