乙酰化

The purpose of this current study was to understand the role of acetylation in regulating Hsp90 function.

当前研究的目的是明确乙酰化在调节Hsp90功能中所起的作用。

In the recent decade, more and more attention has been paid to the roles of acetylation in transcription regulation.

尤其是近十多年来，乙酰化在真核生物基因表达调控中的作用日益受到人们的关注。

In eukaryotes, the acetylation of histones was discovered many years ago.

在真核生物中，很早就发现了组蛋白的乙酰化现象。

Backgroud: The acetylation of histones plays very important role in expression of gene.

研究背景：组蛋白乙酰化修饰在基因表达调控中有非常重要的作用和意义。

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression.

赖氨酸乙酰化是可逆的蛋白翻译后修饰，在基因表达调控中起重要作用。

The lower expression of p21WAF1 in gastric cancer is partly due to lower level of histone acetylation.

胃癌组织p21WAF1的表达降低至少部分归因于组蛋白乙酰化水平的低下。

However, relatively lower column utilization limits its application to the complex proteome isolation. In case of binding biotin molecules to a specific kind of functional groups existed in protein structure, and flowing the digested peptides over the affinity column in which avidin has been immobilized, biotinylated peptides can be selectively separated and the complicated system is simplified.

因此根据需要，变换生物素试剂与蛋白质反应的作用位点，就可以选择性地分离出不同的目标肽段，从而大大提高亲和色谱柱的使用效率，降低亲和分离的成本；结合乙酰化同位素标记技术，还可以建立多种针对不同目标肽段的特色定量分析方法，ICAT即是将同位素标记与蛋白质巯基生物素化亲和分离成功结合的一个范例。

Studies on many aspects show that there are four main reasons which cause the epigenetic effects;the methylation of DNA,the acetylation of histones,the change of chromatin structure and the alteration of protein configuration.

多方面的研究表明，导致后生效应的可能原因主要有四个方面：DNA的甲基化、组蛋白的乙酰化、染色质结构背景的改变和蛋白质构型的变化。

The increasing singlets of protons from acetyl group of product were treated as a reporter of the reaction progress. The reaction yields are calculated by the HR/MAS NMR.

利用四个羟基未保护的Nα-Fmoc氨基酸和七种全乙酰化糖为原料，合成了28个糖基化Nα-Fmoc氨基酸，均用高分辨魔角核磁共振技术定量。

It is possile to induce re-expression of a hypermethylated and silenced tumor suppressor gene by intervening in the DNA methylation and in histone deacetylation. It is worthful to deepen the study on the area of"transcriptional path"for prevention and cure of leukemia.

干扰DNA甲基化和组蛋白去乙酰化，以恢复抑癌基因的重新表达是可能的，通过这种&转录途径&防治白血病是值得深入探讨的研究领域。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。