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"We looked at the status of the histones and found surprisingly that thymoquinone increased the acetylation process," Dr.

"我们观察组蛋白的状态并且令人惊讶地发现百里香醌能增强乙酰化的过程" Dr。

This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate invitro.

Elp3对乙酰化的促进作用,和对HDAC6介导体外基质乙酰化的阻碍作用,更进一步的证实了上述观点。

During the two critical periods—gametogenesis and preimplantation development, there are genome-wide epigenetic reprogramming in gametes and embryos, which plays important roles in the erasion or creation of imprinting, gene silencing and tissue-specific gene expression.

其中关键时期是配子形成期和胚胎植入前期,最主要内容是全基因组DNA"CpG岛"甲基化和染色质组蛋白乙酰化的有规律变化,结果是配子遗传印记的消除与重建、植入前胚胎大范围基因的静默和组织特异性基因表达的确定。

Thus a better method of preparing free 2-OH glycoside with less reaction steps was obtained.

对于2,3-二-O-乙酰保护基的糖苷,2-O-去乙酰化的效果更好。

Noma de México and the Instituto Nacional de Cancerolog?a, Mexico, demonstrate, for the first time, that a combination of a DNA methylation and a histone deacetylase inhibitor, can reactivate the expression of more than a thousand genes in primary tumours of breast cancer patients.

在PLoS ONE开始的一期,来自墨西哥国家癌症研究所和国家Aut大学Investi gaciones Biomédicas研究所的Due馻s-Gonzalez博士领导研究组第一次证明DNA甲基化和组蛋白去乙酰化的抑制物联合可以使乳腺癌患者在初期肿瘤时超过一千个基因的表达失活

Noma de México and the Instituto Nacional de Cancerolog?a, Mexico, demonstrate, for the first time, that a combination of a DNA methylation and a histone deacetylase inhibitor, can reactiate the expression of more than a thousand genes in primary tumours of breast cancer patients.

在PLoS ONE开始的一期,来自墨西哥国家癌症研究所和国家Aut大学Inesti gaciones Biomédicas研究所的Due as-Gonzalez博士领导研究组第一次证明DNA甲基化和组蛋白去乙酰化的抑制物联合可以使乳腺癌患者在初期肿瘤时超过一千个基因的表达失活

By treatment with TMSOTf, peracetylated chitobiose,-triose, and -tetraose weretransformed into corresponding oxazolines.

乙酰化的几丁二糖,三糖和四糖在TMSOTf处理下转变成相应的〓唑啉化合物。

Part 2. The peracetylated chito-oligosaccharides were obtained by acetolysis of chitin.

Part 2。通过几丁质的乙酰解得到全乙酰化的几丁寡糖。

Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue.

这一命题中的关键之处在于乙酰化在生物调控中的重要作用。目前蛋白质组学已经发现了上千的被乙酰化的哺乳动物蛋白,中国科学家的这些发现证明了代谢酶。

Then we compared cleavage rate and blastocyst rate among different groups. After that we evaluated the quality of blastocysts by using ICM/TE (Inner cell mass/Trophectoderm cells) ratio via staining with propidium iodide and Hoechest333258, and analyzed the level of genome methylation and histone acetylation by immunofluorescence.

比较各组受精卵的卵裂率和囊胚发育率;并应用碘化丙啶和Hoechest333258对囊胚进行染色,利用ICM/TE值评价各组胚胎体外发育的质量;同时将囊胚进行免疫荧光染色,观察其基因组甲基化和组蛋白乙酰化的水平。

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