乙酰水杨酸

Eidence Acquisition A systematic reiew of the English-language literature was undertaken using MEDLINE and EMBASE (searched through February 2007) and the search term aspirin or acetylsalicylic acid and dose.

证据获取：对MEDLINE和EMBASE数据库（2007年2月检索）中以阿司匹林或乙酰水杨酸及剂量为检索词的英文文献进行系统评价。

Methods Barbiturate drugs in blood were extracted with organic solvent and detected by LC-MS/MS with aspirin internal standard.

方法血液中的巴比妥类药物用有机溶剂液-液萃取，以乙酰水杨酸为内标，LC-MS/MS测定。

Aspirin is usually used to treat fever heat, headache, neuralgia , rheumatoid arthritis etc.

乙酰水杨酸是老药新用的典型代表，100年以来其在发热、头痛、神经痛、类风湿性关节炎等疾病方面的疗效愈来愈被人们认可。

The ancient Greeks, for example, treated pain with a tea made by boiling willow leaves and bark, a tea modern scientists now know contains salicin, a precursor of acetylsalicylic acid—aspirin.

例如，古希腊人用柳叶和柳树皮煮成的茶水来止痛。现代科学家已经了解到，这种茶里面含有水杨苷成分，就是乙酰水杨酸——阿司匹林的前身。

Acetosalicylic acid could stabilize the structure and function of the membrane and accordingly promote the growth of aquatic plants.

而乙酰水杨酸能在一定程度上稳定膜的结构和功能，对水生植物的生长有一定的促进作用。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

Silicotungstic acid ; acetylsalicylic acid ; catalysis ; synthesis

乙酰水杨酸； SiW12/C ；催化；合成

The χ2 test has been used to evaluate the statistical difference in aspirin taste-blindness ratio between male and female,the result showed that there was no significant difference (P＞0.90),and the gene determining for aspirin tasting ability located on autosomes.

经χ2检验，男、女性的味盲率无显著差异（P＞0.90），表明决定乙酰水杨酸尝味能力的基因位于常染色体，对该基因的显隐性等特点尚需通过家系分析进行确定。

Thrombocytopenia: antineoplastic agents, sulfa drugs, streptomycin, isoniazid, estrogen, phenytoin, methyldopa, hydrochlorothiazide, acetyl salicylic acid, rifampicin, phenylbutazone, heparin, Kui Nitin, etc. can cause.

血小板减少症：抗肿瘤药物、磺胺类药物、链霉素、异烟肼、雌激素、苯妥英钠、甲基多巴、氢氯噻嗪、乙酰水杨酸、利福平、保泰松、肝素、奎尼丁等都可引起。

In the present study, we report a synergistic interaction between acetylsalicylic acid and caffeine on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti-inflammatory effects and peripheral prostaglandin E2 (PGE-2) synthesis inhibition.

在大鼠的周围炎症模型中，发现乙酰水杨酸和咖啡因交互作用抑制伤害性刺激。相反，没有发现抗炎药与外周前列腺素E2(PGE-2)合成抑制有交互作用。

I will endeavour to find you some assistance.

我尽力帮你找人帮忙。

At first I only know bruck is the idol of American younglings, afterwards I returned back to Taiwan ,even in Beijing last year ,I saw her poster everywhere, I was so surprised at her charm.

起初我只晓得布鲁克雷德丝是美国少男少女崇拜的偶像，后来回台湾，甚至去年在北京，居然也四处看见她的海报，才惊讶她的魅力之大。