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Covalent modification of four isolated alkannin derivatives (alkannin, acetylalkannin,β,β dimethylacrylalkannin and β acetoxyisovalerylalkannin, respectively) on rabbit muscle latate dehydrogenase and yeast Alcohol Dehydrogenase has been studied.

为研究紫草萘醌类化合物的细胞毒性作用机制,从新疆软紫草根中分离出四种紫草萘醌类化合物β,β二甲基丙烯酰阿卡宁(1),乙酰阿卡宁(2 ),β乙酰氧基异戊酰阿卡宁(3)和阿卡宁(4)。

In this paper, Claisen condensation of isochroman ?4?one as starting material with diethyl oxalate is carried out to form β?diketone compound of isochroman ?4?one.

以异色满酮 4为起始原料,经Claisen缩合得其β二酮衍生物,再与水合肼进行Knorr反应环合成 3 乙氧甲酰基和 3 肼甲酰基异色满并吡唑衍生物,通过酰肼与糠醛反应成腙后,分别与巯基乙酸和氯乙酰氯反应合成了标题化合物

Naphthalene acetyl chloride was prepared firstly by the reaction betweenα-naphthylacetic acid and SOCl2 in anhydrous benzene, then reacted with potassium thiocyanate to obtainα-naphthalene acetyl isosulfocyanate, as taking an addition reaction with p-chloro benzoyl hydrazine the novel compound N-naphthalene acetyl-N'-p-chloro benzoylamino thiocarbamide was finally synthesized.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯,然后与硫氰酸钾反应生成α-萘乙酸基异硫氰酸酯,再与对氯苯甲酰肼进行加成反应,生成新型化合物N-萘乙酰基-N'-对氯苯甲酰氨基硫脲。

Treatment of N-p-tolylsulfonylindole 1 with acetyl chloride in dried dichloromethane gave the title compound, N-p-tolylsulfonyl-3-acetyl-indole 2 C17H15NO3S, M(subscript r=313.36 in 89% yield. Single-crystal structure of 2 was determined by X-ray crystallography.2 crystallizes in the triclinic system, space group P-1 with a=10.0264(13), b=12.5913(16), c=14.1621(18)?

N-对-甲苯磺酰-吲哚(1)在二氯甲烷中与乙酰基氯反应得到产率为89%的N-对-甲苯磺酰-3-乙酰基-吲哚(2)(分子式:C17H15NO3S,分子量:313.36),用单晶X-射线衍射方法测定了2的晶体结构并表明:属三斜晶系,空间群为P-1,单胞参数为a=10.0264(13),b=12.5913(16),c=14.1621(18)?

They are, 4 21-amidohydrocortisone Ba1~Ba4, 10 21-amidoprednisolone Bb1~Bb10, 4 21-amidomethylprednisolone Bc1~Bc4, 4 21-amidodexamethasone Bd1~Bd4, 1 21-amidobetamethasone Be1, 1 21-amidoRS Bf1, 1 21-amidocortisone Bg1, 1 21-amidoprednisone Bh1. The amido groups were acetamido, nicotinamido, hemesuccinamido, benzoylamido, methanesufonamido, or arylsufonylamido.

包括:4个21-酰胺基氢化可的松(Ba1~Ba4),10个21-酰胺基氢化泼尼松(Bb1~Bb10),4个21-酰胺基甲泼尼龙(Bc1~Bc4),4个21-酰胺基地塞米松(Bd1~Bd4),1个21-酰胺基倍它美松(Be1),1个21-酰胺基RS(Bf1),1个21-酰胺基可的松(Bg1),1个21-酰胺基强的松(Bh1)。21-酰胺基分别为乙酰胺基、烟酰胺基、单琥珀酰胺基、苯甲酰胺基、甲烷磺酰胺基或取代苯磺酰胺基等。

Objective To determine the contents of residual acetone in acetoacetic ester,the raw material for the synthesis of Edaravone, by gas chromatography.Methods Sample solution was injected on a GDX column (0.18 mm~0.25 mm) with nitrogen as the carrier gas.The residue was calculated by the external standard method.

摘要] 目的:用气相色谱法测定依达拉奉合成起始原料乙酰乙酸乙酯中丙酮的残留量方法:采用固定相二乙烯苯乙基乙烯苯型高分子孔小球(直径为0.18 mm~0.25 mm),氮气为载气,用外标法测定乙酰乙酸乙酯中残留丙酮的含量。

The major contents in this thesis are described as follows:(1) Seven new thiol fluorescence reagents containing 2-phenylbenzoxazole (or 2-phenylbenzothiazole) derivatives or benzanthrone as fluorphore and iodinacetylamine or maleimide as reaction groups have been synthesized.

本论文的研究工作主要分为以下几个方面:(1)以碘乙酰胺或马来酰亚胺为反应基团和以2-芳基苯并噁唑类化合物或苯并蒽酮为荧光团,首次合成了七种新的碘乙酰胺类和马来酰亚胺类巯基荧光试剂。

Our main products category has chloride (pivaloyl chloride, acetyl chloride, Propionyl chloride, methyl acryloyl chloride, butyl chloride, 2 - furyl chloride already chloride, acryloyl chloride, is amyl chloride, etc.) and acids (positive acid, pivalate, propionate, acetic acid, methyl acrylate, 2 - furoic acid, etc.) and so on dozens of products.

我公司主要生产的产品有酰氯类(特戊酰氯、乙酰氯、丙酰氯、甲基丙烯酰氯、正丁酰氯、2-呋喃甲酰氯、己酰氯、丙烯酰氯、正戊酰氯等)和酸类(正丁酸、特戊酸、丙酸、乙酸、甲基丙烯酸、2-呋喃甲酸等)等几十种产品。

The pathway The first committed step in Fatty acid biosynthesis is the carboxylation of acetyl CoA to form malonyl CoA which is catalyzed by the biotin-containing enzyme acetyl CoA carboxylase.

途 径 脂肪酸合成的第一个关键步骤是乙酰-COA 羧基化形成丙二酰单酰 COA ,这一步是在含生物素的酶乙酰-COA 羧化酶的催化下进行的。

Harms: Versus placebo: The review found that polyuria and paraesthesia were significantly more common with acetazolamide than with placebo AR for polyuria: 33% with acetazolamide v 6% with placebo; RR 4.24, 95% CI 1.92 to 9.37; AR for paraesthesia:43% with acetazolamide v 10% with placebo; RR 4.02, 95

害处:与安慰剂相比:该综述发现,与安慰剂相比,乙酰唑胺更常发生多尿及感觉异常,多尿的事件发生率:乙酰唑胺组为33%,安慰剂组为6%,RR为4.02,95%CI为1.92~9.37;感觉异常的事件发生率:乙酰唑胺组为43%,安慰剂组为10%,RR为4.02,95%CI为1.17~9.93[4]。

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