乙酰甲基

The decarboxylation of 5-hydroxymethylfurfural to levulinic acid is a key step in the preparation of levulinic acid from biomass.

5-羟甲基糠醛脱羧生成乙酰丙酸是生物质资源出发制备乙酰丙酸过程中的关键步骤之一。

The types of histone methyltransferases, the relationship between methylation of Lysine 9 of H3 and the formation of heterochromatin, gene regulation in euchromatin, and that with DNA methylation, were mainly introduced.

主要阐述了组蛋白甲基转移酶的类型，组蛋白H3中第9位赖氨酸甲基化与异染色质的形成、常染色体中基因表达的调控，以及与DNA甲基化之间的关系，说明了组蛋白甲基化与组蛋白乙酰化、磷酸化的相互关系，指出组蛋白甲基化对维持细胞各种状态的平衡起到极其重要的作用。

The condensation of aromatic aldehydes with active methylene compounds like malononitrile, cyanoacetamide and ethyl cyanoacetate has been found to proceed very efficiently at room temperature giving excellent yields, but the condensation of heteroaromatic,α,β-unsaturated and aliphatic aldehydes with active methylene compounds proceeded smoothly in 50~65℃ with good yields and the reactions of aromatic, aliphatic ketones as well as p-phthalaldehyde with malononitrile also proceeded in 75~85℃ with moderate yields.

芳香醛与活泼亚甲基化合物如丙二腈、氰基乙酸乙酯、氰基乙酰胺的缩合在室温下即能顺利进行，获得了很高的收率；而对于杂环芳醛、α，β-不饱和的醛以及脂肪醛与活泼亚甲基化合物的缩合，需在50~65℃下进行，也取得了很高的收率；对于脂肪酮、芳香酮以及二元醛与丙二腈的缩合在75~85℃下也能顺利地进行，获得中等以上的收率。

Chapter 2 has analysized the conversly synthetic means of solanesol and designed novelly synthetic routes of solanesol and key intermediate Chapter 3 has summarized the preparation of trans-3-methyl-4-hydroxy (bromo-2-butenyl oxy methyl benzene In chapter 4 ,a novel technology of important intermediate(all trans-8-bromo geranyl acetate),which is suitable for industrial procedure , was found .meanwhile,an another new way has been invented ,of which the key intermediate (all trans-8-hydroxy geranyl acetate) has been produced.

第二部分分析了茄尼醇的逆合成方法，设计了一条适合于合成茄尼醇的合成路线及其重要中间体的合成路线。第三部分研究了重要中间体[Trans-3-甲基-4-羟基-2-丁烯基乙酰基(苄基，2，3-二氢吡喃基)醚]的合成新方法，找到了一条适合于工业化生产的制备反式-3-甲基-4-羟基-2-丁烯基苄基醚的新方法。第四部分研究了重要中间体[-3，7-二甲基-8-羟基-2，6-辛二烯-1-醇乙酸酯、-3，7-二甲基-8-溴-2，6-辛二烯-1-醇乙酸酯]的合成新方法，找到了一条适合于工业化生产的制备它们的新方法；同时研究了一条制备-3，7-二甲基-8-羟基-2，6-辛二烯-1-醇乙酸酯的另一新方法。

Starting with commercial available tosylmethyl isocyanide and but-2-enoic methyl ester, pyrrolo[2,1-f][1,2,4]triazine derivatives was prepared by twelve-steps process in total yiled of 5.0%~8% via pyrrole and pyrrolo [2,1-f] [1,2,4] triazine ring formation, substitution and amination reactions etc.

本文以简单的对甲基苯磺酰甲基乙腈和反-2-丁烯酸为原料，经过形成吡咯，吡咯并[2，1-f][1，2，4] 三嗪环，取代，酰胺化等等12步反应，合成了结构新颖的吡咯并[2，1-f][1，2，4] 三嗪衍生物，总收率达5%～8%。

Deoxybenzoin(3) was prepareded by using the resorcinol and substituted phenylacetic as starting meterials in microwave-mediated.Then the compound(3) was reacted with acetic anhydride to produce(4).The compound(4) was hydrolyzed to convert compound(5) in the acid-mediated. The compound(5) was reacted with the 1,2-dibromo-ethane and 1,3-dibromo-propane in refluxed condition with acetone as solvent to give(6) or(7),respectively.Lastly,the title compounds were synthesized by refluxing(6) or(7) with 2-methyl-benzimidazole and potassium carbonate in acetone solution.

以取代苯乙酸和间苯二酚为起始原料，用微波辐射法合成脱氧安息香(3)，(3)与乙酸酐缩合生成2-甲基-7-乙酰氧基异黄酮(4)，(4)在酸性条件下水解生成相应的异黄酮(5)，化合物(5)分别与1，2-二溴乙烷和1，3-二溴丙烷反应生成(6)和(7)，化合物(6)和(7)再分别与2-甲基苯并咪唑偶合生成目标化合物。

Two novel pyrazolone derivatives 2-ethylamino-6H-5-(1-phenyl-3-methyl/phenyl-5-pyrazolone-4-ylene)-1,3,4-thiadiazine (PMCP-ETSC/DPCP-ETSC) containing NNS six-membered heterocycles were synthesized by the condensation reaction of 1-phenyl-3-methyl/phenyl-4-chloroacetyl-pyrazolone-5 with 4-ethyithiosemicarbazide. The title compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and single-crystal X-ray diffraction.

利用1-苯基－3-甲基／苯基－4-氯乙酰基－吡唑啉酮－5与4-乙基氨基硫脲发生缩合反应，生成了2个新的双杂环化合物2-乙氨基－6H-5-（1-苯基－3-甲基／苯基－5-吡唑啉酮－4-基）－1，3，4-噻二嗪(PMCP-ETSC/DPCP-ETSC)，并对其进行元素分析、红外光谱、核磁共振表征和晶体结构分析。

Could keep above 95% in the fixed beds. In order to achieve high stereo-selectivity with yeast, ethyl acetoacetate was used as the model substrate,and a novel approach was proposed to selectively inhibit R-enzymes in yeast before reaction.

以乙酰乙酸乙酯为模型底物，以丙烯酸、乙醚、二甲基亚砜、丙烯酰胺、正己烷等有机溶剂选择性地抑制酵母中R型酶，提高反应立体选择性。

Synthesis 3,5-dihydroxytoluene by ethyl acetoacetate and diketene as material(yield 6%),by 3-methyl-4-chlorophenol and KOH as material(yield 30-40%)respectively,It was solved for product separation and purify.

分别以乙酰乙酸乙酯与双乙烯酮为原料(收率6%)、3-甲基-4-氯苯酚与氢氧化钾为原料(收率30-40%)合成了3，5-二羟基甲苯，解决了产品分离纯化问题。3-甲基-4-氯苯酚路线进行了中试，中试收率为20%。

The invention adopts halogen acetylized crosslinked polystyrene resin and hydroxybenzyl alcohol as the raw material, and the solid phase synthesis carrier with hydroxymethyl as the active group is synthesized through the joint catalysis of N, N-dimethyl formamide used as the reaction solvent, inorganic base and phase-transfer catalyst.

本发明采用卤乙酰化交联聚苯乙烯树脂和对羟基苯甲醇为原料，在以N，N-二甲基甲酰胺为反应溶剂、无机碱及相转移催化剂的共同催化下合成了一种以羟甲基为活性基团的固相合成载体。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。