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乙酯

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The basic functionalized ionic liquid, 1 -butyl-3-methylimidazolium hydroxide OH, was prepared and used to catalyze the Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate.

合成了碱性功能化离子液体氢氧化1-丁基-3-甲基咪唑,研究了将其作为催化剂催化芳香醛和丙二氰、氰基乙酸乙酯的Knoevenagel缩合反应。

The basic functionalized ionic liquid, 1-butyl-3-methylimidazolium hydroxide, was prepared and used to catalyze the Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate.

合成了碱性功能化离子液体氢氧化1-丁基-3-甲基咪唑,研究了将其作为催化剂催化芳香醛和丙二氰、氰基乙酸乙酯的Knoevenagel缩合反应。

As to the catalytic coupling of aryl bromides, when triphenylphosphine as ligand and malononitrile as subtracts, their isolated yields were generally in 72-88%; While using cyanoacetate instead of malononitrile, the yields were in 67-84%.

当采用常见的三苯基膦为配体、对取代溴苯而言,以丙二腈为底物时,偶联产物的分离产率一般都在72-88%之间;以腈基乙酸乙酯为底物时,分离产率在67-84%之间。

Knoevenagel condensation reaction between aromatic aldehyde, malononitrile or ethyl cyanoacetate is promoted by organocatalyst N-methylimidazole.

以1-甲基咪唑为有机小分子催化剂催化芳香醛与丙二腈或氰乙酸乙酯的Knoevenagel缩合反应,反应速度快,操作方便,产率高,后处理简单。

Based on the problem of various types of catalyst and according to the features of carbonylation catalysts reactions, our team has been designed a series of new metal complexes of benimidazoles, which can be used for carbonylation catalyst of industry. Seven new benzimidazole derivatives were prepared by the o-phenylenediamine、oxalic acid、glycolic acid、monomethyl monopotassium malonate、ethyl cyanoacetate、succinic anhydride. The structures of them were confirmed by IR、Elemental analsis. The crystal structures of d and e were determined by X-ray single crystal diffraction of Germanic Bruker Smart APEX II CCD. The catalysis of them was tested by carbonylation reactions.

本文设计以邻苯二胺和草酸、羟基乙酸、丙二酸单甲酯、氰基乙酸乙酯、丁二酸单甲酯为原料采用PPA催化和无机酸催化法,合成了4种苯并咪唑-2-羧酸衍生物并进行了表征;培养了2个化合物d、e的晶体并测定和讨论了晶体结构;制备了3种未见报道的苯并咪唑金属配合物,对配合物在羰基化法制醋酐-醋酸反应的催化作用进行了初步试验。

Our main products include 5-Methyl-2-pyrazinecarboxylic acid series, Guanine series, Folic acid series, Methyl Cyanoacetate and Ethyl cyanoacetate series, we also have made great contribution in the development of cardiovascular drug, stomach drug, anti-inflammatory drug and antidepressants, such as Nizatidine, Acipimox, Glipizide, Zaltoprofen and Pregabalin, which have been put into production on large scare.

公司主要产品有5-甲基吡嗪-2-羧酸系列,鸟嘌呤系列,叶酸,氰乙酸甲酯,氰乙酸乙酯系列,在心血管药、胃药、消炎药、抗抑郁药等新品开发上有重大建树,先后研制成功,形成批量生产,如尼扎替丁、阿西莫斯、格列吡嗪、扎托洛芬、普瑞巴林,同时具备为客户定制化学品的能力。

However, the molecular mechanisms underlying premature aging up 8-MOP/UVA are as yet unknown. In our studies, dermis of the non-lesion back skin of vulgar psoriatic patients who had been treated by PUVA and the cultured foetus dermic fibroblasts were selected to be observed.

本课题以PUVA治疗寻常型银屑病患者背部非皮损区真皮及培养的胎儿真皮成纤维细胞为对象,采用HE染色、Verhoeff染色、电镜、酶组织化学、免疫组织化学、原位杂交、流式细胞计数仪、三引物PCR、PCR-SSCP技术及PCR产物直接测序等技术和方法,研究了8-MOP/UVA对皮肤光老化形成的影响及芳维A酸乙酯的拮抗作用。

The cracking reaction of Ethylidene diacetate is the key step to manufacture vinyl acetate from C1 compound. The technological development is based on the study of the reaction property and the reactor, and is guided by the process simulation results.

二醋酸亚乙酯裂解反应是C1路线制醋酸乙烯的关键步骤,其工艺的开发离不开反应过程的研究和反应器的确定,而过程数学模拟可以指导过程开发。

In four flavor models, isoamyl alcohol model and ethyl acetate model have good capacity for simulation and prediction, whereas acetaldehyde model and diacetyl model do not.

在建立的4个风味物质模型中,异戊醇和乙酸乙酯模型的仿真能力和预测能力都比较强,双乙酰和乙醛模型的仿真能力和预测能力都比较差,需要进一步研究。

Biological activity of the compounds were studied and the result indicated that the compound 1,1'-ethyl dicarboxylate gem-dimethyl-cyclopropanediacylhydrazine has good activity against bean aphidsin at 250mg/L.

生物活性测定结果表明,在250mg/L的浓度下,化合物1,1'-二羧酸乙酯偕二甲基环丙烷双酰肼对蚕豆蚜虫有较好杀虫活性。

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