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乙胺

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EMB-resistance in 18 isolates was caused by the mutation at coden 306 in embB gene with positive rate of 62.1%. The PCR result was negative in 20 specimen from pulmonary diseases without active TB and 5 negative control strains of no MTB. The data in this study showed high specificity of 100%. Only one specimen in 7 specimen with negative result in acid-fast stain and cultivation was shown alteration in coden 306 in embB gene.

结果:130例活动性肺结核患者痰标本抗酸染色阳性38例,阳性率为29.2%(38/130);罗氏培养阳性为79例,阳性率为60.8%(79/130)。79例培养阳性痰标本中耐乙胺丁醇29例,其中有18例在embB基因met306ATG突变,基因突变率为62.1%。20例非结核肺部疾病患者痰标本和5株非结核分枝杆菌菌株经套式PCR扩增全部为阴性,特异性为100%。7例涂阴培阴PCR扩增阳性的序列中有1例在embB基因306位密码了发生突变。

Methods The internal standard was diazepam, the samples were extracted by ethyl acetate after basified the plasma., the column was Hypersil C18, and the mobile phase mixed of methanol: water(75:25) containing 0.03%-triethylamine.

色谱柱为Hypersil ODS C18 4.0mm×250mm,流动相为含0.03%三乙胺的甲醇:水(75:25),流速1.0ml/min,紫外276nm波长检测。

In the orthogonal designable experiment ,the analysis results of zirconium source, precipitation , the sulfating agent is 1.54%, 2.27%, 5.11%,respectively. This result show that the influence of sulfating agent to the catalytic activity is the biggest. Under the same density of the sulfuric acid soaks, the effect of sulfuric acid is well compared to ammonium sulfate .The second is the precipitation, but the influence of the zirconia source is the smallest.

正交设计实验中锆源、沉淀剂、硫酸化试剂的极差分析结果分别为1.54%,2.27%,5.11%,此结果说明硫酸化试剂对催化剂的影响最大,其次是沉淀剂,锆源的影响最小,同时表明以Zr(NO3)4·5H2O为锆源、乙胺为沉淀剂、硫酸为硫酸化试剂是催化剂的最佳制备方案。

The optimal conditions determineded by experiments were as follow: chloracetic acid : sodium carbonate : isopropyl xanthate : ethylamine=l : 0.58 : 1 : 1.05, water usage is 30 ml/O.lmol chloracetic acid, esterification temperature was 80癈, esterification time was 2h, ammonolysis temperature was 70 C, ammonolysis time was Ih.

实验得出最佳工艺条件为:一氯乙酸:碳酸钠:异丙基黄药:乙胺=1:0.58:1:1.05,水用量为30 ml/0.1mol一氯乙酸,酯化温度80℃,酯化时间2小时,氨解温度70℃,氨解时间1小时。

With 4 Xiu Shuang phenol - A and solid smooth air is raw material, dissolve it in 1 in, 2- 2 chlorine ethane solvents, slow drop adds 3 Yi Ans to carry out solution get together , with 3 Xiu benzene phenol does end dose, thick product sinks by industrial alcohol Xi after, take out to strain , wash is dry , grind white powder form flame retardant assemble carbon sour ester product.

以四溴双酚-A、固体光气为原料,将之溶解在1,2-二氯乙烷溶剂中,缓慢滴加三乙胺进行溶液聚合,以三溴苯酚做封端剂,粗产品经工业酒精沉析后,抽滤,洗涤,干燥,研磨得白色粉末状阻燃聚碳酸酯产品。

Study on the synthetic technology of Ethambutol,Ⅱ.

乙胺丁醇的合成工艺研究;Ⅱ。

Seven patients had recurrence of TB – three in the moxifloxacin group at 11, 16, and 27 months after completing treatment, and four in the ethambutol group at 6, 7, 22, and 32 months.

Conde博士及其同事在文中提到,7例病人出现复发,其中莫西沙星组3例,分别在完整治疗疗程后第11、16和27个月复发;乙胺丁醇组4例,分别在6、7、22和32个月复发。

Only one event, a grade 3 cutaneous reaction, was deemed to be related to the study drug – and that was to ethambutol, not moxifloxacin.

其中只出现一次3级皮肤反应,被认为与本研究中的药物有关,并且发生于乙胺丁醇组而非莫西沙星组。

Compared with control patients who received ethambutol, more patients who received moxifloxacin were culture negative after just 1 week of treatment.

与使用乙胺丁醇的对照组病人相比,在使用莫西沙星后仅一周,很多病人的结核杆菌培养已呈阴性。

In this section, the research and production status of Ethambutol and its key intermediates have been described roundly, the disadvantages and practicability of the synthetic routes for Ethambutol synthesis had also been analyzed and compared in detail.

报告对乙胺丁醇及其关键中间体2-氨基丁醇的国内外的生产及研究状况做了比较全面地总结,并且详细地分析、比较了各条合成路线的优劣及其实用性。

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