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Histone acetylation and deacetylation can regulate many chromosome functions, such as gene expression and chromosome segregation.

组蛋白乙酰化和去乙酰化可调节染色体的多种功能,例如基因表达和染色体分离等。

Histone acetylation and deacetylation are the most common forms involved in chromatin modification, which participate in gene transcription regulation.

组蛋白乙酰化和去乙酰化是染色质修饰中最为常见调节方式,参与基因的转录调控。

BMI-1(B-cell-specific Moloney murine leukemia virus integration site 1), a Polycomb group repressor, is always present as a PcG complex combined with RING1, HPC2, Mph2, et al. BMI-1 prolongs cells'capacity to proliferate and represses their senescence by repressing the transcription of CDKN2A through acetylhydrolasing or deacetylhydrolasing the Polycomb response elements in chromosome.

BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1)属于PcG家族,它与该家族其他成员如RING1,HPC2,Mph2等结合形成蛋白复合体,作用于染色质PREs位点,通过对组蛋白进行乙酰化和去乙酰化修饰,从而稳定抑制CDKN2A转录,最终促进细胞的增殖并抑制细胞凋亡。

The use ofβ-cyclodextrin can make oximation of acetylacetone happened without sulfuric acid and at high temperature.

9使用环糊精催化乙酰丙酮肟化反应,可在不使用硫酸,较高温度下实现乙酰丙酮的肟化反应。

The use ofβ-cyclodextrin can make oximation of acetylacetone happened without sulfuric acid and at high temperature.

使用环糊精催化乙酰丙酮肟化反应,可在不使用硫酸、高温下实现乙酰丙酮的肟化。

The patients with rheumatoid arthritis with the slow NAT2 acetylator genotypes have been shown to have more side effects than fast acetylator genotypes when taking SASP.

同时也有研究发现慢型乙酰化表型的风湿性关节炎患者在服用SASP后,与快型乙酰化表型患者相比,副反应发生率明显升高。

This study was based on the soy protein isolates as raw materials. Chemical modification( acetylation,succinylation ,phosphorylation and urea modification) of SPI were used to improve adhesive strength and water resistance of SPI-based plywood adhesives. Then two modified ways combined were applied to SPI and their adhesive properties were studied. This research also characterized the thermal and adhesive properties of two major soy protein components 7S conglycinin and 11S glycinin after urea modification. Finally, the mechanism of improving SPI's adhesive properties was preliminarily discussed.

本文是以大豆分离蛋白为原料,进行SPI的化学修饰以提高其胶粘特性;采用了磷酸化试剂三聚磷酸钠、乙酰化试剂乙酸酐、琥珀酰化试剂琥珀酸酐和有机溶剂尿素修饰和变性SPI,研究修饰和变性后的SPI作为木材胶粘剂的胶粘性与耐水性,同时研究了两种方法复合修饰SPI对其粘度、胶粘强度和耐水性的影响;然后以SPI为原料,进行7S和11S球蛋白的提取以及胶粘特性的研究,对SPI起胶粘特性的机理进行了初步探讨。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin,TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制,利用Westernblot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21WAF1表达量的改变。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin, TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制,利用Western blot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21(上标 WAF1)表达量的改变。

The improved method of konjac glucomannan carboxy methylation was proposed in this paper according to the effects of deacetylation. Carboxymethyl KGM were synthesized by blending KGM with etherification agent first and then basifying and catalyzing in ethanol. Basifying first and then etherifying prepared traditional carboxymethyl KGM.

针对脱乙酰基的这种影响进行羧甲基化方法的改进,在乙醇介质中先混合醚化剂,再进行碱化催化反应制备羧甲基魔芋葡甘聚糖,并通过与传统的先碱化再醚化的KGM羧甲基改性方法比较,达到乙酰基脱出顺序上的不同。

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