乙酰化

This study aims at the application of ESI-MS and MALDI-MS in the identification of acetylation of mouse liver.

本论文的研究工作旨在考察两类生物质谱技术ESI-MS和MALDI-MS在乙酰化蛋白质翻译后修饰鉴定中的应用及其应用于小鼠肝乙酰化修饰谱的鉴定研究。

Histone acetylation and deacetylation are the most common forms involved in chromatin modification, which participate in gene transcription regulation.

组蛋白乙酰化和去乙酰化是染色质修饰中最为常见调节方式，参与基因的转录调控。

This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate invitro.

Elp3对乙酰化的促进作用，和对HDAC6介导体外基质乙酰化的阻碍作用，更进一步的证实了上述观点。

OBJECTIVE: To investigate the effects of intrauterine growth retardation caused by malnutrition during pregnancy on the acetylation of histone H3 and expression of histonedeacetylase1(HDAC1) in the hepar of the adult offspring and to explore the relationship between them.

目的：研究孕期营养不良造成的宫内生长受限(intrauterine growth retardation，IUGR)大鼠肝脏中组蛋白H3的乙酰化水平，以及组蛋白去乙酰化酶1 (histonedeacetyl-ases，HDAC1)的表达变化，探讨两者之间的相互联系。

BMI-1(B-cell-specific Moloney murine leukemia virus integration site 1), a Polycomb group repressor, is always present as a PcG complex combined with RING1, HPC2, Mph2, et al. BMI-1 prolongs cells'capacity to proliferate and represses their senescence by repressing the transcription of CDKN2A through acetylhydrolasing or deacetylhydrolasing the Polycomb response elements in chromosome.

BMI-1 (B-cell-specific Moloney murine leukemia virus integration site 1)属于PcG家族，它与该家族其他成员如RING1，HPC2，Mph2等结合形成蛋白复合体，作用于染色质PREs位点，通过对组蛋白进行乙酰化和去乙酰化修饰，从而稳定抑制CDKN2A转录，最终促进细胞的增殖并抑制细胞凋亡。

The patients with rheumatoid arthritis with the slow NAT2 acetylator genotypes have been shown to have more side effects than fast acetylator genotypes when taking SASP.

同时也有研究发现慢型乙酰化表型的风湿性关节炎患者在服用SASP后，与快型乙酰化表型患者相比，副反应发生率明显升高。

In this review, we discussed the consequences of inhibiting histone deacetylases in cycling versus non-cycling cells, in light of the dynamics of histone acetylation patterns with a specific emphasis on heterochromatic regions of the genome.

本综述通过讨论HDACIs对周期和非周期细胞中组蛋白去乙酰化酶的抑制结果，来阐明组蛋白乙酰化模式的动力学特征，特别是对基因组异染色质的作用。

To elucidate the possible mechanism of differentiation and /or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor, the level of acetylated histone H3 was detected by Western blot, p21~ WAF1expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin，TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Westernblot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21WAF1表达量的改变。

To elucidate the possible mechanism of differentiation and/or apoptosis in NB4, K562 cells induced by tributyrin, a histone deacetylase inhibitor , the level of acetylated histone H3 was detected by Western blot, p21(superscript WAF1) expression was detected by semi-quantitative RT-PCR.

为了探讨组蛋白去乙酰化酶抑制剂三丁酸甘油酯(tributyrin， TB)诱导NB4、K562白血病细胞分化和凋亡的作用机制，利用Western blot方法及逆转录聚合酶链反应检测TB作用前后NB4、K562细胞组蛋白H3乙酰化水平以及p21(上标 WAF1)表达量的改变。

Virtually every enzyme in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, the urea cycle, fatty acid metabolism, and glycogen metabolism was found to be acetylated in human liver tissue.

这一命题中的关键之处在于乙酰化在生物调控中的重要作用。目前蛋白质组学已经发现了上千的被乙酰化的哺乳动物蛋白，中国科学家的这些发现证明了代谢酶。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。