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School "of acetaminophen refined the process of acylation of the multimedia simulation design" system.

学院《对乙酰氨基酚的酰化精制过程的多媒体仿真设计》系统开发。

The paper proposed a possible binding mode of MS-275, a benzamide histone deacetylase inhibitor, to HDAC by intensive docking study.

通过计算机模拟的对接过程研究,发现了MS-275--一种苯甲酰胺类的组蛋白去乙酰酶抑制剂与酶的可能的全新结合方式。

A series of 2-acetylformanilides were prepared,followed by thiolation with Lowesson reagent to afford 2-acetylthioformanilides,which further reacted with Mn3·2H2O in glacial acetic acid under microwave irradiation to afford 2-acetyl benzothiazole s.

合成了一系列的硫代酰胺,研究了它们在微波辐射醋酸锰作用下发生氧化自由基环化反应,成功地合成了一系列2-乙酰基苯并噻唑衍生物,其结构经红外光谱、核磁共振谱和质谱得到了证实

In the fifth chapter, a series of betulin derivatives including 28-acetoxybetulin, 28-tritylbetulin, 28-benzoylbetulin, 3-0-P-D-glucopyranoside of betulin and some betulinic acid conjugate containing amino acid were synthesized and confirmed by MS and NMR.

第五章分别合成得到了乙酰化白桦酯醇、28-苯甲酰化白桦酯醇、28-三苯甲基化白桦酯醇、3-O-β-D-glucopyranoside of betulin和一系列的白桦酯酸苷氨酸的衍生物,并分别对其进行了结构鉴定。

In the fifth chapter, a series of betulin derivatives including 28-acetoxybetulin, 28-tritylbetulin, 28-benzoylbetulin, 3-O-β-D-glucopyranoside of betulin and some betulinic acid conjugate containing amino acid were synthesized and confirmed by MS and NMR.

第五章分别合成得到了乙酰化白桦酯醇、28-苯甲酰化白桦酯醇、28-三苯甲基化白桦酯醇、3-O-β-D-glucopyranoside of betulin和一系列的白桦酯酸苷氨酸的衍生物,并分别对其进行了结构鉴定。

The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法以克拉霉素为起始原料,经水解、乙酰化、环碳酸酯化、氧化、脱碳酸酯化、酰化、环氨基甲酸酯化和环合等反应合成目标化合物。

The main products are: phosphorous acid, acetyl chloride, cyclohexyl chloride.

主要产品有:亚磷酸、乙酰氯、环已甲酰氯。

Methods: Uses carbon tetrachloride (CC14) 2ml/kg, thioacetamide 200mg/kg, the abdominal cavity to inject separately, Establish model which the rat acute liver damages; Guarantees the liver profit stomach mixture, the polyene phosphatide acid radical choline capsule, the glycyrrhizic acid diamidogen capsule fills the stomach.

分别用四氯化碳(CC14)2mL/kg,硫代乙酰胺200mg/kg,腹腔注射,建立大鼠急性肝损伤的模型;保肝益胃合剂,多烯磷脂酰胆碱胶囊,甘草酸二胺胶囊灌胃治疗。

With benzoic acid, terephthalic acid, 2. 6naphthalene dicarboxylic acid, dimethyl-2, 6-naphthalene dicarboxylate as solutes, water, acetic acid, N, N-dimethylformamide, N, N-dimethylacemide, dimethyl sulphoxide, N-methl2-ketopyrolidine, and the mixture of water and acetic acid as solvents respectively, the solubilities of 15 binary systems and 4 ternary systems were determined.

实验以苯甲酸、对苯二甲酸、2,6-NDCA、2,6-萘二甲酸二甲酯为溶质,以水、醋酸、N,N-二甲基甲酰胺、N,N-二甲基乙酰胺、二甲基亚砜、N-甲基-2-吡咯烷酮以及水和醋酸的混合溶液为溶剂,测定了十五个二元物系和四个三元物系的溶解度数据。

The diluent contain magnesium chloride, potassium citrate, sodium glutamate, dipotassium hydrogen phosphate, monopotassium phosphate and fructose, semen vitality is hightest after frozen.The average value is 0.52,highter than other 5 diluent significantly (P﹤0.01).So chose this diluent as semen cryopreservation diluent on chicken. Definite cryoprotectant, equilibrium time and thaw temperature:On the base of test one,research freeze sheltering effect about glycerin, DMSO ,DMA and DMF, each with 4 consistency.The result showed that 10%DMSO sheltering effect is the best, the next is 4%DMA,semen vitality are 0.58 and 0.55 after frozen.

冷冻保护剂、平衡时间和解冻温度的确定在试验一的基础上,研究甘油、二甲基亚砜、二甲基乙酰胺、二甲基甲酰胺4种冷冻保护剂在4种浓度下对鸡精子的冷冻保护作用,结果表明,10%DMSO保护效果最好,其次为4%浓度的DMA,精液冻后活力分别为0.58和0.55,两者之间差异不显著(P﹥0.05)。

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