乙酯基

Methods 4-Hydroxybenzonitrile (2) as the starting material was transformed to 4-hydroxy-thiobenzamide (3) via thioformylation. And ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (4), which was synthesized via cyclization from 3, was treated with hexamethylenetetramine to generate the intermediate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (5). The target compound febuxostat (1) was obtained from 5 by etherification, cyanidation, hydrolysis.

以羟基苯腈为原料，经硫代甲酰化得到对羟基硫代苯甲酰胺(3)，3经环合得到2-（4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(4)，4与乌洛托品反应，得到中间体2-（3-甲酰基－4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(5)，之后再经醚化、氰化、水解得到目标产物(1)。

The constituents were extracted by some solvents. 18 constituents were isolated from Chloroform fraction by different chromatography. 15 constituents were identified by IR ,MS and NMR as follows: 3-sitosterol, P-sitosterylpalm itate,succinate acids, 1, 4-benzenediol, 1, 2-benzenediol, p-hydroxybenzaldehyde, syringaresinol, oleanolic acid, usolic acid, ethyl caffeate , Rosmarinic acid ethylster and etc. In such constituents ,nine compounds were isolated for first time from Origanum vulgare L..

牛至药材经水煮醇沉法所得浸膏，利用溶剂法和色谱法从中分离得到18个单体成分，通过IR、MS、NMR等波谱技术鉴定了其中的15个化合物，分别为β-谷甾醇(1)、β-胡萝卜苷(2)、琥珀酸(3)、对-二苯酚(4)、邻-二苯酚(5)、对羟基苯甲醛(6)、1.2-二羟基-4-异丙基-5-甲基苯(7)、新木脂素(8)、丁香脂素(9)、齐墩果酸(10)、乌苏酸(11)、4-二十六烯(12)、正二十六醇(13)、咖啡酸乙酯(14)、迷迭香酸乙酯(15)等，其中化合物3、4、5、6、7、8、9、14、15等9种化合物均为首次从该属植物中分离得到。

The main contribution of this paper is summarized as follow:1 Copolymer acrylate resin including hydroxyl, carboxylic and amina(-NH_2) is a new type of antifogging system and ahydrophi- lic antifogging constituents which is not found before.2 Water-soluble acrylate resin hydrophilic antifogging coating material is a new-type environmental protection material which takes ethanol as solvent and whose pastiness is adjusted by deionized water.3 The quality rate of accessory soft monomer ethyl acrylate and accessory hard monomer butyl methacrylate is 6 to 4, the quality rate of functional monomers in all monomers is 20 percent, the quality rate of MAA in the functional monomers is 22 percent, the quality rate of β-hydroxyl ethyl acrylate in the functional monomers is 8 to 10 percent and the remainder of functional monomer is acrylic acid.4 Cross-linking agent methylol acrylamide belongs to self-cross-linking system.

本文的主要贡献概述如下： 1 含有亲水羧基、羟基和氨基(-NH_2)丙烯酸共聚树脂是一种新型高效的防雾体系，用的亲水防雾组分是前所未有的。 2 以乙醇为溶剂制得水溶性丙烯酸树脂具有很好的水溶性能和防雾性能，只需加入去离子水就可以调节它的粘度，是一种新型的环保型防雾材料。 3 辅助软单体丙烯酸乙酯和辅助硬单体甲基丙烯酸甲酯最佳配比为质量比6∶4；官能单体占单体总量的20%，甲基丙烯酸占官能单体总量10～15%，甲基丙烯酸β-羟乙酯占官能单体总量的8～10%，剩下的为丙烯酸。

Ethyl dicyanopropionate was synthesized by one-step reaction with sodium cyanide, paraformaldehyde and ethyl cyanoacetate in solvent.

由氰化钠、多聚甲醛和氰乙酸乙酯在溶剂中反应，一步合成二氰基丙酸乙酯，收率达80.2%，含量90.8

Carene, ethyl p?methoxycinnamate and ethyl cinnamate.

3？蒈烯、肉桂酸乙酯和对甲氧基肉桂酸乙酯等。

The active compound Celangulin-V, which is the main active compound against insect pest from Celastrus angulatus Max, was modified at its 6-OH and the core structure β-dihydroagarofuran polyol of Celangulins from the basic hydrolysis of the extract of the root bark of Celastrus angulatus Max was modified by combinatorial chemical method.

主要结果如下： 1、合成了苦皮藤素V6-乙酯、6-烯丙基醚和6-酮等衍生物，通过NMR方法鉴定了化合物的结构，经文献检索均为新化合物，生测结果表明酮衍生物丧失了杀虫活性，乙酯衍生物与苦皮藤素V活性相当，醚衍生物较苦皮藤素V活性提高11倍。

Ethyl phenoxyacetate has been synthesised by the reaction of phenol with ethyl chloroacetate under the condition of solid-liquid phase transfer catalysis using PEG-400 as the catalyst.

于固一液相转移催化条件下，以PEG-400为催化剂，通过苯酚与氯乙酸乙酯反应合成了苯氧基乙酸乙酯。与85％的水合肼作用得到相应的酰肼。

ConclusionThe main components of essential oils are 2,4-bis(1,1-dimethylethyl) phenol (4.4%), tetradecanoic acid (6.96%), n-hexadecanoic acid (7.69%), 9,12-cctadecadienoic acid (6.37%), hexadecanoic acid-2-hydroxy-1- ethyl ester (4.79%) and octadecanoic acid-2-hydroxy-1- ethyl ester (4.77%), respectively.

结论阿给炭挥发油的主要成分为2，4-二树丁基苯酚（4.4％）、十四酸（6.96％）、n-十六酸（7.69％）、-9，12-十八碳二烯酸（6.37％）、软脂酸-2-羟基-1-羟甲基乙酯（4.79％）、硬脂酸-2-羟基-1-羟甲基乙酯（4.77％）。

These salts can beprepared on treatment of phosphinimines with trifluoroaceticanhydride. After addition-elimination, triflromethylated β-enaminoesters and β-iminoesters were synthesized by thereaction of the above salts with organozinc reagents.

通过膦亚胺和三氟乙酸酐反应制备了N-三氟乙酰基氨基膦盐，该膦盐和锌试剂发生加成-消除反应后，合成了含有三氟甲基的β-烯胺酯和β-亚胺酯。

The main compounds of essential oils were Pentadecane（20.88%,46.56%）,Ethyl-cinnamate(25.60%,10.94%), Ethyl-p-methoxycinnamate(28.69%,2.41%),3-Carene(3.31%,11.36%).

主要成分均为十五烷（20.88%，46.56%），桂皮酸乙酯(25.60%，10.94%)，对甲氧基桂皮酸乙酯(28.69%，2.41%)，3-蒈烯(3.31%，11.36%)。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。