乙氧基

A better understanding of the role of PPAR in insulin action system will be critical in developing more efficacious and safe agent s that act on PPAR and benefit patients with type 2 diabetes. The main content is followed: Synthesis and analysis of 1,3-dicarbonyl compounds. Make use of easily available cheap reagent such as 2-naphthol, 6-hydroxyquinoline, 1,2-dibromoethane, 4- hydroxybenzaldehyde, dimethyl malonate, 2-{4- [(2-napthoxy)ethoxyl] benzyl} malonates and 2-{4 [(1,2,3,4-tetrahydro-6 -quinolinoxy)ethoxyl] benzyl } malonates were synthesized through 6-8 steps in virtue of Williamson, Knoevenagel reaction, Pd/C catalyzed hydrogenation with mild conditions and high yield. The total yield of 40-50%.

本论文的主要内容和研究结果如下： 1，3-二羰基类化合物的合成及分析，采用2-萘酚、6-羟基喹啉、1 ，2二溴乙烷、对羟基苯甲醛、丙二酸二甲酯等常见易得试剂，利用Williamson反应、Knoevenagel反应、钯碳加氢等条件温和且收率高的方法，分别合成了2-{4- [(2-萘氧)乙氧基]苄基}丙二酸衍生物和2-{4 [(1，2，3，4-四氢-6-喹啉氧基)乙氧基]苄基}丙二酸衍生物两个系列8个化合物，经6-8步反应，总收率为40-50%，具有一定绿色化学特性。

The UV-Visible absorption spectra and the fluorescence emission spectra of sixteen tetra-substituted metallo-phthalocyanine complexes {R4PcM, where R=2-［4-(2-sulfonic ethyl)piperazin-1-］ ethoxyl, 2-(piperidin-1-yl)ethoxyl; substitution position at α-position and β-position of phthalocyanine ring; M=Zn, Ni, Coand Cu} were measured.

报道了16种含哌嗪或含哌啶四取代酞菁金属配合物{R4PcM， R=2-［4-(2-磺基乙基)哌嗪-1-基］乙氧基、 2-(哌啶-1-基)乙氧基；取代位置分别在α位和β位； M=Zn， Ni， Co， Cu}的UV-Vis吸收光谱和荧光发射光谱的测定，探讨了中心金属离子、取代基种类及其取代位置、溶剂等因素对酞菁金属配合物UV-Vis吸收光谱和荧光发射光谱性质的影响。

Nine new compounds were characterized, and they were: opuntioside Ⅰ(11), 4-ethoxyl-6-hydroxymethyl-α-pyrone (14),--ester (22), 1-butoxyl--malate (24), ethyl α-L-rhamnopyranoside (26), opuntioside Ⅱ(34), kaempferol 7-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranoside (46), methyl α-D-glucopyranoside-6-(methyl 4-malate)-ester (47), and opuntioside Ⅲ(48). Opuntioside Ⅰ,Ⅱ,Ⅲ and 4-ethoxyl-6-hydroxymethyl-α-pyrone belong to the skelecton of α-pyrone.

新化合物分别是：仙人掌苷Ⅰ（11），4-乙氧基-6-羟甲基-α-吡喃酮（14），琥珀酸乙酯--酯（22），L--苹果酸-1-丁酯（24），乙基α-L-吡喃鼠李糖苷（26），仙人掌苷Ⅱ（34），山奈酚7-O-β-D-吡喃葡萄糖基（1→4）-β-D-吡喃葡萄糖苷（46），α-D-吡喃葡萄糖甲苷-6-（苹果酸-4-甲酯）-酯（47），仙人掌苷Ⅲ（48），其中仙人掌苷Ⅰ、Ⅱ、Ⅲ及4-乙氧基-6-羟甲基-α-吡喃酮均为α-吡喃酮骨架类型的新化合物。

RESULTSPiperazin1yl 2(1pyridin2ylethoxy) acetamide has effects for ability of memory in mice.

结果］2［1（2吡啶）乙氧基］乙酰取代哌嗪具有促进小鼠记忆力的作用。

ABSTRACT:OBJECTIVETo synthesis the 4substitued piperazin1yl 2(1pyridin2ylethoxy) acetamide and study its effects for ability of memory in mice.

［目的］合成2［1（2吡啶）乙氧基］乙酰4取代哌嗪，探讨其对小鼠记忆力的影响。

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

Under the optimum condition, the maximum yield of more than 84% was obtained.

在最佳条件下，3-乙氧基-4-羟基苯乙醇酸的产率达84%以上。

On the optimum condition ,the maximum yield of 84.45% was obtained.

对3-乙氧基-4-羟基扁桃酸在铂电极上的电氧化进行了研究。

METHODSThe compounds were prepared by using 2ethylpyridine, through the Whol Ziegler reaction, the Williamson reaction and aminolysis. The effects for ability of memory in mice were measured by swimming maze test.

方法］以2乙基吡啶为原料，经WholZiegler反应、Williamson反应及氨解反应得到2［1（2吡啶）乙氧基］乙酰4取代哌嗪，采用水迷宫法观察所合成的化合物对小鼠记忆力的影响。

Aniline compounds are used as raw material and reacted with anthranilic acid and then phenyl iodide as alkylating agents to give alkylating products followed by cyclizing with concentrated sulphuric acid to give a N-phenyl-acridone(or 3-ethoxyl-N-phenylacridone).The structure of intermediate and target compound are determined by IR and MS.

以苯胺类化合物为原料，先后以邻氯苯甲酸和碘苯为烷基化试剂进行了N 烷基化反应，再用浓硫酸使其环化制得N-苯基吖啶酮和3-乙氧基-N-苯基吖啶酮，并用红外光谱及质谱仪检测了各中间体及目标产物的结构。

Article 144 The Government of the Hong Kong Special Administrative Region shall maintain the policy previously practised in Hong Kong in respect of subventions for non-governmental organizations in fields such as education, medicine and health, culture, art, recreation, sports, social welfare and social

第一百四十四条香港特别行政区政府保持原在香港实行的对教育、医疗卫生、文化、艺术、康乐、体育、社会福利、社会工作等方面的民间团体机构的资助政策。原在香港各资助机构任职的人员均可根据原有制度继续受聘。

Small wonder, then, that the Chinese spend more in the shop than any other group of foreign visitors do .

这样的小惊喜，使中国顾客比任何国家的人消费得更多。