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Cytotoxic effect was demonstrated with nitrogen mustard, nitromin, sarcolysin, thio-TEPA and myleran at concentrations of 7, 10, 25, 35, 100, and 100μg/ml respectively.

氮芥及氧化氮芥在7—10微克/毫升,溶肉瘤素和新恩必恨于25—35微克/毫升,三乙酰硫代磷酰胺和丁二醇二甲磺酸酯在100微克/毫升,都出現了显著的細胞毒作用,使細胞很快死亡溶解;但6-巯基嘌吟和氨基喋吟未表現作用。

Molecularly imprinted polymers of sulfamethazine(SM 2 ) were prepared with silica gel as a sacrificial material, methacrylic acid and 4 vinylpyridine(4 Vp) as functional monomers, glycol dimethacrylate as crosslinker. The polymer properties were investigated by static adsorption experiments. Scatchard analysis shows that the adsorption ability of MAA MIP is superior to that of 4 Vp MIP. The dissociation constant of MAA MIP is 9 59×10 -4 mol/L. The value of apparent binding a...

以磺胺二甲嘧啶为模板分子,分别用甲基丙烯酸和4乙烯基吡啶为功能单体,二甲基丙烯酸乙二醇酯为交联剂,采用牺牲硅胶法合成了磺胺分子印迹聚合物,通过静态吸附实验,系统研究了不同单体对聚合物识别性能的影响;Scatchard分析表明,以甲基丙烯酸为单体的聚合物具有较高的吸附能力,其离解常数Kd为959×10-4mol/L,最大表观结合位点数Qmax为3070μmol/g。

Three methods are used to prepare molecular imprinted polymers,which include conventional bulk technique or polymerization with ultraviolet initiated in low temperature and polymerization with silica-gel as sacrificial materials. In the polymerization procedure , Sulfamethazine(SM2)and Sulfisoxazole were used as target template molecules, methacrylic acid and 4-vinylpyridine(4-VP) and acrylamide were selected as functional monomers, ethylene glycol dimethacrylate as crosslinker, azobisisobutyronitrile was used as initator.

主要工作如下:首先,以磺胺异噁唑和磺胺二甲嘧啶为模板,分别以4-乙烯基吡啶,甲基丙烯酸,丙烯酰胺为功能单体,以二甲基丙烯酸乙二醇酯为交联剂,偶氮二异丁腈为引发剂,采用了传统方法(60℃恒温水浴)、牺牲硅胶法及低温紫外光聚合法等三种方法合成了一系列的磺胺类药物印迹聚合物。

Aqua, Sorbitol, PPG-1 PEG-9 Lauryl glycol ether, Hydrolyzed elastin, Hydrolyzed wheat gluten, Hydrolyzed collagen, Hydrolyzed glycosamino-glycans, Humulus lupulus, Propylene glycol, Triethanolamine, Sodium hydroxide, Carbomer, Maris limus extract, Ostrea extract, Imidazolidinyl urea, Parfum, Benzyl salicylate, Coumarin, Alpha isomethyl ionone, Hexyl cinnamal, Buthylphenylmethylpropionate, Linalol, Methylisothiazolinone, Methylchloroisothiazolinone.

水,山梨醇, PPG 公司- 1聚乙二醇- 9十二烷基醇醚,水解弹性蛋白,水解小麦面筋蛋白,水解胶原蛋白水解粘多糖,多聚糖,啤酒花提取物花,丙二醇,三乙醇胺,氢氧化钠,卡波姆,马里斯提取物,牡蛎提取物,咪唑烷基脲,香水,水杨酸苄酯,香豆素,阿尔法 l 紫罗兰酮,己基肉桂醛,丁苯基甲基丙醛,芳樟醇,甲基异噻唑啉酮,甲基氯异塞唑晽酮。

A small molecule core (TMP-SK3)with three terminal carboxyl groups was synthesized successfully by the reaction of 1,1,1-trihydroxymethylpropane with the excessive sebacic acid diacetic anhydride.

以1,1,1-三羟甲基丙烷与过量癸二酸二乙酸酐反应,制得了端羧基的三官能度小分子核三癸二酸三羟甲基丙烷酯(TMP-SK3)。

Dibenzyl oxalate was synthesized from oxalic acid, potassium hydroxide and benzyl bromide under microwave irradiation using tetrabutylammonium bromide as phase-transfer catalyst and polyethylene glycol-200 as solvent.

在微波辐射条件下,以草酸、氢氧化钾和溴化苄为原料,四丁基溴化铵为相转移催化剂,聚乙二醇200为溶剂合成了草酸二苄酯,并通过熔点和红外光谱对产物的结构进行了表征。

AIM: To investigate the effect of PD98059, a specific repressor of extracellular signal regulated kinase1/2 (ERK1/2), on the proliferation of the murine lymphocytes. METHODS: Lymphocytes were isolated from lymphoid nodes of BALB/c mouse. After stained with carboxy fluorescein diacetate, succinimidyl ester, the cells were stimulated with polyclonal activators, concanavalin and phorbol 12,13 dibutyrate plus ionomycin.

分离小鼠淋巴结细胞,藉羧基荧光素乙酰乙酸染色,用多克隆刺激剂刀豆A蛋白或者佛波醇酯加离子霉素刺激,以流式细胞术分析PD98059对淋巴细胞增殖的影响;利用碘化丙锭染色分析PD98059对细胞周期的影响。

In this thesis, themethod of moments was used in modeling the graft polymerization of vinyl acetatefrom polyethylene glycol and the vinyl/divinyl atom transfer radical copolymerizationwith cross-linking.

本文运用矩方法分别对聚乙二醇接枝醋酸乙烯酯聚合体系和双烯/单烯的原子转移自由基交联聚合体系进行了深入的建模研究。

Results showed that the monomer conversion increased slightly in the presence of the crosslinking agents The size of particles decreased slowh as the amount of cmsslinking agent increased.and the size distribution of the particles broadened at a higher amount of cmsslinking agent Divinyl benzene was more effective than ethyl glycol dimethyl methacrylate to make polymer crosslinked.During alkali treatment process,void latex particles can be obtained when no DVB or less than 0.5 wt% of EGDMA was used,while muhihollow structure was generated when DVB or more than 1.0 wt% of EGDMA was introduced.The volume expansion of the particles decreased with increasing the amount of emsslinkirlg agents.

结果表明,体系中加入交联剂后,单体转化率都有不同程度的提高;随交联剂用量的增加,乳胶粒粒径略有减小,交联剂用量较高时,乳胶粒粒径分布加宽;二乙烯基苯的交联效率稍高于双甲基丙烯酸乙二醇酯;不加入交联剂及EGDMA用量低于0.5%时,处理后乳胶粒呈空腔结构,加入DVB及EGDMA用量高于1.0%时,处理后乳胶粒呈多孔结构,并且乳胶粒体积增量随交联剂用量的增加而减小。

Methods: The model of evaluating T cell proliferation stimulated with polyclonal activators, ConA was established by vital dye carboxyl fluorescin diacetate succinmidyl ester labeling technique. The effect of a specific inhibitor for p38 MAPK, SB253580, on T cell proliferation on different doses and in different time was estimated by flow cytometry. At the same time, the percentage of proliferating T cells and proliferation index were measured by CellQuest and SPSS10.0 for Windows softwares.

以活体染料羧基荧光素乙酰乙酸琥珀酰亚胺酯染色,建立了在多克隆刺激剂刀豆蛋白A刺激下评价小鼠T细胞增殖的模型,通过流式细胞术分析p38丝裂原活化蛋白激酶的特异性抑制剂SB203580在不同剂量、不同时间对T细胞增殖的作用,并应用CellQuest和SPSS10.0 for Windows软件分析增殖细胞各代所占比例和增殖指数。

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