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乙氯醛

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Four new salicylaldehyde derivatives with a glucose or mannose moiety were synthesized with 2-tert-butylphenol or 4-tert-butylphenol as the starting material, followed by the formylation, chloromethylation, nucleophilic substitution reaction with the desired carbohydrate. The salicylaldehyde derivatives condensed with ethylenediamine to give the Schiff bases, which coordinated with Mn to afford four novel sugar-based Salen Mn complexes.

首先,分别以2-叔丁基苯酚和4-叔丁基苯酚为起始原料,经过甲酰化反应、氯甲基化反应、和糖类衍生物的亲核取代反应制得了四种新型并入葡萄糖基或甘露糖基的水杨醛衍生物,将它们与乙二胺缩合生成希夫碱配体,得到的配体与过渡金属Mn~(3+)配位制备出四种新型含糖基的Salen Mn配合物。

Thirty-one new chiral phosphorus compounds have been synthesized starting from D-camphor,-alpha-phenylethylamine,-Betti base,-1-(4-nitrophenyl)-2-amino- propane-1,3-diol, L-amino acids (such as serine, phenylalanine, proline etc.) and their application as organocatalysts in asymmetric trimethylsilylcyanation of aldehydes and asymmetric borane reduction of prochiral ketones and ketimines were investigated.

该项目从D-樟脑、-alpha-苯乙胺、-Betti碱、-氯酶胺、L-氨基酸(如丝氨酸、苯丙氨酸、脯氨酸等)出发合成了31个新的手性磷化合物,研究了它们作为有机催化剂在醛的不对称硅氰化反应、潜手性酮的不对称硼烷还原反应以及亚胺的不对称硼烷还原反应中的催化效果。

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