乙酰化

Noma de México and the Instituto Nacional de Cancerolog?a, Mexico, demonstrate, for the first time, that a combination of a DNA methylation and a histone deacetylase inhibitor, can reactiate the expression of more than a thousand genes in primary tumours of breast cancer patients.

在PLoS ONE开始的一期，来自墨西哥国家癌症研究所和国家Aut大学Inesti gaciones Biomédicas研究所的Due as-Gonzalez博士领导研究组第一次证明DNA甲基化和组蛋白去乙酰化的抑制物联合可以使乳腺癌患者在初期肿瘤时超过一千个基因的表达失活

METHODS: Fresh bovine tendo calcaneus collagen was dispersed in 0.5 mol/L acetic acid, co-precipitated with chitosan and lyophilized. Dry membranes were cross-linked in 0.05% glutaraldehyde for 24 hours. In vitro its degrading rate was measured by use of collagenase degrading test. The chitosan-collagen membrane was implanted to subcutaneous dorsal sites of SD rats. After implantation, histocompatibility, vascularity and degradation were observed in vivo.

以酸溶法制备胶原溶液，添加一定比例的脱乙酰化几丁质，冻干成膜，0 。0 5 %戊二醛溶液浸泡交联，行体外酶降解实验，检测其耐受酶降解能力；将制备的几丁质-胶原蛋白膜包埋于 36只 SD大鼠皮下，术后 3、5天，1、2、3、4、6、8和 12周取材，检测其组织相容性、血管化能力及材料在体内降解情况。

The synthesis of nalbuphine hydrochloride from thebaine as starting material was through following processes:oxidation,high-pressure hydrogenation,acetylation,removing methyl of 3-methoxy,hydrolysis,condensation,reduction and finial salification.

以蒂巴因为起始原料，经氧化、高压氢化、乙酰化、氰化、脱3-位甲氧基的甲基、水解、缩合、还原、成盐，合成了盐酸纳布啡，总收率达18。

We expounded the N-alkylation, tricholroacetylation and bromination of pyrrole in chapter two.

第二章，论述了吡咯的N-烷基化、三氯乙酰化及溴代反应。

The demethylation of DNA and acetylation of core histone reconstitute chromosome struction which is beneficial to gene transcription.

DNA去甲基化与组蛋白乙酰化导致染色质构象发生有利于基因转录的变化，基因具有转录活性。

This result provided the reference for adjusting dosage regimen of the drug subjected to the metabolism of demethylation and acetylation for clinic.

可为临床调整经去甲基化、乙酰化代谢药物的用药方案提供参考依据。

We have investigated whether the combination of decitabine and a clinically relevant inhibitor of histone deacetylase activity (belinostat, PXD101) can further increase the re-expression of genes epigenetically silenced by DNA methylation and enhance chemo-sensitisation in vivo at well-tolerated doses.

我们研究了地西他滨联合组蛋白去乙酰化酶抑制剂（belinostat，PXD101）是否可以进一步增加DNA甲基化后生沉默基因的重新表达，在耐受性良好的剂量下增加化疗敏感性。

Methods n-Cetyl-l-thio-β-D-galactoside was synthesized by a series of reaction from galactose and incorporated into Small Unilamellar Vesicles which was prepared by sonication at the ratio for L-α-PC∶Chol∶L-α-PE as 7∶2∶1, with or without 10 mol%Cetyl-gal.

半乳糖经乙酰化、溴化、缩合、亲核取代反应制备半乳糖新糖脂质并与其他脂质制备脂质体，在二氯化锡还原作用下用99mTc标记脂质体，进行动物体内靶肝实验，用γ计数器检测各脏器放射性，计算摄取率。

Such changes in thiols by allyl sulfurs may also account for the observed hyperphosphorylation of specific cell cycle proteins and the histone hyperacetylation that has been correlated with suppressed tumor cell proliferation.

这些烯丙基硫化物引起的硫醇的改变同时也可以使特异性细胞周期蛋白过磷酸化及组蛋白过乙酰化，从而抑制肿瘤细胞增殖。

Results The 5'CpG island methylation in the core promotor of ING1b gene was detected in HT29 human colon cell line, and tunned to demethylation after treatment with Aza and TSA.

结果 HT29人结肠癌细胞株ING1b基因核心启动子区域存在CpG岛半甲基化，且乙酰化水平低，mRNA表达水平低。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。