乙酰化的

The immunoregulation activity of SPG-1 mainly existed in the part of sugar chain, but keeping its molecular structure intact had some effects on its immunoregulation activity; SPG sulphation had reducing effects on the immunoregulation of SPG-1, whereas, after medium and low acetification of SPG, the immunoregulation of SPG was enhanced. Conversely after high acetification, the immunoregulation of SPG-1 decreased, that is, after introducing sulfuric and acetic acid base in SPG-1, its immunoregulation changed. All of these indicated the structure of SPG-1 was closely connected with its immune activity.⑤.

甘薯糖蛋白SPG-1的免疫调节活性主要在其糖链部分，但保持分子结构的完整性对其免疫调节的活性有一定的作用；甘薯糖蛋白硫酸化对甘薯糖蛋白SPG-1的免疫调节有降低作用，而中、低度乙酰化后，可提高甘薯糖蛋白的免疫调节作用，高度乙酰化后则降低其免疫调节作用，即甘薯糖蛋白引入乙酰基和硫酸基团后，其免疫调节活性发生了改变，这些均表明了甘薯糖蛋白的结构与其免疫调节活性有密切的关系。

Histone acetyltransferases and deacetylases function antagonistically to control histone acetylation.

组蛋白的乙酰化在调节染色体结构和功能中起着重要的作用，而这种调节受组蛋白乙酰化酶和去乙酰化酶的共同调节。

Hepatic cirrhosis, virus hepatitis, alcohol, adipositas, diabetes mellitus, non-Alcoholic fatty live, flavacin and other chemcial carcinogens or water and soil factor are the nanocephalous cause of hepatocarcinogenesis which has been generally accepted.

HDAC6作为组蛋白脱乙酰化酶家族一员通过微管去乙酰化和HSP90的去乙酰化调控基因转录，改变细胞的运动能力从而参与肿瘤发生发展和肿瘤的转移以及肿瘤血管的生成。

As a key step of the synthesis, the Friedel-crafts acylation was researched. And the optimal operation variables were determined through orthogonal experiment: when 0.lmol acetanilide, 0.26mol aluminum chloride, 0.12mol propionyl chloride and 200ml carbon disulfide are introduced, and the reaction time is 5 hour, the yield can be up to 57.3%. The solid super acid catalyst was preliminary studied. Four solid super acid catalysts were prepared to take the place of aluminum chloride, and it was indicated that AlCl3 acidic resin can better catalyze the Friedel-Crafts reaction of acetanilide.

对合成路线中的Friedel-Crafts酰基化反应进行了研究，运用正交实验设计确定了最佳工艺条件：当乙酰苯胺用量为0.1mol时，AlCl_3用量为0.26mol、丙酰氯用量为0.12mol、溶剂用量为200ml、反应时间为5h，产率可达到57.3％；对于固体超强酸催化剂进行了初步研究，合成了四种催化剂，其中负载AlCl_3强酸性树脂对于乙酰苯胺的Friedel-Crafts酰基化具有一定的催化活性。

Most of the known acetylated proteins have been identified by radioactive detection or immunedetection, however, both radioactive detection and immunodetection provide evidence for acetylation but do not give information about the number of acetylation sites in a protein.

传统乙酰化蛋白鉴定的方法有放射性检测和免疫亲和检测，但是这些方法都仅能检测到乙酰化蛋白的存在，不能得到具体的乙酰化修饰位点信息。

The optimal derivatization condition is reducting reaction 2.5h at 50℃followed by acetylating 2.5h at 90℃.

总结出了单糖衍生化最佳的反应条件为还原温度50℃、还原时间2.5h；乙酰化温度90℃、乙酰化时间2.5h。

Three methodsconventional direct acylation,acylation by phase transfer catalyst(PTC,and ionexchange-acylation were selected for the purpose of acetylating κ-carrageenan with 30kDa molecular weight.

选择常规直接酰化、相转移催化酰化和离子交换-酰化共3种方法对3万中等分子量的κ-卡拉胶进行了乙酰化反应。

"Acetylating H3K4 and demethylating H3K9 can actiate a gene; deacetylating H3K4 and methylating H3K9 can silence it," Karpen explains."Multiply modified at arious locations, these histones are a major factor in changing the functions of chromatin, independent of DNA sequence."

&H3K4的乙酰化和H3K9的去甲基化使基因活化；而H3K4去乙酰化和H3K9的甲基化则使基因沉默，& Karpen讲解道，&组蛋白的多部位多重调节是改变染色质功能的主要因素，并与DNA的序列无关&

Methods After treated with a specific demethylating agent,Aza and acetylating agent, TSA, the status of 5'CpC island methylation of ING1b gene in HT29 human colon cancer cell line was analyzed using methylation specific polymerase chain reaction,and the level of histone acetylation was analyzed by chromatin immunoprecipitation,and reverse transcription polymerase chain reactionwas used to examine ING1b mRNA expression.

应用特异性DNA甲基转移酶抑制剂5-氮-2'-脱氧胞苷（5-Aza-2'-dc，以下简称Aza）及组蛋白去乙酰化酶抑制剂曲古抑菌素A作用人结肠癌细胞株HT29后，用甲基化特异性PCR检测该ING1b基因核心启动子区域CpG岛甲基化情况，用染色质免疫沉淀检测其乙酰化组蛋白绑定的DNA情况，并用逆转录聚合酶链反应检测ING1bmRNA表达。

The results indicated that the histone deacetylase inhibitors had effects on the morphology of the polytene chromosomes.

2，利用RT-PCR技术，对去乙酰化酶抑制剂处理后的果蝇的热休克基因的表达水平进行检测，结果表明经组蛋白去乙酰化酶抑制剂处理后的果蝇幼虫，其热休克基因的表达高于基础水平，也就是说去乙酰化酶抑制剂诱导了热休克基因的表达。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。