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This implies that the increase of genetranscripts is because of the positive effect of TSA on acetylation in reprogramming.

在aphicicolin单独处理组中基因的表达水平也没有显著升高,提示基因表达量的显著增加是由于TSA诱导了核重编程过程中组蛋白高度乙酰化而引起的。

Based on these data, we proposed a hypothetical model for the involvement of reversible histone acetylation in transcriptional regulation of the p16INK4a gene.

基于这些实验结果,我们推测出可逆的组蛋白乙酰化参与p16INK4a基因的转录调控的模型。

MiR-217 is expressed in human atherosclerotic lesions and is negatively correlated with SirT1 expression and with FoxO1 acetylation status.

在人类动脉粥样硬化斑块中也有miR-217的表达,这一表达也与SirT1的表达以及Fox01的乙酰化状态呈负相关。

After acetylation of cellulose, the allomorph of CTA changed and the crystallinity decreased; however, amorphism is dominant in CDA obtained by hydrolysis from CTA and spinning resulted in the reduction of crystallinity in CDA.

纤维素乙酰化后形成CTA,其晶型发生变化,结晶度降低;而CTA水解后得到的CDA,无定形占明显优势,纺丝过程中的取向又会进一步降低CDA的结晶度。

The Nterminal cyclization of peptides, as one of a variety of modification introduced in sample preparation, has been preliminarily studied in this work.

目前,肽段鉴定时常用的添加残基修饰有甲硫氨酸的氧化和半胱氨酸的氨乙酰化,而对其它修饰研究很少。

On the other hand, we suggest that the STAT3-induced histone deacetylation in the IL-4 promoter may play an initial role in IL-4 suppression.

另一方面,我们认为STAT3诱导的IL-4启动子组蛋白去乙酰化在IL-4基因的抑制中发挥了起始性的作用。

In young human umbilical vein endothelial cells, human aortic endothelial cells, and human coronary artery endothelial cells, miR-217 induces a premature senescence-like phenotype and leads to an impairment in angiogenesis via inhibition of SirT1 and modulation of FoxO1 (forkhead box O1) and endothelial nitric oxide synthase acetylation.

在婴儿脐静脉内皮细胞、人类主动脉内皮细胞以及冠状动脉内皮细胞中,miR-217可以诱导这些细胞出现一种早衰样表型,进而通过抑制SirT1的表达、调控Fox01以及内皮细胞一氧化氮合酶的乙酰化来损伤新生血管的形成。

Increased hepatic acetylation of histone H3 in the IUGR offspring might be caused by decreased HDAC1 expression in nuclear protein. This may contribute to the transcription change of some genes in the hepar.

IUGR大鼠肝细胞核中HDAC1蛋白表达降低,引起组蛋白H3的乙酰化水平增高,染色质的表观遗传学变化可能是肝脏某些基因转录调控变化的分子基础。

Methods:The target compounds were synthesized from acylation of polyethylene glycol to hydroxy group of ursolic acid by polymer polycondensation method.

通过高分子缩合的方法,将酰化的聚乙二醇接枝到熊果酸的羟基上,得到目标产物。

The degradation kinetics, effect of irradiation on the degree of deacetylation of chitosan and the main chain scission mechanism have been studied.

用 γ射线照射壳聚糖使之发生辐射降解,研究了降解反应的动力学、辐射对壳聚糖脱乙酰化度的影响以及大分子链的断链机理。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。