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objective to optimize the formulation of methimazole loaded polylactic co glycolic acid microspheres.

目的 优化甲巯咪唑聚乳酸羟基乙酸共聚物微球的处方工艺。

The pegylated polylactide-poly glycolide nanoparticle, whose surface was co-modified withmaleimide-polyethylene glycol and methoxy-polyethylene glycol, was made by double-emulsion and solvent evaporation method andcovalently conjugated with thiolated lactoferrin via its maleimide functionalgroup.

第一章首先由复乳/溶媒蒸发法制备马来酰亚胺—聚乙二醇(Maleimide-PEG,MAL-PEG)和甲氧基聚乙二醇表面共修饰的聚乳酸-聚羟基乙酸纳米粒,然后通过其表面MAL-PEG与巯基化Lf共价连接而制备Lf-NP_。

The hypha growth-inhibiting method and the virulence determination method were used to investigate the inhibition effects of the petroleum ether fraction, chloroform fraction, ethyl acetate fraction, n-butanol fraction and water fraction in the alcoholic extracts from the aboveground of Peganum harmala L.

采用抑制菌丝生长法和毒力测定法,研究了骆驼蓬地上部醇提物的石油醚、氯仿、乙酸乙酯、正丁醇和水5个极性部位对南瓜枯萎病菌、西瓜枯萎病菌Fusarium oxysporum f。

An unambiguous assignment of the main 1H NMR resonance of nylon 6 in trifluoroacetic acid solution was carried out by using a combination of 1D and 2D NMR heteronuclear technique.

采用ID和2D NMR技术,归属了三氟乙酸溶液中尼龙6链上的主要1H NMR共振信号。

The molecular sieve is prepared in the steps: at the room temperature, hexadecyl trimethyl ammonium bromide is mixed and dissolved with the sodium hydroxide, and is added with TEOS in dropping way, and simultaneously added with Me metal salt water solution and lanthanum nitrate solution in dropping way; the pH value of the mixed solution is adjusted by acetic acid to be 10 to 11, and is mixed for 1 to 2 hours after being stabilized; the sol is moved into a polyfluortetraethylene bottle to be heated and crystallized for 2 days in the oven at the temperature of 100 DEG C; after filtering, washing and drying for nights, and being calcined in a muffle at the temperature of 550 DEG C for 3 to 7 hours, the dual-metal-atom improved MCM-41 mesoporous molecular sieve is obtained.

该分子筛的制备为室温下,将十六烷基三甲基溴化铵和氢氧化钠混合溶解,搅拌并滴加入TEOS,同时滴加入Me金属盐水溶液和硝酸镧溶液并搅拌,用乙酸调节pH值至10~11,稳定后搅拌1~2小时,溶胶转入聚四氟乙烯瓶中在100℃下烘箱水热晶化2天,经过滤、洗涤、干燥过夜,马弗炉550℃焙烧3-7h,得双金属原子改性MCM-41介孔分子筛产品。

Then the protected D-mannitol, mixed with lead tetraacetate, hippuric and acetic anhydride, were refluxed in THF for 18 h in a one-pot two step reaction to afford a chiral precursor-2-phenyl-4-[-2,3-O-]-propylidene-5(4H)-oxazolones.

产物与四乙酸铅、马尿酸、乙酐于THF中回流18 h完成一釜二步反应,纯化后得到含有手性碳原子的环丙烷氨基酸前体-2 苯基-4-[-2,3-O-]丙叉?

MAIN OUTCOME MEASURES: The contents of monoamine neurotranmitters of norepinephrine, adrenalin, dopamine and 5-serotonin (5-HA) and its metabolites of DHPR, 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid in the striatum and marginal area of brain in rats were observed.

主要观察指标:大鼠纹状体和脑边缘区单胺类递质去甲肾上腺素、肾上腺素、多巴胺和5-羟色胺及其代谢产物3,4-二羟苯乙二醇、5-羟吲哚乙酸、高香草酸的含量。

MAIN OUTCOME MEASURES: Content of monoamine transmitter such as levarterenol, adnephrin, dopamine, indoleacetic acid, homovanillic acid and 5-serotonin.

主要观察指标:测定各组大鼠脑组织单胺类神经递质去甲肾上腺素、肾上腺素、多巴胺、吲哚乙酸、高香草酸和5-羟色胺的含量,并进行组间对比。

Methods The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 7-nitroindazole (7-NI) on nitric oxide synthase activity, levels of dopamine、3,4-dihydroxyphenylacetic acid、homovanillic acid, and TH-immunostained postive nerve fibres in the striatum of mice were determined by using colorimetic analysis, HPLC with electrochemical detection, and immunohistochemical analysis.

用比色分析、高效液相色谱电化学及免疫组化法检测1-甲基-4-苯基-四氢吡啶和7-硝基吲唑(7-NI)对C57BL小鼠纹状体一氧化氮合酶活性,多巴胺、二羟基苯乙酸、高香草酸水平和酪氨酸羟化酶免疫阳性神经纤维的影响。

The new finding of this research is that PA has a regulative effect on the expression of C-myc, P16 and Hox genes.

苯乙酸对C-myc,p16,HOX基因表达调节作用,是本研究的新发现。

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